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Onconeural antibodies are essential to diagnose paraneoplastic neurological syndromes.
Acta Neurol Scand Suppl 2006; 183:64-8AN

Abstract

Paraneoplastic neurological syndromes (PNS) can be defined as remote effects of cancer that are not caused by the tumor and its metastasis or by infection, ischemia or metabolic disruptions. In most patients, the neurological disorder develops before the cancer becomes clinically overt and the patient is referred to the neurologist who has the charge of identifying a neurological disorder as paraneoplastic. They are usually severely disabling. PNS are rare and are seen in less than 1% of patients with cancer. PNS depend on an autoimmune process triggered by cancer and directed to antigens common to both the cancer and the nervous system designated as onconeural antigens. Because of their high specificity (>90%), the best way to diagnose neurological disorders as paraneoplastic is to identify one of the well-characterized onconeural antibodies in the patient's serum. In addition, as these antibodies are associated with a restricted range of cancer, they permit orientating the search of the underlying tumor at a stage where it is frequently not clinically overt. This is a critical point, as today the best way to stabilize PNS is probably to treat the cancer as soon as possible. Unfortunately, about one-third of the patients do not have detectable antibodies and 5-10% have an atypical antibody that is not well characterized.

Authors+Show Affiliations

Hôpital Pierre Wertheimer, Hospices Civils de Lyon and INSERM U433 and Institut Fédératif des Neurosciences, Lyon, France. jerome.honnorat@chu-lyon.fr

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16637934

Citation

Honnorat, J. "Onconeural Antibodies Are Essential to Diagnose Paraneoplastic Neurological Syndromes." Acta Neurologica Scandinavica. Supplementum, vol. 183, 2006, pp. 64-8.
Honnorat J. Onconeural antibodies are essential to diagnose paraneoplastic neurological syndromes. Acta Neurol Scand, Suppl. 2006;183:64-8.
Honnorat, J. (2006). Onconeural antibodies are essential to diagnose paraneoplastic neurological syndromes. Acta Neurologica Scandinavica. Supplementum, 183, pp. 64-8.
Honnorat J. Onconeural Antibodies Are Essential to Diagnose Paraneoplastic Neurological Syndromes. Acta Neurol Scand, Suppl. 2006;183:64-8. PubMed PMID: 16637934.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Onconeural antibodies are essential to diagnose paraneoplastic neurological syndromes. A1 - Honnorat,J, PY - 2006/4/28/pubmed PY - 2006/6/29/medline PY - 2006/4/28/entrez SP - 64 EP - 8 JF - Acta neurologica Scandinavica. Supplementum JO - Acta Neurol. Scand., Suppl. VL - 183 N2 - Paraneoplastic neurological syndromes (PNS) can be defined as remote effects of cancer that are not caused by the tumor and its metastasis or by infection, ischemia or metabolic disruptions. In most patients, the neurological disorder develops before the cancer becomes clinically overt and the patient is referred to the neurologist who has the charge of identifying a neurological disorder as paraneoplastic. They are usually severely disabling. PNS are rare and are seen in less than 1% of patients with cancer. PNS depend on an autoimmune process triggered by cancer and directed to antigens common to both the cancer and the nervous system designated as onconeural antigens. Because of their high specificity (>90%), the best way to diagnose neurological disorders as paraneoplastic is to identify one of the well-characterized onconeural antibodies in the patient's serum. In addition, as these antibodies are associated with a restricted range of cancer, they permit orientating the search of the underlying tumor at a stage where it is frequently not clinically overt. This is a critical point, as today the best way to stabilize PNS is probably to treat the cancer as soon as possible. Unfortunately, about one-third of the patients do not have detectable antibodies and 5-10% have an atypical antibody that is not well characterized. SN - 0065-1427 UR - https://www.unboundmedicine.com/medline/citation/16637934/Onconeural_antibodies_are_essential_to_diagnose_paraneoplastic_neurological_syndromes_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0065-1427&date=2006&volume=183&issue=&spage=64 DB - PRIME DP - Unbound Medicine ER -