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[A multicentre study on the pathogenic agents in 665 adult patients with community-acquired pneumonia in cities of China].
Zhonghua Jie He He Hu Xi Za Zhi. 2006 Jan; 29(1):3-8.ZJ

Abstract

OBJECTIVE

To investigate the pathogenic causes of community-acquired pneumonia (CAP) in adult patients in China, the relation of previous antibiotic use and the Pneumonia Patient Outcome Research Team (PORT) classification to microbial etiology, and the prevalence of drug resistance of common CAP bacteria.

METHODS

A prospective study was performed on 665 consecutive adult patients with CAP at 12 centers in 7 Chinese cities during one year. The etiology of pneumonia was considered if one of the following criteria was met: (1) valid sputum sample yielding one or more predominant strains; (2) blood cultures yielding a bacterial pathogen; (3) seroconversion, a > or = 4-fold increase or decrease titers of antibodies to Mycoplasma pneumoniae, Chlamydia pneumoniae and Legionella pneumophila. Minimum inhibitory concentration (MIC) of respiratory tract isolates was determined using the agar dilution method.

RESULTS

Pathogens were identified in 324/610 patients (53.1%) with valid serum samples and sputum cultures as follows: Mycoplasma pneumoniae (126, 20.7%), Streptococcus pneumoniae (63, 10.3%), Haemophilus influenzae (56, 9.2%), Chlamydia pneumoniae (40, 6.6%), Klebsiella pneumoniae (37, 6.1%), Legionella pneumophila (31, 5.1%), Staphylococcus aureus (23, 3.8%), Escherichia coli (10, 1.6%), Moraxella catarrhalis (8, 1.3%), Pseudomonas aeruginosa (6, 1.0%). Of 195 patients with a bacterial pathogen, an atypical pathogen was identified in 62 (10.2%) cases. The non-susceptibility rate of Streptococcus pneumoniae to penicillin, azithromycin, and moxifloxacin was 20.3%, 75.4% and 4.3% respectively.

CONCLUSIONS

Atypical pathogens have important role in CAP, with Mycoplasma pneumoniae being the most common pathogen, and mixed infection of atypical pathogens with bacteria was found in 10.2% of the cases. Streptococcus pneumoniae and Haemophilus influenzae remain the most important bacteria for CAP. More than 75.0% of Streptococcus pneumoniae was resistant to macrolides and 20.3% was resistant to penicillin.

Authors+Show Affiliations

Department of Respiratory Medicine, General Hospital of PLA, Beijing 100853, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

chi

PubMed ID

16638292

Citation

Liu, You-ning, et al. "[A Multicentre Study On the Pathogenic Agents in 665 Adult Patients With Community-acquired Pneumonia in Cities of China]." Zhonghua Jie He He Hu Xi Za Zhi = Zhonghua Jiehe He Huxi Zazhi = Chinese Journal of Tuberculosis and Respiratory Diseases, vol. 29, no. 1, 2006, pp. 3-8.
Liu YN, Chen MJ, Zhao TM, et al. [A multicentre study on the pathogenic agents in 665 adult patients with community-acquired pneumonia in cities of China]. Zhonghua Jie He He Hu Xi Za Zhi. 2006;29(1):3-8.
Liu, Y. N., Chen, M. J., Zhao, T. M., Wang, H., Wang, R., Liu, Q. F., Cai, B. Q., Cao, B., Sun, T. Y., Hu, Y. J., Xiu, Q. Y., Zhou, X., Ding, X., Yang, L., Zhuo, J. S., Tang, Y. C., Zhang, K. X., Liang, D. R., Lü, X. J., ... Hou, X. N. (2006). [A multicentre study on the pathogenic agents in 665 adult patients with community-acquired pneumonia in cities of China]. Zhonghua Jie He He Hu Xi Za Zhi = Zhonghua Jiehe He Huxi Zazhi = Chinese Journal of Tuberculosis and Respiratory Diseases, 29(1), 3-8.
Liu YN, et al. [A Multicentre Study On the Pathogenic Agents in 665 Adult Patients With Community-acquired Pneumonia in Cities of China]. Zhonghua Jie He He Hu Xi Za Zhi. 2006;29(1):3-8. PubMed PMID: 16638292.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [A multicentre study on the pathogenic agents in 665 adult patients with community-acquired pneumonia in cities of China]. AU - Liu,You-ning, AU - Chen,Min-jun, AU - Zhao,Tie-mei, AU - Wang,Hui, AU - Wang,Rui, AU - Liu,Qing-feng, AU - Cai,Bai-qiang, AU - Cao,Bin, AU - Sun,Tie-ying, AU - Hu,Yun-jian, AU - Xiu,Qing-yu, AU - Zhou,Xin, AU - Ding,Xing, AU - Yang,Lan, AU - Zhuo,Jian-sheng, AU - Tang,Ying-chun, AU - Zhang,Kou-xing, AU - Liang,De-rong, AU - Lü,Xiao-ju, AU - Li,Sheng-qi, AU - Liu,Yong, AU - Yu,Yun-song, AU - Wei,Ze-qing, AU - Ying,Ke-jing, AU - Zhao,Feng, AU - Chen,Ping, AU - Hou,Xiao-na, PY - 2006/4/28/pubmed PY - 2010/9/8/medline PY - 2006/4/28/entrez SP - 3 EP - 8 JF - Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases JO - Zhonghua Jie He He Hu Xi Za Zhi VL - 29 IS - 1 N2 - OBJECTIVE: To investigate the pathogenic causes of community-acquired pneumonia (CAP) in adult patients in China, the relation of previous antibiotic use and the Pneumonia Patient Outcome Research Team (PORT) classification to microbial etiology, and the prevalence of drug resistance of common CAP bacteria. METHODS: A prospective study was performed on 665 consecutive adult patients with CAP at 12 centers in 7 Chinese cities during one year. The etiology of pneumonia was considered if one of the following criteria was met: (1) valid sputum sample yielding one or more predominant strains; (2) blood cultures yielding a bacterial pathogen; (3) seroconversion, a > or = 4-fold increase or decrease titers of antibodies to Mycoplasma pneumoniae, Chlamydia pneumoniae and Legionella pneumophila. Minimum inhibitory concentration (MIC) of respiratory tract isolates was determined using the agar dilution method. RESULTS: Pathogens were identified in 324/610 patients (53.1%) with valid serum samples and sputum cultures as follows: Mycoplasma pneumoniae (126, 20.7%), Streptococcus pneumoniae (63, 10.3%), Haemophilus influenzae (56, 9.2%), Chlamydia pneumoniae (40, 6.6%), Klebsiella pneumoniae (37, 6.1%), Legionella pneumophila (31, 5.1%), Staphylococcus aureus (23, 3.8%), Escherichia coli (10, 1.6%), Moraxella catarrhalis (8, 1.3%), Pseudomonas aeruginosa (6, 1.0%). Of 195 patients with a bacterial pathogen, an atypical pathogen was identified in 62 (10.2%) cases. The non-susceptibility rate of Streptococcus pneumoniae to penicillin, azithromycin, and moxifloxacin was 20.3%, 75.4% and 4.3% respectively. CONCLUSIONS: Atypical pathogens have important role in CAP, with Mycoplasma pneumoniae being the most common pathogen, and mixed infection of atypical pathogens with bacteria was found in 10.2% of the cases. Streptococcus pneumoniae and Haemophilus influenzae remain the most important bacteria for CAP. More than 75.0% of Streptococcus pneumoniae was resistant to macrolides and 20.3% was resistant to penicillin. SN - 1001-0939 UR - https://www.unboundmedicine.com/medline/citation/16638292/[A_multicentre_study_on_the_pathogenic_agents_in_665_adult_patients_with_community_acquired_pneumonia_in_cities_of_China]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&issn=1001-0939&year=2006&vol=29&issue=1&fpage=3 DB - PRIME DP - Unbound Medicine ER -