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Plasma levels of beta-amyloid (1-42) in Alzheimer's disease and mild cognitive impairment.
Neurobiol Aging. 2006 Jun; 27(6):904-5.NA

Abstract

We compared plasma levels of beta-amyloid 1-42 (pg/ml) found for 146 sporadic Alzheimer (AD) patients, 89 subjects with mild cognitive impairment (MCI) and 89 age-matched controls (CT). AD patients had significantly lower levels (38, 54, 52; p<0.01), unrelated to severity of the disease as assessed by MMSE score, age, sex or APOE4 status. Twenty cases investigated at two time points 18 months apart did not demonstrate further decreases. Thus, the reduction in beta-amyloid 1-42 may be a marker for AD status, specifically, a transition from normal status or MCI to AD, rather than a marker for neurodegenerative processes occurring in the disease.

Authors+Show Affiliations

Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, 20157 Milan, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16638622

Citation

Pesaresi, Marzia, et al. "Plasma Levels of Beta-amyloid (1-42) in Alzheimer's Disease and Mild Cognitive Impairment." Neurobiology of Aging, vol. 27, no. 6, 2006, pp. 904-5.
Pesaresi M, Lovati C, Bertora P, et al. Plasma levels of beta-amyloid (1-42) in Alzheimer's disease and mild cognitive impairment. Neurobiol Aging. 2006;27(6):904-5.
Pesaresi, M., Lovati, C., Bertora, P., Mailland, E., Galimberti, D., Scarpini, E., Quadri, P., Forloni, G., & Mariani, C. (2006). Plasma levels of beta-amyloid (1-42) in Alzheimer's disease and mild cognitive impairment. Neurobiology of Aging, 27(6), 904-5.
Pesaresi M, et al. Plasma Levels of Beta-amyloid (1-42) in Alzheimer's Disease and Mild Cognitive Impairment. Neurobiol Aging. 2006;27(6):904-5. PubMed PMID: 16638622.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma levels of beta-amyloid (1-42) in Alzheimer's disease and mild cognitive impairment. AU - Pesaresi,Marzia, AU - Lovati,Carlo, AU - Bertora,Pierluigi, AU - Mailland,Enrico, AU - Galimberti,Daniela, AU - Scarpini,Elio, AU - Quadri,Pierluigi, AU - Forloni,Gianluigi, AU - Mariani,Claudio, Y1 - 2006/04/25/ PY - 2005/09/26/received PY - 2006/01/30/revised PY - 2006/03/07/accepted PY - 2006/4/28/pubmed PY - 2006/7/27/medline PY - 2006/4/28/entrez SP - 904 EP - 5 JF - Neurobiology of aging JO - Neurobiol. Aging VL - 27 IS - 6 N2 - We compared plasma levels of beta-amyloid 1-42 (pg/ml) found for 146 sporadic Alzheimer (AD) patients, 89 subjects with mild cognitive impairment (MCI) and 89 age-matched controls (CT). AD patients had significantly lower levels (38, 54, 52; p<0.01), unrelated to severity of the disease as assessed by MMSE score, age, sex or APOE4 status. Twenty cases investigated at two time points 18 months apart did not demonstrate further decreases. Thus, the reduction in beta-amyloid 1-42 may be a marker for AD status, specifically, a transition from normal status or MCI to AD, rather than a marker for neurodegenerative processes occurring in the disease. SN - 0197-4580 UR - https://www.unboundmedicine.com/medline/citation/16638622/Plasma_levels_of_beta_amyloid__1_42__in_Alzheimer's_disease_and_mild_cognitive_impairment_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0197-4580(06)00089-3 DB - PRIME DP - Unbound Medicine ER -