Tags

Type your tag names separated by a space and hit enter

Ultrastructural study of the filum terminale and its elastic fibers.
Neurosurgery. 2006 May; 58(5):978-84; discussion 978-84.N

Abstract

OBJECTIVE

The filum terminale (FT) is a fibrovascular band involved in the pathophysiology of tethered cord syndrome (TCS). Its morphological and ultrastructural properties remain largely unknown even though they are thought to play a role in the generation of TCS in adult patients with normal level conus medullaris.

MATERIALS AND METHODS

Twenty fresh adult human cadavers had their fila measured and removed. Transversal and longitudinal sections of the proximal, middle, and distal thirds of FT were submitted to light microscopy analysis with four different techniques. Five fila were selected for longitudinal and transversal scanning electron microscopy analysis.

RESULTS

The bulk of the FT is composed of 5- to 20-microm thick longitudinal bundles of Type 1 collagen separated by 3- to 10-microm intervals, although capillaries and other elements may be present. A delicate (0.05-1.5 microm) meshwork of predominantly Type 3 collagen transversal fibers connects these bundles. Abundant longitudinally oriented elastic and elaunin fibers are found inside collagen bundles. A complex tridimensional structure is evidenced on electron microscopy.

CONCLUSION

The longitudinal arrangement of collagen bundles and the impressive amount of elastic and elaunin fibers should elicit considerable elastic properties to the FT. An altered elasticity mechanism has been proposed for TCS; further studies are needed with TCS patients to define whether the collagen structure, Type 1/Type 3 proportion, or elastic fiber content are altered, which could lead to new histopathological definitions of TCS, helping neurosurgeons in the difficult management of TCS patients with normal level conus medullaris.

Authors+Show Affiliations

VQM Laboratory, Department of Anatomy, Instituto de Ciencias Biomedicas, and Liga de Neurocirurgia, Faculdade de Medicina, da Universidade de São Paulo, São Paulo, Brazil. rbvfontes@yahoo.com.brNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16639335

Citation

Fontes, Ricardo B V., et al. "Ultrastructural Study of the Filum Terminale and Its Elastic Fibers." Neurosurgery, vol. 58, no. 5, 2006, pp. 978-84; discussion 978-84.
Fontes RB, Saad F, Soares MS, et al. Ultrastructural study of the filum terminale and its elastic fibers. Neurosurgery. 2006;58(5):978-84; discussion 978-84.
Fontes, R. B., Saad, F., Soares, M. S., de Oliveira, F., Pinto, F. C., & Liberti, E. A. (2006). Ultrastructural study of the filum terminale and its elastic fibers. Neurosurgery, 58(5), 978-84; discussion 978-84.
Fontes RB, et al. Ultrastructural Study of the Filum Terminale and Its Elastic Fibers. Neurosurgery. 2006;58(5):978-84; discussion 978-84. PubMed PMID: 16639335.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ultrastructural study of the filum terminale and its elastic fibers. AU - Fontes,Ricardo B V, AU - Saad,Felippe, AU - Soares,Matheus S, AU - de Oliveira,Flavia, AU - Pinto,Fernando C G, AU - Liberti,Edson A, PY - 2006/4/28/pubmed PY - 2006/8/17/medline PY - 2006/4/28/entrez SP - 978-84; discussion 978-84 JF - Neurosurgery JO - Neurosurgery VL - 58 IS - 5 N2 - OBJECTIVE: The filum terminale (FT) is a fibrovascular band involved in the pathophysiology of tethered cord syndrome (TCS). Its morphological and ultrastructural properties remain largely unknown even though they are thought to play a role in the generation of TCS in adult patients with normal level conus medullaris. MATERIALS AND METHODS: Twenty fresh adult human cadavers had their fila measured and removed. Transversal and longitudinal sections of the proximal, middle, and distal thirds of FT were submitted to light microscopy analysis with four different techniques. Five fila were selected for longitudinal and transversal scanning electron microscopy analysis. RESULTS: The bulk of the FT is composed of 5- to 20-microm thick longitudinal bundles of Type 1 collagen separated by 3- to 10-microm intervals, although capillaries and other elements may be present. A delicate (0.05-1.5 microm) meshwork of predominantly Type 3 collagen transversal fibers connects these bundles. Abundant longitudinally oriented elastic and elaunin fibers are found inside collagen bundles. A complex tridimensional structure is evidenced on electron microscopy. CONCLUSION: The longitudinal arrangement of collagen bundles and the impressive amount of elastic and elaunin fibers should elicit considerable elastic properties to the FT. An altered elasticity mechanism has been proposed for TCS; further studies are needed with TCS patients to define whether the collagen structure, Type 1/Type 3 proportion, or elastic fiber content are altered, which could lead to new histopathological definitions of TCS, helping neurosurgeons in the difficult management of TCS patients with normal level conus medullaris. SN - 1524-4040 UR - https://www.unboundmedicine.com/medline/citation/16639335/Ultrastructural_study_of_the_filum_terminale_and_its_elastic_fibers_ L2 - https://academic.oup.com/neurosurgery/article-lookup/doi/10.1227/01.NEU.0000210224.54816.40 DB - PRIME DP - Unbound Medicine ER -