Tags

Type your tag names separated by a space and hit enter

Serum homocysteine, folate level and methylenetetrahydrofolate reductase 677, 1298 gene polymorphism in Korean schizophrenic patients.
Neuroreport 2006; 17(7):743-6N

Abstract

High homocysteine serum level has been regarded as one of the important factors that influence the development of schizophrenia. Genetic variations of methylenetetrahydrofolate reductase, which is a main enzyme reducing homocysteine level, are reported in schizophrenic patients. We measured the serum level of homocysteine/folate and methylenetetrahydrofolate reductase C677T/A1298C gene polymorphism in 235 patients with schizophrenia. Plasma homocysteine levels were higher and folate levels were lower in patients than in comparison subjects. Variations of C677T were more frequent in patients than in comparison subjects. Patients with the 677TT genotype showed higher homocysteine levels than patients with the CC and CT genotypes. These findings suggest that folate supplement may be beneficial to some schizophrenic patients with homocysteinemia due to the genetic defect of methylenetetrahydrofolate reductase.

Authors+Show Affiliations

Department of Neuropsychiatry, College of Medicine, Chung-Ang University Medical Center, Seoul National University Hospital, Korea.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16641680

Citation

Lee, Young Sik, et al. "Serum Homocysteine, Folate Level and Methylenetetrahydrofolate Reductase 677, 1298 Gene Polymorphism in Korean Schizophrenic Patients." Neuroreport, vol. 17, no. 7, 2006, pp. 743-6.
Lee YS, Han DH, Jeon CM, et al. Serum homocysteine, folate level and methylenetetrahydrofolate reductase 677, 1298 gene polymorphism in Korean schizophrenic patients. Neuroreport. 2006;17(7):743-6.
Lee, Y. S., Han, D. H., Jeon, C. M., Lyoo, I. K., Na, C., Chae, S. L., & Cho, S. C. (2006). Serum homocysteine, folate level and methylenetetrahydrofolate reductase 677, 1298 gene polymorphism in Korean schizophrenic patients. Neuroreport, 17(7), pp. 743-6.
Lee YS, et al. Serum Homocysteine, Folate Level and Methylenetetrahydrofolate Reductase 677, 1298 Gene Polymorphism in Korean Schizophrenic Patients. Neuroreport. 2006 May 15;17(7):743-6. PubMed PMID: 16641680.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum homocysteine, folate level and methylenetetrahydrofolate reductase 677, 1298 gene polymorphism in Korean schizophrenic patients. AU - Lee,Young Sik, AU - Han,Doug Hyun, AU - Jeon,Chang Moo, AU - Lyoo,In Kyoon, AU - Na,Chul, AU - Chae,Seok Lae, AU - Cho,Soo Churl, PY - 2006/4/28/pubmed PY - 2006/7/27/medline PY - 2006/4/28/entrez SP - 743 EP - 6 JF - Neuroreport JO - Neuroreport VL - 17 IS - 7 N2 - High homocysteine serum level has been regarded as one of the important factors that influence the development of schizophrenia. Genetic variations of methylenetetrahydrofolate reductase, which is a main enzyme reducing homocysteine level, are reported in schizophrenic patients. We measured the serum level of homocysteine/folate and methylenetetrahydrofolate reductase C677T/A1298C gene polymorphism in 235 patients with schizophrenia. Plasma homocysteine levels were higher and folate levels were lower in patients than in comparison subjects. Variations of C677T were more frequent in patients than in comparison subjects. Patients with the 677TT genotype showed higher homocysteine levels than patients with the CC and CT genotypes. These findings suggest that folate supplement may be beneficial to some schizophrenic patients with homocysteinemia due to the genetic defect of methylenetetrahydrofolate reductase. SN - 0959-4965 UR - https://www.unboundmedicine.com/medline/citation/16641680/Serum_homocysteine_folate_level_and_methylenetetrahydrofolate_reductase_677_1298_gene_polymorphism_in_Korean_schizophrenic_patients_ L2 - http://Insights.ovid.com/pubmed?pmid=16641680 DB - PRIME DP - Unbound Medicine ER -