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[Variant genotyping of CCR2-64I, SDF1-3' A and CCR5Delta32 in HIV-1 infected Chinese long-term nonprogressors].

Abstract

BACKGROUND

To investigate variant genotyping of CCR2-64I, SDF1-3'A and CCR5Delta32 in HIV-1 infected Chinese Long-term nonprogressors and to study their association with disease progression.

METHODS

The genotypes of CCR2-64I, SDF1-3'A and CCR5Delta32 were detected by polymerase chain reaction/restriction fragment length polymorphism (PCR/RFLP) assay in seventeen HIV-1 infected Chinese Long-term nonprogressors (LTNPs) and thirty-nine Chinese typical progressors (TPs).

RESULTS

The frequency of CCR2-64I and SDF1-3'A in LTNPs are 50% and 62.5%, higher than those (23.08% and 33.33%) in TPs. Only one heterozygous CCR5 mutant was detected in LTNPs, and no CCR5 mutant in TPs.

CONCLUSION

Variant genotyping of CCR2-64ISDF1-3'A and CCR5Delta32 may be protective factors for delaying disease progression in HIV-1 infected Chinese LTNPs.

Authors+Show Affiliations

AIDS Research Center, The First Affiliated Hospital of China Medical University, Shenyang 110001, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

16642210

Citation

Wang, Shu-xiang, et al. "[Variant Genotyping of CCR2-64I, SDF1-3' a and CCR5Delta32 in HIV-1 Infected Chinese Long-term Nonprogressors]." Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi = Zhonghua Shiyan He Linchuang Bingduxue Zazhi = Chinese Journal of Experimental and Clinical Virology, vol. 20, no. 1, 2006, pp. 16-9.
Wang SX, Shang H, Han XX, et al. [Variant genotyping of CCR2-64I, SDF1-3' A and CCR5Delta32 in HIV-1 infected Chinese long-term nonprogressors]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2006;20(1):16-9.
Wang, S. X., Shang, H., Han, X. X., Zhang, Z. N., Wang, Y. N., Zhang, M., Jiang, Y. J., Liu, J., & Su, Y. L. (2006). [Variant genotyping of CCR2-64I, SDF1-3' A and CCR5Delta32 in HIV-1 infected Chinese long-term nonprogressors]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi = Zhonghua Shiyan He Linchuang Bingduxue Zazhi = Chinese Journal of Experimental and Clinical Virology, 20(1), 16-9.
Wang SX, et al. [Variant Genotyping of CCR2-64I, SDF1-3' a and CCR5Delta32 in HIV-1 Infected Chinese Long-term Nonprogressors]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2006;20(1):16-9. PubMed PMID: 16642210.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Variant genotyping of CCR2-64I, SDF1-3' A and CCR5Delta32 in HIV-1 infected Chinese long-term nonprogressors]. AU - Wang,Shu-xiang, AU - Shang,Hong, AU - Han,Xiao-xu, AU - Zhang,Zi-ning, AU - Wang,Ya-nan, AU - Zhang,Min, AU - Jiang,Yong-jun, AU - Liu,Jing, AU - Su,Yan-li, PY - 2006/4/28/pubmed PY - 2008/12/23/medline PY - 2006/4/28/entrez SP - 16 EP - 9 JF - Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology JO - Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi VL - 20 IS - 1 N2 - BACKGROUND: To investigate variant genotyping of CCR2-64I, SDF1-3'A and CCR5Delta32 in HIV-1 infected Chinese Long-term nonprogressors and to study their association with disease progression. METHODS: The genotypes of CCR2-64I, SDF1-3'A and CCR5Delta32 were detected by polymerase chain reaction/restriction fragment length polymorphism (PCR/RFLP) assay in seventeen HIV-1 infected Chinese Long-term nonprogressors (LTNPs) and thirty-nine Chinese typical progressors (TPs). RESULTS: The frequency of CCR2-64I and SDF1-3'A in LTNPs are 50% and 62.5%, higher than those (23.08% and 33.33%) in TPs. Only one heterozygous CCR5 mutant was detected in LTNPs, and no CCR5 mutant in TPs. CONCLUSION: Variant genotyping of CCR2-64ISDF1-3'A and CCR5Delta32 may be protective factors for delaying disease progression in HIV-1 infected Chinese LTNPs. SN - 1003-9279 UR - https://www.unboundmedicine.com/medline/citation/16642210/[Variant_genotyping_of_CCR2_64I_SDF1_3'_A_and_CCR5Delta32_in_HIV_1_infected_Chinese_long_term_nonprogressors]_ L2 - http://www.diseaseinfosearch.org/result/9735 DB - PRIME DP - Unbound Medicine ER -