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[Effects of Shuanggu Yitong needling method on proliferation and differentiation of nerve stem cells in the Parkinson's disease model rat].

Abstract

OBJECTIVE

To explore the mechanism of acupuncture in treatment of Parkinson's disease.

METHODS

Fifty Wistar rats were randomly divided into a normal control group, a sham-operation control group, a model group, a Fengfu-Taichong group and a Shuanggu Yitong group. The hemilateral rotation Parkinson's disease model was prepared by micro-injection of 6-hydroxyl-dopamine into the right striatum. Effects of acupuncture at "Fengfu" (GV 16), "Taichong" (LR 3) hy Shoanggu Yitong needling method on proliferation and differentiation of nerve stem cells in the Parkinson's disease model rat were compared. Proliferation and numher changes of the nerve stem cells in the suhstantia nigra and the striatum were investigated with immunohistochemical method, and the number of nerve stem cells transforming neurons were observed with immunohistochemical double-labeling method.

RESULTS

In the two acupuncture groups, the proliferative cells in the substantia nigra and thestriatum of the destroyed side increased significantly (P < 0.01), and the number of nerve stem cells and the number of transformed neurons in the destroyed side of the substantia nigra and the striatum increased significantly only in the Shuanggu Yitong group (P < 0.01).

CONCLUSION

Shuanggu Yitong needling method can induce proliferation and differentiation of nerve stem cells in the substantia nigra and the striatum regions in the Parkinson's disease model rat.

Authors+Show Affiliations

,

Department of Acup-Moxibustion, Orthopedics and Traumatology, Wuhan 430061, China. wangyanchunonly@yahoo.com.cn

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Source

MeSH

Acupuncture Therapy
Animals
Bromodeoxyuridine
Cell Differentiation
Cell Proliferation
Corpus Striatum
Male
Neurons
Parkinson Disease
Rats
Rats, Wistar
Stem Cells
Substantia Nigra

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

16642616

Citation

Wang, Yan-chun, et al. "[Effects of Shuanggu Yitong Needling Method On Proliferation and Differentiation of Nerve Stem Cells in the Parkinson's Disease Model Rat]." Zhongguo Zhen Jiu = Chinese Acupuncture & Moxibustion, vol. 26, no. 4, 2006, pp. 277-82.
Wang YC, Ma J, Wang H. [Effects of Shuanggu Yitong needling method on proliferation and differentiation of nerve stem cells in the Parkinson's disease model rat]. Zhongguo Zhen Jiu. 2006;26(4):277-82.
Wang, Y. C., Ma, J., & Wang, H. (2006). [Effects of Shuanggu Yitong needling method on proliferation and differentiation of nerve stem cells in the Parkinson's disease model rat]. Zhongguo Zhen Jiu = Chinese Acupuncture & Moxibustion, 26(4), pp. 277-82.
Wang YC, Ma J, Wang H. [Effects of Shuanggu Yitong Needling Method On Proliferation and Differentiation of Nerve Stem Cells in the Parkinson's Disease Model Rat]. Zhongguo Zhen Jiu. 2006;26(4):277-82. PubMed PMID: 16642616.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effects of Shuanggu Yitong needling method on proliferation and differentiation of nerve stem cells in the Parkinson's disease model rat]. AU - Wang,Yan-chun, AU - Ma,Jun, AU - Wang,Hua, PY - 2006/4/29/pubmed PY - 2006/5/23/medline PY - 2006/4/29/entrez SP - 277 EP - 82 JF - Zhongguo zhen jiu = Chinese acupuncture & moxibustion JO - Zhongguo Zhen Jiu VL - 26 IS - 4 N2 - OBJECTIVE: To explore the mechanism of acupuncture in treatment of Parkinson's disease. METHODS: Fifty Wistar rats were randomly divided into a normal control group, a sham-operation control group, a model group, a Fengfu-Taichong group and a Shuanggu Yitong group. The hemilateral rotation Parkinson's disease model was prepared by micro-injection of 6-hydroxyl-dopamine into the right striatum. Effects of acupuncture at "Fengfu" (GV 16), "Taichong" (LR 3) hy Shoanggu Yitong needling method on proliferation and differentiation of nerve stem cells in the Parkinson's disease model rat were compared. Proliferation and numher changes of the nerve stem cells in the suhstantia nigra and the striatum were investigated with immunohistochemical method, and the number of nerve stem cells transforming neurons were observed with immunohistochemical double-labeling method. RESULTS: In the two acupuncture groups, the proliferative cells in the substantia nigra and thestriatum of the destroyed side increased significantly (P < 0.01), and the number of nerve stem cells and the number of transformed neurons in the destroyed side of the substantia nigra and the striatum increased significantly only in the Shuanggu Yitong group (P < 0.01). CONCLUSION: Shuanggu Yitong needling method can induce proliferation and differentiation of nerve stem cells in the substantia nigra and the striatum regions in the Parkinson's disease model rat. SN - 0255-2930 UR - https://www.unboundmedicine.com/medline/citation/16642616/[Effects_of_Shuanggu_Yitong_needling_method_on_proliferation_and_differentiation_of_nerve_stem_cells_in_the_Parkinson's_disease_model_rat]_ L2 - https://medlineplus.gov/parkinsonsdisease.html DB - PRIME DP - Unbound Medicine ER -