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Molecular changes in the gingival epithelium associated with necrotizing ulcerative periodontitis: a case report.
Int J Periodontics Restorative Dent. 2006 Apr; 26(2):191-6.IJ

Abstract

A case of necrotizing ulcerative periodontitis (NUP), the most severe inflammatory periodontal disorder caused by plaque bacteria, is shown. Clinically, the gingiva showed distinct signs of ulceration, and radiography revealed horizontal bone loss. Indirect immunofluorescence, carried out on frozen sections of tissue specimens obtained from the NUP lesion, exhibited clear expression of atypical keratin K19, particularly in basal cells, when compared to noninflamed gingiva. Moreover, NUP tissue showed extensive intraepithelial abundance for the basement membrane component laminin-1/10 and the extracellular matrix molecule tenascin. Strong expression of integrin subunit alphav and matrix metalloproteinase-13 in conjunction with interleukin 1-beta further discriminated NUP gingival epithelium from normal tissue. The results suggest that NUP is associated with changes in the expression and topography of the analyzed molecules in the gingival epithelium, which in turn may reflect the fast progression of the disease.

Authors+Show Affiliations

Section of Periodontology, Department of Operative Dentistry and Periodontology, Dental School, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany. Bettina.Dannewitz@med.uni-heidelberg.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16642908

Citation

Dannewitz, Bettina, et al. "Molecular Changes in the Gingival Epithelium Associated With Necrotizing Ulcerative Periodontitis: a Case Report." The International Journal of Periodontics & Restorative Dentistry, vol. 26, no. 2, 2006, pp. 191-6.
Dannewitz B, Eickholz P, Kohl A, et al. Molecular changes in the gingival epithelium associated with necrotizing ulcerative periodontitis: a case report. Int J Periodontics Restorative Dent. 2006;26(2):191-6.
Dannewitz, B., Eickholz, P., Kohl, A., Komposch, G., & Tomakidi, P. (2006). Molecular changes in the gingival epithelium associated with necrotizing ulcerative periodontitis: a case report. The International Journal of Periodontics & Restorative Dentistry, 26(2), 191-6.
Dannewitz B, et al. Molecular Changes in the Gingival Epithelium Associated With Necrotizing Ulcerative Periodontitis: a Case Report. Int J Periodontics Restorative Dent. 2006;26(2):191-6. PubMed PMID: 16642908.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Molecular changes in the gingival epithelium associated with necrotizing ulcerative periodontitis: a case report. AU - Dannewitz,Bettina, AU - Eickholz,Peter, AU - Kohl,Annette, AU - Komposch,Gerda, AU - Tomakidi,Pascal, PY - 2006/4/29/pubmed PY - 2006/6/7/medline PY - 2006/4/29/entrez SP - 191 EP - 6 JF - The International journal of periodontics & restorative dentistry JO - Int J Periodontics Restorative Dent VL - 26 IS - 2 N2 - A case of necrotizing ulcerative periodontitis (NUP), the most severe inflammatory periodontal disorder caused by plaque bacteria, is shown. Clinically, the gingiva showed distinct signs of ulceration, and radiography revealed horizontal bone loss. Indirect immunofluorescence, carried out on frozen sections of tissue specimens obtained from the NUP lesion, exhibited clear expression of atypical keratin K19, particularly in basal cells, when compared to noninflamed gingiva. Moreover, NUP tissue showed extensive intraepithelial abundance for the basement membrane component laminin-1/10 and the extracellular matrix molecule tenascin. Strong expression of integrin subunit alphav and matrix metalloproteinase-13 in conjunction with interleukin 1-beta further discriminated NUP gingival epithelium from normal tissue. The results suggest that NUP is associated with changes in the expression and topography of the analyzed molecules in the gingival epithelium, which in turn may reflect the fast progression of the disease. SN - 0198-7569 UR - https://www.unboundmedicine.com/medline/citation/16642908/Molecular_changes_in_the_gingival_epithelium_associated_with_necrotizing_ulcerative_periodontitis:_a_case_report_ DB - PRIME DP - Unbound Medicine ER -