Tags

Type your tag names separated by a space and hit enter

Metabolic actions of adipocyte hormones: focus on adiponectin.

Abstract

The obesity epidemic has focused attention on the endocrine function of adipose tissue. Adipose tissue secretes leptin, cytokines, complement factors, and components of the coagulation cascade, most of which are increased in obesity. In contrast, a strong negative correlation exists between adiponectin and adiposity, insulin sensitivity, diabetes, vascular inflammation, and atherosclerosis. Adiponectin treatment in rodents increases insulin sensitivity and reduces lipids and atherogenesis. Chronic and central adiponectin treatment reduces weight, glucose, and lipids. The insulin-sensitizing action of thiazolidinediones is mediated, in part, through adiponectin. A causal role of adiponectin in diabetes, dyslipidemia, and atherosclerosis has been established in knockout mice. Therefore, adiponectin seems to be a marker of obesity-related diseases and a potential therapeutic target.

Links

  • FREE Publisher Full Text
  • Authors+Show Affiliations

    Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. ahima@mail.med.upenn.edu

    Source

    Obesity (Silver Spring, Md.) 14 Suppl 1: 2006 Feb pg 9S-15S

    MeSH

    Adipocytes
    Adiponectin
    Animals
    Disease Models, Animal
    Energy Metabolism
    Homeostasis
    Humans
    Leptin
    Mice
    Mice, Knockout
    Obesity

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Review

    Language

    eng

    PubMed ID

    16642957

    Citation

    Ahima, Rexford S.. "Metabolic Actions of Adipocyte Hormones: Focus On Adiponectin." Obesity (Silver Spring, Md.), vol. 14 Suppl 1, 2006, 9S-15S.
    Ahima RS. Metabolic actions of adipocyte hormones: focus on adiponectin. Obesity (Silver Spring). 2006;14 Suppl 1:9S-15S.
    Ahima, R. S. (2006). Metabolic actions of adipocyte hormones: focus on adiponectin. Obesity (Silver Spring, Md.), 14 Suppl 1, 9S-15S.
    Ahima RS. Metabolic Actions of Adipocyte Hormones: Focus On Adiponectin. Obesity (Silver Spring). 2006;14 Suppl 1:9S-15S. PubMed PMID: 16642957.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Metabolic actions of adipocyte hormones: focus on adiponectin. A1 - Ahima,Rexford S, PY - 2006/4/29/pubmed PY - 2006/9/6/medline PY - 2006/4/29/entrez SP - 9S EP - 15S JF - Obesity (Silver Spring, Md.) JO - Obesity (Silver Spring) VL - 14 Suppl 1 N2 - The obesity epidemic has focused attention on the endocrine function of adipose tissue. Adipose tissue secretes leptin, cytokines, complement factors, and components of the coagulation cascade, most of which are increased in obesity. In contrast, a strong negative correlation exists between adiponectin and adiposity, insulin sensitivity, diabetes, vascular inflammation, and atherosclerosis. Adiponectin treatment in rodents increases insulin sensitivity and reduces lipids and atherogenesis. Chronic and central adiponectin treatment reduces weight, glucose, and lipids. The insulin-sensitizing action of thiazolidinediones is mediated, in part, through adiponectin. A causal role of adiponectin in diabetes, dyslipidemia, and atherosclerosis has been established in knockout mice. Therefore, adiponectin seems to be a marker of obesity-related diseases and a potential therapeutic target. SN - 1930-7381 UR - https://www.unboundmedicine.com/medline/citation/16642957/Metabolic_actions_of_adipocyte_hormones:_focus_on_adiponectin_ L2 - https://doi.org/10.1038/oby.2006.276 DB - PRIME DP - Unbound Medicine ER -