Tags

Type your tag names separated by a space and hit enter

Metabolic actions of adipocyte hormones: focus on adiponectin.
Obesity (Silver Spring) 2006; 14 Suppl 1:9S-15SO

Abstract

The obesity epidemic has focused attention on the endocrine function of adipose tissue. Adipose tissue secretes leptin, cytokines, complement factors, and components of the coagulation cascade, most of which are increased in obesity. In contrast, a strong negative correlation exists between adiponectin and adiposity, insulin sensitivity, diabetes, vascular inflammation, and atherosclerosis. Adiponectin treatment in rodents increases insulin sensitivity and reduces lipids and atherogenesis. Chronic and central adiponectin treatment reduces weight, glucose, and lipids. The insulin-sensitizing action of thiazolidinediones is mediated, in part, through adiponectin. A causal role of adiponectin in diabetes, dyslipidemia, and atherosclerosis has been established in knockout mice. Therefore, adiponectin seems to be a marker of obesity-related diseases and a potential therapeutic target.

Authors+Show Affiliations

Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. ahima@mail.med.upenn.edu

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

16642957

Citation

Ahima, Rexford S.. "Metabolic Actions of Adipocyte Hormones: Focus On Adiponectin." Obesity (Silver Spring, Md.), vol. 14 Suppl 1, 2006, 9S-15S.
Ahima RS. Metabolic actions of adipocyte hormones: focus on adiponectin. Obesity (Silver Spring). 2006;14 Suppl 1:9S-15S.
Ahima, R. S. (2006). Metabolic actions of adipocyte hormones: focus on adiponectin. Obesity (Silver Spring, Md.), 14 Suppl 1, 9S-15S.
Ahima RS. Metabolic Actions of Adipocyte Hormones: Focus On Adiponectin. Obesity (Silver Spring). 2006;14 Suppl 1:9S-15S. PubMed PMID: 16642957.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metabolic actions of adipocyte hormones: focus on adiponectin. A1 - Ahima,Rexford S, PY - 2006/4/29/pubmed PY - 2006/9/6/medline PY - 2006/4/29/entrez SP - 9S EP - 15S JF - Obesity (Silver Spring, Md.) JO - Obesity (Silver Spring) VL - 14 Suppl 1 N2 - The obesity epidemic has focused attention on the endocrine function of adipose tissue. Adipose tissue secretes leptin, cytokines, complement factors, and components of the coagulation cascade, most of which are increased in obesity. In contrast, a strong negative correlation exists between adiponectin and adiposity, insulin sensitivity, diabetes, vascular inflammation, and atherosclerosis. Adiponectin treatment in rodents increases insulin sensitivity and reduces lipids and atherogenesis. Chronic and central adiponectin treatment reduces weight, glucose, and lipids. The insulin-sensitizing action of thiazolidinediones is mediated, in part, through adiponectin. A causal role of adiponectin in diabetes, dyslipidemia, and atherosclerosis has been established in knockout mice. Therefore, adiponectin seems to be a marker of obesity-related diseases and a potential therapeutic target. SN - 1930-7381 UR - https://www.unboundmedicine.com/medline/citation/16642957/Metabolic_actions_of_adipocyte_hormones:_focus_on_adiponectin_ L2 - https://doi.org/10.1038/oby.2006.276 DB - PRIME DP - Unbound Medicine ER -