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Sesquiterpene lactones from Inula britannica and their cytotoxic and apoptotic effects on human cancer cell lines.
J Nat Prod. 2006 Apr; 69(4):531-5.JN

Abstract

Three new sesquiterpenes (1-3), together with four known sesquiterpene lactones, were isolated from the flowers of Inula britannica var. chinensis. Structures were established on the basis of high-field 1D and 2D NMR methods supported by HRMS. All sesquiterpene lactones were tested for cytotoxicity as well as apoptotic ratio in human COLO 205, HT 29, HL-60, and AGS cancer cells. Compounds 3 and 4, two alpha-methylene gamma-lactone-bearing sesquiterpenes, were modestly active in these assays.

Authors+Show Affiliations

Bai N
Department of Food Science, Rutgers University, 65 Dudley Road, New Brunswick, NJ 08901, USA.
Lai CS
No affiliation info available
He K
No affiliation info available
Zhou Z
No affiliation info available
Zhang L
No affiliation info available
Quan Z
No affiliation info available
Zhu N
No affiliation info available
Zheng QY
No affiliation info available
Pan MH
No affiliation info available
Ho CT
No affiliation info available

MeSH

Antineoplastic Agents, PhytogenicCell Line, TumorDrug Screening Assays, AntitumorDrugs, Chinese HerbalFlowersHumansInulaLactonesMolecular StructurePlants, MedicinalSesquiterpenes

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16643020

Citation

Bai, Naisheng, et al. "Sesquiterpene Lactones From Inula Britannica and Their Cytotoxic and Apoptotic Effects On Human Cancer Cell Lines." Journal of Natural Products, vol. 69, no. 4, 2006, pp. 531-5.
Bai N, Lai CS, He K, et al. Sesquiterpene lactones from Inula britannica and their cytotoxic and apoptotic effects on human cancer cell lines. J Nat Prod. 2006;69(4):531-5.
Bai, N., Lai, C. S., He, K., Zhou, Z., Zhang, L., Quan, Z., Zhu, N., Zheng, Q. Y., Pan, M. H., & Ho, C. T. (2006). Sesquiterpene lactones from Inula britannica and their cytotoxic and apoptotic effects on human cancer cell lines. Journal of Natural Products, 69(4), 531-5.
Bai N, et al. Sesquiterpene Lactones From Inula Britannica and Their Cytotoxic and Apoptotic Effects On Human Cancer Cell Lines. J Nat Prod. 2006;69(4):531-5. PubMed PMID: 16643020.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sesquiterpene lactones from Inula britannica and their cytotoxic and apoptotic effects on human cancer cell lines. AU - Bai,Naisheng, AU - Lai,Ching-Shu, AU - He,Kan, AU - Zhou,Zhu, AU - Zhang,Li, AU - Quan,Zheng, AU - Zhu,Nanqun, AU - Zheng,Qun Yi, AU - Pan,Min-Hsiung, AU - Ho,Chi-Tang, PY - 2006/4/29/pubmed PY - 2006/6/22/medline PY - 2006/4/29/entrez SP - 531 EP - 5 JF - Journal of natural products JO - J Nat Prod VL - 69 IS - 4 N2 - Three new sesquiterpenes (1-3), together with four known sesquiterpene lactones, were isolated from the flowers of Inula britannica var. chinensis. Structures were established on the basis of high-field 1D and 2D NMR methods supported by HRMS. All sesquiterpene lactones were tested for cytotoxicity as well as apoptotic ratio in human COLO 205, HT 29, HL-60, and AGS cancer cells. Compounds 3 and 4, two alpha-methylene gamma-lactone-bearing sesquiterpenes, were modestly active in these assays. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/16643020/Sesquiterpene_lactones_from_Inula_britannica_and_their_cytotoxic_and_apoptotic_effects_on_human_cancer_cell_lines_ DB - PRIME DP - Unbound Medicine ER -