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Interleukin-8 levels in seminal plasma in chronic prostatitis/chronic pelvic pain syndrome and nonspecific urethritis.
BJU Int. 2006 May; 97(5):1043-6.BI

Abstract

OBJECTIVE

To investigate whether a range of cytokines were detectable in the seminal plasma and urine of men with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and nonspecific urethritis (NSU), and whether cytokine levels correlated with symptom severity in CP/CPPS.

PATIENTS AND METHODS

In all, 87 men participated, 33 with CP/CPPS, 31 with NSU, and 23 controls. Interleukin (IL)-1beta, IL-2, IL-6, IL-8 and IL-10 were measured in seminal plasma and first pass urine, and the results were correlated with scores for pain, urinary symptoms and quality-of-life impact using a validated symptom index, the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI).

RESULTS

Seminal plasma levels of IL-8 were higher in men with CP/CPPS and NSU than in controls (P < 0.001), and the levels correlated with NIH-CPSI symptom scores in men with CP/CPPS. There were no significant differences in urinary IL-8 levels in the three groups, and no significant differences in levels of the other cytokines in either semen or urine.

CONCLUSION

Semen IL-8 levels correlate with subjective symptoms in men with CP/CPPS. IL-8 might contribute to the pathophysiology of CP/CPPS and NSU, and elevated levels might be a useful marker of the condition.

Authors+Show Affiliations

Department of Clinical Development Sciences (Genitourinary Medicine), St George's, University of London, London. akhadra@sgul.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16643489

Citation

Khadra, Abbas, et al. "Interleukin-8 Levels in Seminal Plasma in Chronic Prostatitis/chronic Pelvic Pain Syndrome and Nonspecific Urethritis." BJU International, vol. 97, no. 5, 2006, pp. 1043-6.
Khadra A, Fletcher P, Luzzi G, et al. Interleukin-8 levels in seminal plasma in chronic prostatitis/chronic pelvic pain syndrome and nonspecific urethritis. BJU Int. 2006;97(5):1043-6.
Khadra, A., Fletcher, P., Luzzi, G., Shattock, R., & Hay, P. (2006). Interleukin-8 levels in seminal plasma in chronic prostatitis/chronic pelvic pain syndrome and nonspecific urethritis. BJU International, 97(5), 1043-6.
Khadra A, et al. Interleukin-8 Levels in Seminal Plasma in Chronic Prostatitis/chronic Pelvic Pain Syndrome and Nonspecific Urethritis. BJU Int. 2006;97(5):1043-6. PubMed PMID: 16643489.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interleukin-8 levels in seminal plasma in chronic prostatitis/chronic pelvic pain syndrome and nonspecific urethritis. AU - Khadra,Abbas, AU - Fletcher,Patricia, AU - Luzzi,Graz, AU - Shattock,Robin, AU - Hay,Phillip, PY - 2006/4/29/pubmed PY - 2006/6/10/medline PY - 2006/4/29/entrez SP - 1043 EP - 6 JF - BJU international JO - BJU Int. VL - 97 IS - 5 N2 - OBJECTIVE: To investigate whether a range of cytokines were detectable in the seminal plasma and urine of men with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and nonspecific urethritis (NSU), and whether cytokine levels correlated with symptom severity in CP/CPPS. PATIENTS AND METHODS: In all, 87 men participated, 33 with CP/CPPS, 31 with NSU, and 23 controls. Interleukin (IL)-1beta, IL-2, IL-6, IL-8 and IL-10 were measured in seminal plasma and first pass urine, and the results were correlated with scores for pain, urinary symptoms and quality-of-life impact using a validated symptom index, the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI). RESULTS: Seminal plasma levels of IL-8 were higher in men with CP/CPPS and NSU than in controls (P < 0.001), and the levels correlated with NIH-CPSI symptom scores in men with CP/CPPS. There were no significant differences in urinary IL-8 levels in the three groups, and no significant differences in levels of the other cytokines in either semen or urine. CONCLUSION: Semen IL-8 levels correlate with subjective symptoms in men with CP/CPPS. IL-8 might contribute to the pathophysiology of CP/CPPS and NSU, and elevated levels might be a useful marker of the condition. SN - 1464-4096 UR - https://www.unboundmedicine.com/medline/citation/16643489/Interleukin_8_levels_in_seminal_plasma_in_chronic_prostatitis/chronic_pelvic_pain_syndrome_and_nonspecific_urethritis_ L2 - https://doi.org/10.1111/j.1464-410X.2006.06133.x DB - PRIME DP - Unbound Medicine ER -