Tags

Type your tag names separated by a space and hit enter

Ghrelin concentrations and cardiac vagal tone are decreased after pharmacologic and cognitive-behavioral treatment in patients with bulimia nervosa.
Horm Behav. 2006 Aug; 50(2):261-5.HB

Abstract

Patients with bulimia nervosa (BN) have bulimic and depressive symptoms, which have been associated with abnormalities in the neuroendocrine and vagal systems. Subjects included twenty-four female drug-free outpatients with BN that were selected from patients seeking treatment for eating behavior in our hospital along with twenty-five age-matched healthy females who served as controls. We investigated ghrelin and leptin levels, cardiac vagal tone and sympathovagal balance, frequency of sets of binge-eating and vomiting episodes per week and the Profile of Mood States (POMS) depression scale in BN before and after a 16-week administration of the serotonin selective reuptake inhibitor (SSRI) paroxetine combined with cognitive-behavioral therapy. Compared to controls, the BN group had higher ghrelin levels and resting cardiac vagal tone, and lower leptin levels and resting cardiac sympathovagal balance before treatment, although there was a significant difference between the two groups for the body mass index (BMI). The elevated ghrelin levels (301.7 +/- 18.9 pmol/l, mean +/- SEM vs. 202.8 +/- 15.6 pmol/l, P < 0.01), cardiac vagal tone (2246.4 +/- 335.5 ms(2) vs. 1128.5 +/- 193.3 ms(2), P < 0.01), frequency of sets of binge-eating and purging episodes and T scores for the POMS depression scale were all significantly decreased after treatment despite similar BMI, percent body fat and leptin levels. In close association with cardiac vagal function and ghrelin recoveries, abnormal eating behavior and depressive symptoms improved, indicating the usefulness of these indexes in the assessment of clinical condition and therapeutic efficacy in BN.

Authors+Show Affiliations

Department of Psychosomatic Medicine, Respiratory and Stress Care Center, Kagoshima University Hospital, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan. muneki@m3.kufm.kagoshima-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16643914

Citation

Tanaka, Muneki, et al. "Ghrelin Concentrations and Cardiac Vagal Tone Are Decreased After Pharmacologic and Cognitive-behavioral Treatment in Patients With Bulimia Nervosa." Hormones and Behavior, vol. 50, no. 2, 2006, pp. 261-5.
Tanaka M, Nakahara T, Muranaga T, et al. Ghrelin concentrations and cardiac vagal tone are decreased after pharmacologic and cognitive-behavioral treatment in patients with bulimia nervosa. Horm Behav. 2006;50(2):261-5.
Tanaka, M., Nakahara, T., Muranaga, T., Kojima, S., Yasuhara, D., Ueno, H., Nakazato, M., & Inui, A. (2006). Ghrelin concentrations and cardiac vagal tone are decreased after pharmacologic and cognitive-behavioral treatment in patients with bulimia nervosa. Hormones and Behavior, 50(2), 261-5.
Tanaka M, et al. Ghrelin Concentrations and Cardiac Vagal Tone Are Decreased After Pharmacologic and Cognitive-behavioral Treatment in Patients With Bulimia Nervosa. Horm Behav. 2006;50(2):261-5. PubMed PMID: 16643914.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ghrelin concentrations and cardiac vagal tone are decreased after pharmacologic and cognitive-behavioral treatment in patients with bulimia nervosa. AU - Tanaka,Muneki, AU - Nakahara,Toshihiro, AU - Muranaga,Tetsuro, AU - Kojima,Shinya, AU - Yasuhara,Daisuke, AU - Ueno,Hiroaki, AU - Nakazato,Masamitsu, AU - Inui,Akio, Y1 - 2006/04/27/ PY - 2005/10/25/received PY - 2006/02/03/revised PY - 2006/03/17/accepted PY - 2006/4/29/pubmed PY - 2006/8/30/medline PY - 2006/4/29/entrez SP - 261 EP - 5 JF - Hormones and behavior JO - Horm Behav VL - 50 IS - 2 N2 - Patients with bulimia nervosa (BN) have bulimic and depressive symptoms, which have been associated with abnormalities in the neuroendocrine and vagal systems. Subjects included twenty-four female drug-free outpatients with BN that were selected from patients seeking treatment for eating behavior in our hospital along with twenty-five age-matched healthy females who served as controls. We investigated ghrelin and leptin levels, cardiac vagal tone and sympathovagal balance, frequency of sets of binge-eating and vomiting episodes per week and the Profile of Mood States (POMS) depression scale in BN before and after a 16-week administration of the serotonin selective reuptake inhibitor (SSRI) paroxetine combined with cognitive-behavioral therapy. Compared to controls, the BN group had higher ghrelin levels and resting cardiac vagal tone, and lower leptin levels and resting cardiac sympathovagal balance before treatment, although there was a significant difference between the two groups for the body mass index (BMI). The elevated ghrelin levels (301.7 +/- 18.9 pmol/l, mean +/- SEM vs. 202.8 +/- 15.6 pmol/l, P < 0.01), cardiac vagal tone (2246.4 +/- 335.5 ms(2) vs. 1128.5 +/- 193.3 ms(2), P < 0.01), frequency of sets of binge-eating and purging episodes and T scores for the POMS depression scale were all significantly decreased after treatment despite similar BMI, percent body fat and leptin levels. In close association with cardiac vagal function and ghrelin recoveries, abnormal eating behavior and depressive symptoms improved, indicating the usefulness of these indexes in the assessment of clinical condition and therapeutic efficacy in BN. SN - 0018-506X UR - https://www.unboundmedicine.com/medline/citation/16643914/Ghrelin_concentrations_and_cardiac_vagal_tone_are_decreased_after_pharmacologic_and_cognitive_behavioral_treatment_in_patients_with_bulimia_nervosa_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0018-506X(06)00060-2 DB - PRIME DP - Unbound Medicine ER -