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Fetuin-A and kidney function in persons with coronary artery disease--data from the Heart and Soul Study.
Nephrol Dial Transplant. 2006 Aug; 21(8):2144-51.ND

Abstract

BACKGROUND

Fetuin-A is a serum protein that inhibits ectopic vascular calcification and is present in lower concentrations in end-stage renal disease than in healthy controls. Whether fetuin-A concentrations are also lower in the setting of mild-to-moderate chronic kidney disease (CKD) is unknown.

METHODS

We evaluated the associations of several parameters of kidney function including measured 24 h urinary creatinine clearance (CrCl), estimated glomerular filtration rate (GFR) by the Mayo Clinic quadratic GFR equation (qGFR), serum cystatin-C concentrations, and urinary albumin-to-creatinine ratio with serum fetuin-A concentrations in 970 outpatients with coronary artery disease. We used general linear models to determine the adjusted mean fetuin-A concentrations within each kidney function category.

RESULTS

The mean age of the study sample was 67 years, 82% were male, 71% had hypertension and 26% had diabetes mellitus. In adjusted analysis, we observed no significant differences in mean fetuin-A concentrations across groups defined by CrCl, qGFR, or albumin-to-creatinine ratio groups. For example, adjusted mean fetuin-A concentrations were 0.66 g/l in participants with CrCl > 90, 60-90 and 45-60 ml/min/1.73 m(2), and 0.65 g/l in participants with CrCl < 45 ml/min/1.73 m(2). Higher serum cystatin-C (indicating worse kidney function) was associated with higher adjusted mean serum fetuin-A concentrations (lowest quartile 0.62 g/l, highest quartile 0.68 g/l; P for trend <0.001).

CONCLUSIONS

Among ambulatory patients with coronary artery disease, there is no evidence that mild-to-moderate CKD is associated with lower concentrations of serum fetuin-A compared with persons with normal renal function. The mechanisms explaining the association between CKD and vascular calcification remain elusive.

Authors+Show Affiliations

Division of Nephrology, Department of Medicine, Box 0532, HSE 672, University of California, San Francisco, San Francisco, CA 94143-0532, USA. jix@medicine.ucsf.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

16644775

Citation

Ix, Joachim H., et al. "Fetuin-A and Kidney Function in Persons With Coronary Artery Disease--data From the Heart and Soul Study." Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, vol. 21, no. 8, 2006, pp. 2144-51.
Ix JH, Chertow GM, Shlipak MG, et al. Fetuin-A and kidney function in persons with coronary artery disease--data from the Heart and Soul Study. Nephrol Dial Transplant. 2006;21(8):2144-51.
Ix, J. H., Chertow, G. M., Shlipak, M. G., Brandenburg, V. M., Ketteler, M., & Whooley, M. A. (2006). Fetuin-A and kidney function in persons with coronary artery disease--data from the Heart and Soul Study. Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, 21(8), 2144-51.
Ix JH, et al. Fetuin-A and Kidney Function in Persons With Coronary Artery Disease--data From the Heart and Soul Study. Nephrol Dial Transplant. 2006;21(8):2144-51. PubMed PMID: 16644775.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fetuin-A and kidney function in persons with coronary artery disease--data from the Heart and Soul Study. AU - Ix,Joachim H, AU - Chertow,Glenn M, AU - Shlipak,Michael G, AU - Brandenburg,Vincent M, AU - Ketteler,Markus, AU - Whooley,Mary A, Y1 - 2006/04/27/ PY - 2006/4/29/pubmed PY - 2007/4/5/medline PY - 2006/4/29/entrez SP - 2144 EP - 51 JF - Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association JO - Nephrol Dial Transplant VL - 21 IS - 8 N2 - BACKGROUND: Fetuin-A is a serum protein that inhibits ectopic vascular calcification and is present in lower concentrations in end-stage renal disease than in healthy controls. Whether fetuin-A concentrations are also lower in the setting of mild-to-moderate chronic kidney disease (CKD) is unknown. METHODS: We evaluated the associations of several parameters of kidney function including measured 24 h urinary creatinine clearance (CrCl), estimated glomerular filtration rate (GFR) by the Mayo Clinic quadratic GFR equation (qGFR), serum cystatin-C concentrations, and urinary albumin-to-creatinine ratio with serum fetuin-A concentrations in 970 outpatients with coronary artery disease. We used general linear models to determine the adjusted mean fetuin-A concentrations within each kidney function category. RESULTS: The mean age of the study sample was 67 years, 82% were male, 71% had hypertension and 26% had diabetes mellitus. In adjusted analysis, we observed no significant differences in mean fetuin-A concentrations across groups defined by CrCl, qGFR, or albumin-to-creatinine ratio groups. For example, adjusted mean fetuin-A concentrations were 0.66 g/l in participants with CrCl > 90, 60-90 and 45-60 ml/min/1.73 m(2), and 0.65 g/l in participants with CrCl < 45 ml/min/1.73 m(2). Higher serum cystatin-C (indicating worse kidney function) was associated with higher adjusted mean serum fetuin-A concentrations (lowest quartile 0.62 g/l, highest quartile 0.68 g/l; P for trend <0.001). CONCLUSIONS: Among ambulatory patients with coronary artery disease, there is no evidence that mild-to-moderate CKD is associated with lower concentrations of serum fetuin-A compared with persons with normal renal function. The mechanisms explaining the association between CKD and vascular calcification remain elusive. SN - 0931-0509 UR - https://www.unboundmedicine.com/medline/citation/16644775/Fetuin_A_and_kidney_function_in_persons_with_coronary_artery_disease__data_from_the_Heart_and_Soul_Study_ L2 - https://academic.oup.com/ndt/article-lookup/doi/10.1093/ndt/gfl204 DB - PRIME DP - Unbound Medicine ER -