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Renal function and 25-hydroxyvitamin D concentrations predict parathyroid hormone levels in renal transplant patients.
Nephrol Dial Transplant. 2006 Sep; 21(9):2621-4.ND

Abstract

BACKGROUND

Recent guidelines suggest supplementation with ergocalciferol (vitamin D(2)) in chronic kidney disease stages 3 and 4 patients with elevated parathyroid hormone (PTH) levels and 25-hydroxyvitamin D (25OHD) levels <75 nmol/l. These guidelines are also applied to renal transplant patients. However, the prevalence rates of 25OHD deficiency and its association with PTH levels in renal transplant populations have not been extensively examined. We aimed to document the prevalence rates of 25OHD deficiency [defined by serum levels <40 nmol/l (<16 ng/ml)] and insufficiency [<75 nmol/l (<30 ng/ml)] in a single renal transplant centre, and examine its relationship with PTH levels.

METHODS

Serum 25OHD and PTH concentrations were measured in 419 transplant patients attending a single renal transplant clinic over a 4-month period. Demographic and biochemical data were also collected, including serum creatinine, calcium, phosphate and albumin. Simple and multiple linear regression analysis were performed.

RESULTS

In 27.3% of the patients, 25OHD deficiency was present, and 75.5% had insufficiency. On univariate analysis, 25OHD, serum albumin and estimated glomerular filtration rate (eGFR) were significantly associated with PTH levels (P < 0.0001, P = 0.004 and P < 0.0001, respectively). Multiple linear regression demonstrated that only 25OHD, eGFR and serum phosphate were significantly predictive of PTH levels (R(2) = 0.19, P < 0.0001). In this model, a 75 nmol/l increase in 25OHD will only result in a maximal reduction in PTH of 2.0 pmol/l.

CONCLUSIONS

We conclude that 25OHD deficiency and insufficiency are common in renal transplant patients and may exacerbate secondary hyperparathyroidism. However, 25OHD, eGFR and phosphate only account for 19% of the variability in PTH levels. In addition, even a large increase in serum 25OHD levels is likely to result in only a small reduction in PTH. Therefore, alternative approaches to managing hyperparathyroidism in renal transplant recipients rather than supplementation with ergocalciferol are warranted.

Authors+Show Affiliations

Boudville NC
School of Medicine and Pharmacology, University of Western Australia, Sir Charles Gairdner Hospital, Perth, WA, Australia. nboudvil@cyllene.uwa.edu.au
Hodsman AB
No affiliation info available

MeSH

BiomarkersCreatinineEnzyme-Linked Immunosorbent AssayFemaleFollow-Up StudiesGlomerular Filtration RateHumansHyperparathyroidism, SecondaryKidney Failure, ChronicKidney TransplantationMaleMiddle AgedParathyroid HormonePrognosisRadioimmunoassayRetrospective StudiesVitamin DVitamin D Deficiency

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16644777

Citation

Boudville, Neil C., and Anthony B. Hodsman. "Renal Function and 25-hydroxyvitamin D Concentrations Predict Parathyroid Hormone Levels in Renal Transplant Patients." Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, vol. 21, no. 9, 2006, pp. 2621-4.
Boudville NC, Hodsman AB. Renal function and 25-hydroxyvitamin D concentrations predict parathyroid hormone levels in renal transplant patients. Nephrol Dial Transplant. 2006;21(9):2621-4.
Boudville, N. C., & Hodsman, A. B. (2006). Renal function and 25-hydroxyvitamin D concentrations predict parathyroid hormone levels in renal transplant patients. Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, 21(9), 2621-4.
Boudville NC, Hodsman AB. Renal Function and 25-hydroxyvitamin D Concentrations Predict Parathyroid Hormone Levels in Renal Transplant Patients. Nephrol Dial Transplant. 2006;21(9):2621-4. PubMed PMID: 16644777.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Renal function and 25-hydroxyvitamin D concentrations predict parathyroid hormone levels in renal transplant patients. AU - Boudville,Neil C, AU - Hodsman,Anthony B, Y1 - 2006/04/27/ PY - 2006/4/29/pubmed PY - 2006/10/13/medline PY - 2006/4/29/entrez SP - 2621 EP - 4 JF - Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association JO - Nephrol Dial Transplant VL - 21 IS - 9 N2 - BACKGROUND: Recent guidelines suggest supplementation with ergocalciferol (vitamin D(2)) in chronic kidney disease stages 3 and 4 patients with elevated parathyroid hormone (PTH) levels and 25-hydroxyvitamin D (25OHD) levels <75 nmol/l. These guidelines are also applied to renal transplant patients. However, the prevalence rates of 25OHD deficiency and its association with PTH levels in renal transplant populations have not been extensively examined. We aimed to document the prevalence rates of 25OHD deficiency [defined by serum levels <40 nmol/l (<16 ng/ml)] and insufficiency [<75 nmol/l (<30 ng/ml)] in a single renal transplant centre, and examine its relationship with PTH levels. METHODS: Serum 25OHD and PTH concentrations were measured in 419 transplant patients attending a single renal transplant clinic over a 4-month period. Demographic and biochemical data were also collected, including serum creatinine, calcium, phosphate and albumin. Simple and multiple linear regression analysis were performed. RESULTS: In 27.3% of the patients, 25OHD deficiency was present, and 75.5% had insufficiency. On univariate analysis, 25OHD, serum albumin and estimated glomerular filtration rate (eGFR) were significantly associated with PTH levels (P < 0.0001, P = 0.004 and P < 0.0001, respectively). Multiple linear regression demonstrated that only 25OHD, eGFR and serum phosphate were significantly predictive of PTH levels (R(2) = 0.19, P < 0.0001). In this model, a 75 nmol/l increase in 25OHD will only result in a maximal reduction in PTH of 2.0 pmol/l. CONCLUSIONS: We conclude that 25OHD deficiency and insufficiency are common in renal transplant patients and may exacerbate secondary hyperparathyroidism. However, 25OHD, eGFR and phosphate only account for 19% of the variability in PTH levels. In addition, even a large increase in serum 25OHD levels is likely to result in only a small reduction in PTH. Therefore, alternative approaches to managing hyperparathyroidism in renal transplant recipients rather than supplementation with ergocalciferol are warranted. SN - 0931-0509 UR - https://www.unboundmedicine.com/medline/citation/16644777/Renal_function_and_25_hydroxyvitamin_D_concentrations_predict_parathyroid_hormone_levels_in_renal_transplant_patients_ DB - PRIME DP - Unbound Medicine ER -