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Effectiveness of inactivated influenza vaccine for prevention of otitis media in children.
Pediatr Infect Dis J 2006; 25(5):401-4PI

Abstract

OBJECTIVE

The objective of this study was to evaluate the effectiveness of inactivated influenza vaccine in preventing acute otitis media (AOM) and otitis media with effusion (OME) in children aged 6 to 60 months who attend day care.

STUDY DESIGN

This prospective, single-blind study was conducted in 8 day care centers in Ankara, Turkey. One hundred nineteen (61 vaccinated and 58 unvaccinated against influenza) healthy children were examined at study entry and at 6-week intervals for 6 months by the same 2 otorhinolaryngologists who were blinded about the vaccination status of the children. The frequency of AOM and OME is compared between the 2 groups and the effect of influenza season on frequency of episodes was evaluated. Based on national influenza laboratory data, the influenza season was determined to be the period between December 15, 2003, and January 31, 2004.

RESULT

The frequencies of AOM, OME and total otitis media episodes in vaccinated children were 2.3%, 22.8% and 25.2%, respectively, and these frequencies were 5.2%, 31.1% and 36.3% in the unvaccinated group. The difference was statistically significant (P < 0.01). This difference was especially prominent in the influenza season (P < 0.05).

CONCLUSION

Influenza vaccine is effective in reducing AOM and OME episodes in 6- to 60-month-old day care children, especially during influenza season.

Authors+Show Affiliations

Department of Pediatrics, Gazi University Medical Faculty, Ankara, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

16645502

Citation

Ozgur, Senem Konuk, et al. "Effectiveness of Inactivated Influenza Vaccine for Prevention of Otitis Media in Children." The Pediatric Infectious Disease Journal, vol. 25, no. 5, 2006, pp. 401-4.
Ozgur SK, Beyazova U, Kemaloglu YK, et al. Effectiveness of inactivated influenza vaccine for prevention of otitis media in children. Pediatr Infect Dis J. 2006;25(5):401-4.
Ozgur, S. K., Beyazova, U., Kemaloglu, Y. K., Maral, I., Sahin, F., Camurdan, A. D., ... Tuzun, H. (2006). Effectiveness of inactivated influenza vaccine for prevention of otitis media in children. The Pediatric Infectious Disease Journal, 25(5), pp. 401-4.
Ozgur SK, et al. Effectiveness of Inactivated Influenza Vaccine for Prevention of Otitis Media in Children. Pediatr Infect Dis J. 2006;25(5):401-4. PubMed PMID: 16645502.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effectiveness of inactivated influenza vaccine for prevention of otitis media in children. AU - Ozgur,Senem Konuk, AU - Beyazova,Ufuk, AU - Kemaloglu,Yusuf Kemal, AU - Maral,Isil, AU - Sahin,Figen, AU - Camurdan,Aysu Duyan, AU - Kizil,Yusuf, AU - Dinc,Erdem, AU - Tuzun,Hakan, PY - 2006/4/29/pubmed PY - 2006/7/4/medline PY - 2006/4/29/entrez SP - 401 EP - 4 JF - The Pediatric infectious disease journal JO - Pediatr. Infect. Dis. J. VL - 25 IS - 5 N2 - OBJECTIVE: The objective of this study was to evaluate the effectiveness of inactivated influenza vaccine in preventing acute otitis media (AOM) and otitis media with effusion (OME) in children aged 6 to 60 months who attend day care. STUDY DESIGN: This prospective, single-blind study was conducted in 8 day care centers in Ankara, Turkey. One hundred nineteen (61 vaccinated and 58 unvaccinated against influenza) healthy children were examined at study entry and at 6-week intervals for 6 months by the same 2 otorhinolaryngologists who were blinded about the vaccination status of the children. The frequency of AOM and OME is compared between the 2 groups and the effect of influenza season on frequency of episodes was evaluated. Based on national influenza laboratory data, the influenza season was determined to be the period between December 15, 2003, and January 31, 2004. RESULT: The frequencies of AOM, OME and total otitis media episodes in vaccinated children were 2.3%, 22.8% and 25.2%, respectively, and these frequencies were 5.2%, 31.1% and 36.3% in the unvaccinated group. The difference was statistically significant (P < 0.01). This difference was especially prominent in the influenza season (P < 0.05). CONCLUSION: Influenza vaccine is effective in reducing AOM and OME episodes in 6- to 60-month-old day care children, especially during influenza season. SN - 0891-3668 UR - https://www.unboundmedicine.com/medline/citation/16645502/Effectiveness_of_inactivated_influenza_vaccine_for_prevention_of_otitis_media_in_children_ L2 - http://dx.doi.org/10.1097/01.inf.0000217370.83948.51 DB - PRIME DP - Unbound Medicine ER -