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Clinical studies of red clover (Trifolium pratense) dietary supplements in menopause: a literature review.
Menopause. 2006 Mar-Apr; 13(2):251-64.M

Abstract

Red clover (Trifolium pratense L., Fabaceae) botanical dietary supplements have received much attention recently for their potential use in the treatment of menopause symptoms, maintenance/improvement of bone and cardiovascular health, and reported benign effects on the breast and endometrium. Literature searches of four computerized databases were run to identify clinical studies of red clover botanical dietary supplements. The manufacturer of the red clover products used in the majority of the studies was contacted for unpublished information and/or clarification regarding the chemical content of their products. Red clover studies were reviewed that pertained to women's health or menopause. Clinical evidence is presently lacking to support the efficacy of semipurified red clover isoflavone extracts for alleviation of climacteric vasomotor symptoms or reduction of low-density lipoprotein levels in the blood. Furthermore, the safety of use of red clover isoflavone supplements in patients with breast or endometrial cancer has not been established. Limited evidence suggests possible efficacy in maintenance of bone health and improvement of arterial compliance, a risk factor for atherosclerosis. This literature review covers red clover botanical dietary supplement clinical studies having a possible impact on the health care of mature and menopausal women, and provides historical perspective regarding the traditional uses of red clover.

Authors+Show Affiliations

Booth NL
UIC/NIH Center for Botanical Dietary Supplements Research, Program for Collaborative Research in the Pharmaceutical Sciences (PCRPS), University of Illinois at Chicago, Chicago, IL 60612, USA.
Piersen CE
No affiliation info available
Banuvar S
No affiliation info available
Geller SE
No affiliation info available
Shulman LP
No affiliation info available
Farnsworth NR
No affiliation info available

MeSH

AnimalsAntineoplastic AgentsBiological ProductsBone DensityBreastClinical Trials as TopicDietary SupplementsFemaleGenisteinHot FlashesHumansIsoflavonesLipidsMenopauseOsteoporosis, PostmenopausalPhytoestrogensPhytotherapyPlant PreparationsThyroid GlandTrifoliumVasomotor System

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

16645539

Citation

Booth, Nancy L., et al. "Clinical Studies of Red Clover (Trifolium Pratense) Dietary Supplements in Menopause: a Literature Review." Menopause (New York, N.Y.), vol. 13, no. 2, 2006, pp. 251-64.
Booth NL, Piersen CE, Banuvar S, et al. Clinical studies of red clover (Trifolium pratense) dietary supplements in menopause: a literature review. Menopause. 2006;13(2):251-64.
Booth, N. L., Piersen, C. E., Banuvar, S., Geller, S. E., Shulman, L. P., & Farnsworth, N. R. (2006). Clinical studies of red clover (Trifolium pratense) dietary supplements in menopause: a literature review. Menopause (New York, N.Y.), 13(2), 251-64.
Booth NL, et al. Clinical Studies of Red Clover (Trifolium Pratense) Dietary Supplements in Menopause: a Literature Review. Menopause. 2006 Mar-Apr;13(2):251-64. PubMed PMID: 16645539.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical studies of red clover (Trifolium pratense) dietary supplements in menopause: a literature review. AU - Booth,Nancy L, AU - Piersen,Colleen E, AU - Banuvar,Suzanne, AU - Geller,Stacie E, AU - Shulman,Lee P, AU - Farnsworth,Norman R, PY - 2006/4/29/pubmed PY - 2008/1/19/medline PY - 2006/4/29/entrez SP - 251 EP - 64 JF - Menopause (New York, N.Y.) JO - Menopause VL - 13 IS - 2 N2 - Red clover (Trifolium pratense L., Fabaceae) botanical dietary supplements have received much attention recently for their potential use in the treatment of menopause symptoms, maintenance/improvement of bone and cardiovascular health, and reported benign effects on the breast and endometrium. Literature searches of four computerized databases were run to identify clinical studies of red clover botanical dietary supplements. The manufacturer of the red clover products used in the majority of the studies was contacted for unpublished information and/or clarification regarding the chemical content of their products. Red clover studies were reviewed that pertained to women's health or menopause. Clinical evidence is presently lacking to support the efficacy of semipurified red clover isoflavone extracts for alleviation of climacteric vasomotor symptoms or reduction of low-density lipoprotein levels in the blood. Furthermore, the safety of use of red clover isoflavone supplements in patients with breast or endometrial cancer has not been established. Limited evidence suggests possible efficacy in maintenance of bone health and improvement of arterial compliance, a risk factor for atherosclerosis. This literature review covers red clover botanical dietary supplement clinical studies having a possible impact on the health care of mature and menopausal women, and provides historical perspective regarding the traditional uses of red clover. SN - 1072-3714 UR - https://www.unboundmedicine.com/medline/citation/16645539/Clinical_studies_of_red_clover__Trifolium_pratense__dietary_supplements_in_menopause:_a_literature_review_ DB - PRIME DP - Unbound Medicine ER -