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Undercarboxylated osteocalcin concentration in postmenopausal women receiving hormone therapy daily and on alternate days.
Menopause. 2006 Mar-Apr; 13(2):314-22.M

Abstract

OBJECTIVE

Undercarboxylated osteocalcin (ucOC) is a sensitive marker of vitamin K status. The authors examined the difference in serum ucOC concentrations in postmenopausal women receiving hormone therapy (HT) daily and on alternate days, and assessed the association between ucOC and triglyceride concentrations, which are related to the transport of vitamin K.

DESIGN

Seventy-three postmenopausal women were recruited for this study. Thirty-seven women received 0.625 mg of conjugated equine estrogens (CEE) and 2.5 mg of medroxyprogesterone acetate (MPA) daily, and 36 women received 0.625 mg of CEE and 2.5 mg of MPA on alternate days. The concentrations of serum ucOC, bone turnover markers, lipid profiles, and hormones were measured before and after 12 months of HT.

RESULTS

The ucOC concentration in women taking HT daily was significantly (P < 0.01) lower than that in women taking HT on alternate days. Serum ucOC concentrations during HT showed a significant (P < 0.01) inverse correlation with estradiol concentrations during HT. Serum estradiol concentrations during HT showed a significant (P < 0.01) positive correlation with triglyceride concentrations during HT. Furthermore, ucOC concentrations during HT showed a significant (P < 0.05) inverse correlation with triglyceride concentrations in women receiving HT.

CONCLUSIONS

The effect of HT on alternate days on ucOC concentration was weaker than the effect of HT daily. In addition, ucOC concentration after 12 months of HT daily might be decreased due to the conversion of ucOC to carboxylated OC by the effect of vitamin K through increased triglyceride levels induced by oral CEE.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, School of Medicine, University of Tokushima, Tokushima, Japan. yashi@clin.med.tokushima-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

16645545

Citation

Yasui, Toshiyuki, et al. "Undercarboxylated Osteocalcin Concentration in Postmenopausal Women Receiving Hormone Therapy Daily and On Alternate Days." Menopause (New York, N.Y.), vol. 13, no. 2, 2006, pp. 314-22.
Yasui T, Uemura H, Umino Y, et al. Undercarboxylated osteocalcin concentration in postmenopausal women receiving hormone therapy daily and on alternate days. Menopause. 2006;13(2):314-22.
Yasui, T., Uemura, H., Umino, Y., Yamada, M., Kuwahara, A., Matsuzaki, T., Maegawa, M., Furumoto, H., Miura, M., & Irahara, M. (2006). Undercarboxylated osteocalcin concentration in postmenopausal women receiving hormone therapy daily and on alternate days. Menopause (New York, N.Y.), 13(2), 314-22.
Yasui T, et al. Undercarboxylated Osteocalcin Concentration in Postmenopausal Women Receiving Hormone Therapy Daily and On Alternate Days. Menopause. 2006 Mar-Apr;13(2):314-22. PubMed PMID: 16645545.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Undercarboxylated osteocalcin concentration in postmenopausal women receiving hormone therapy daily and on alternate days. AU - Yasui,Toshiyuki, AU - Uemura,Hirokazu, AU - Umino,Yuka, AU - Yamada,Masayo, AU - Kuwahara,Akira, AU - Matsuzaki,Toshiya, AU - Maegawa,Masahiko, AU - Furumoto,Hiroyuki, AU - Miura,Masakazu, AU - Irahara,Minoru, PY - 2006/4/29/pubmed PY - 2008/1/19/medline PY - 2006/4/29/entrez SP - 314 EP - 22 JF - Menopause (New York, N.Y.) JO - Menopause VL - 13 IS - 2 N2 - OBJECTIVE: Undercarboxylated osteocalcin (ucOC) is a sensitive marker of vitamin K status. The authors examined the difference in serum ucOC concentrations in postmenopausal women receiving hormone therapy (HT) daily and on alternate days, and assessed the association between ucOC and triglyceride concentrations, which are related to the transport of vitamin K. DESIGN: Seventy-three postmenopausal women were recruited for this study. Thirty-seven women received 0.625 mg of conjugated equine estrogens (CEE) and 2.5 mg of medroxyprogesterone acetate (MPA) daily, and 36 women received 0.625 mg of CEE and 2.5 mg of MPA on alternate days. The concentrations of serum ucOC, bone turnover markers, lipid profiles, and hormones were measured before and after 12 months of HT. RESULTS: The ucOC concentration in women taking HT daily was significantly (P < 0.01) lower than that in women taking HT on alternate days. Serum ucOC concentrations during HT showed a significant (P < 0.01) inverse correlation with estradiol concentrations during HT. Serum estradiol concentrations during HT showed a significant (P < 0.01) positive correlation with triglyceride concentrations during HT. Furthermore, ucOC concentrations during HT showed a significant (P < 0.05) inverse correlation with triglyceride concentrations in women receiving HT. CONCLUSIONS: The effect of HT on alternate days on ucOC concentration was weaker than the effect of HT daily. In addition, ucOC concentration after 12 months of HT daily might be decreased due to the conversion of ucOC to carboxylated OC by the effect of vitamin K through increased triglyceride levels induced by oral CEE. SN - 1072-3714 UR - https://www.unboundmedicine.com/medline/citation/16645545/Undercarboxylated_osteocalcin_concentration_in_postmenopausal_women_receiving_hormone_therapy_daily_and_on_alternate_days_ L2 - https://doi.org/10.1097/01.gme.0000177908.40257.cf DB - PRIME DP - Unbound Medicine ER -