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Body weight and postmenopausal breast cancer risk defined by estrogen and progesterone receptor status among Swedish women: A prospective cohort study.

Abstract

Although obesity is one of the established risk factors for postmenopausal breast cancer, it is not clear whether this positive association differs across estrogen receptor (ER) and progesterone receptor (PR) status of breast tumors. We evaluated the association between body weight and ER/PR defined breast cancer risk stratified by postmenopausal hormone (PMH) use and a family history of breast cancer in the population-based Swedish Mammography Screening Cohort comprising 51,823 postmenopausal women. Relative body weight was measured by body mass index (kg/m2) based on self-reported weight and height collected in 1987 and 1997. Relative risks (RRs) were estimated by hazard ratios derived from Cox proportional hazards regression models. During an average of 8.3-year follow-up, 1,188 invasive breast cancer cases with known ER and PR status were diagnosed. When comparing to normal weight group, we observed a positive association between obesity and risk for the development of ER+ PR+ tumors (RR = 1.67, 95% CI = 1.34-2.07) and an inverse association for the development of all PR- tumors (RR = 0.68, 95% CI = 0.47-0.98). Statistically significant heterogeneity was observed in the RRs between ER+ PR+ tumors and all PR- tumors (p(heterogeneity) < 0.0001). The positive association of obesity with the development of ER+ PR+ tumors was confined to never-users of PMHs (RR = 1.90 (CI 95%:1.38-2.61)) and to those without a family history of breast cancer (RR = 1.82 (CI 95%:1.45-2.29)). Our results support the hypothesis that excess endogenous estrogen due to obesity contributes to an increased risk of ER+ PR+ postmenopausal breast cancer.

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  • Authors+Show Affiliations

    ,

    Division of Nutritional Epidemiology, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

    , , ,

    Source

    International journal of cancer 119:7 2006 Oct 01 pg 1683-9

    MeSH

    Body Weight
    Breast Neoplasms
    Cohort Studies
    Estrogens
    Female
    Humans
    Middle Aged
    Postmenopause
    Prospective Studies
    Receptors, Progesterone
    Risk Factors
    Surveys and Questionnaires
    Sweden

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    16646051

    Citation

    Suzuki, Reiko, et al. "Body Weight and Postmenopausal Breast Cancer Risk Defined By Estrogen and Progesterone Receptor Status Among Swedish Women: a Prospective Cohort Study." International Journal of Cancer, vol. 119, no. 7, 2006, pp. 1683-9.
    Suzuki R, Rylander-Rudqvist T, Ye W, et al. Body weight and postmenopausal breast cancer risk defined by estrogen and progesterone receptor status among Swedish women: A prospective cohort study. Int J Cancer. 2006;119(7):1683-9.
    Suzuki, R., Rylander-Rudqvist, T., Ye, W., Saji, S., & Wolk, A. (2006). Body weight and postmenopausal breast cancer risk defined by estrogen and progesterone receptor status among Swedish women: A prospective cohort study. International Journal of Cancer, 119(7), pp. 1683-9.
    Suzuki R, et al. Body Weight and Postmenopausal Breast Cancer Risk Defined By Estrogen and Progesterone Receptor Status Among Swedish Women: a Prospective Cohort Study. Int J Cancer. 2006 Oct 1;119(7):1683-9. PubMed PMID: 16646051.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Body weight and postmenopausal breast cancer risk defined by estrogen and progesterone receptor status among Swedish women: A prospective cohort study. AU - Suzuki,Reiko, AU - Rylander-Rudqvist,Tove, AU - Ye,Weimin, AU - Saji,Shigehira, AU - Wolk,Alicja, PY - 2006/4/29/pubmed PY - 2006/9/22/medline PY - 2006/4/29/entrez SP - 1683 EP - 9 JF - International journal of cancer JO - Int. J. Cancer VL - 119 IS - 7 N2 - Although obesity is one of the established risk factors for postmenopausal breast cancer, it is not clear whether this positive association differs across estrogen receptor (ER) and progesterone receptor (PR) status of breast tumors. We evaluated the association between body weight and ER/PR defined breast cancer risk stratified by postmenopausal hormone (PMH) use and a family history of breast cancer in the population-based Swedish Mammography Screening Cohort comprising 51,823 postmenopausal women. Relative body weight was measured by body mass index (kg/m2) based on self-reported weight and height collected in 1987 and 1997. Relative risks (RRs) were estimated by hazard ratios derived from Cox proportional hazards regression models. During an average of 8.3-year follow-up, 1,188 invasive breast cancer cases with known ER and PR status were diagnosed. When comparing to normal weight group, we observed a positive association between obesity and risk for the development of ER+ PR+ tumors (RR = 1.67, 95% CI = 1.34-2.07) and an inverse association for the development of all PR- tumors (RR = 0.68, 95% CI = 0.47-0.98). Statistically significant heterogeneity was observed in the RRs between ER+ PR+ tumors and all PR- tumors (p(heterogeneity) < 0.0001). The positive association of obesity with the development of ER+ PR+ tumors was confined to never-users of PMHs (RR = 1.90 (CI 95%:1.38-2.61)) and to those without a family history of breast cancer (RR = 1.82 (CI 95%:1.45-2.29)). Our results support the hypothesis that excess endogenous estrogen due to obesity contributes to an increased risk of ER+ PR+ postmenopausal breast cancer. SN - 0020-7136 UR - https://www.unboundmedicine.com/medline/citation/16646051/Body_weight_and_postmenopausal_breast_cancer_risk_defined_by_estrogen_and_progesterone_receptor_status_among_Swedish_women:_A_prospective_cohort_study_ L2 - https://doi.org/10.1002/ijc.22034 DB - PRIME DP - Unbound Medicine ER -