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Oral chlorambucil for extranodal, marginal zone, B-cell lymphoma of mucosa-associated lymphoid tissue of the orbit.
Ophthalmology 2006; 113(7):1209-13O

Abstract

PURPOSE

To report the outcome of oral chlorambucil as a single treatment in patients with orbital mucosa-associated lymphoid tissue (MALT) lymphoma.

DESIGN

Retrospective nonrandomized clinical study.

PARTICIPANTS

Thirty-three patients with isolated orbital MALT lymphoma.

METHODS

Medical records of all patients with histology-verified orbital MALT lymphoma treated with oral chlorambucil at the Royal Melbourne Hospital were reviewed.

MAIN OUTCOME MEASURES

Complete clinical response, partial response, local relapse, systemic extension (distant relapse), and survival.

RESULTS

Thirty-three patients (19 female; mean age, 69 years) participated in the study. Patients received an average of 4 courses of oral chlorambucil with a mean total dose of 600 mg. The lacrimal gland was the most frequent site of occurrence (24%), followed by the conjunctiva, eyelid, and superior orbit. Orbital mass, swelling, and diplopia were common presenting signs. Complete response was noted in 26 patients (79%). In 2 of the patients with complete clinical response, mild residual thickening was noted on follow-up orbital imaging studies. Four patients (12%) showed disease recurrence or relapse. Mean follow-up time was 32 (+/-20) months (range, 8 months-6 years; median, 26 months). None of the patients developed granulocytopenia secondary to chemotherapy, and none suffered significant nausea or vomiting. One patient with malignant transformation died 12 months after diagnosis and initial treatment.

CONCLUSIONS

Systemic chemotherapy with chlorambucil is a reasonable option in patients with orbital MALT lymphoma. It is associated with minimal to no side effects. Additionally, it may be well tolerated by elderly patients and also may treat subclinical disease elsewhere.

Authors+Show Affiliations

Royal Victorian Eye and Ear Hospital, Melbourne, Australia. guybensimon@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

16647129

Citation

Ben Simon, Guy J., et al. "Oral Chlorambucil for Extranodal, Marginal Zone, B-cell Lymphoma of Mucosa-associated Lymphoid Tissue of the Orbit." Ophthalmology, vol. 113, no. 7, 2006, pp. 1209-13.
Ben Simon GJ, Cheung N, McKelvie P, et al. Oral chlorambucil for extranodal, marginal zone, B-cell lymphoma of mucosa-associated lymphoid tissue of the orbit. Ophthalmology. 2006;113(7):1209-13.
Ben Simon, G. J., Cheung, N., McKelvie, P., Fox, R., & McNab, A. A. (2006). Oral chlorambucil for extranodal, marginal zone, B-cell lymphoma of mucosa-associated lymphoid tissue of the orbit. Ophthalmology, 113(7), pp. 1209-13.
Ben Simon GJ, et al. Oral Chlorambucil for Extranodal, Marginal Zone, B-cell Lymphoma of Mucosa-associated Lymphoid Tissue of the Orbit. Ophthalmology. 2006;113(7):1209-13. PubMed PMID: 16647129.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oral chlorambucil for extranodal, marginal zone, B-cell lymphoma of mucosa-associated lymphoid tissue of the orbit. AU - Ben Simon,Guy J, AU - Cheung,Ning, AU - McKelvie,Penny, AU - Fox,Richard, AU - McNab,Alan A, Y1 - 2006/04/27/ PY - 2005/10/21/received PY - 2005/12/19/revised PY - 2006/01/26/accepted PY - 2006/5/2/pubmed PY - 2006/7/21/medline PY - 2006/5/2/entrez SP - 1209 EP - 13 JF - Ophthalmology JO - Ophthalmology VL - 113 IS - 7 N2 - PURPOSE: To report the outcome of oral chlorambucil as a single treatment in patients with orbital mucosa-associated lymphoid tissue (MALT) lymphoma. DESIGN: Retrospective nonrandomized clinical study. PARTICIPANTS: Thirty-three patients with isolated orbital MALT lymphoma. METHODS: Medical records of all patients with histology-verified orbital MALT lymphoma treated with oral chlorambucil at the Royal Melbourne Hospital were reviewed. MAIN OUTCOME MEASURES: Complete clinical response, partial response, local relapse, systemic extension (distant relapse), and survival. RESULTS: Thirty-three patients (19 female; mean age, 69 years) participated in the study. Patients received an average of 4 courses of oral chlorambucil with a mean total dose of 600 mg. The lacrimal gland was the most frequent site of occurrence (24%), followed by the conjunctiva, eyelid, and superior orbit. Orbital mass, swelling, and diplopia were common presenting signs. Complete response was noted in 26 patients (79%). In 2 of the patients with complete clinical response, mild residual thickening was noted on follow-up orbital imaging studies. Four patients (12%) showed disease recurrence or relapse. Mean follow-up time was 32 (+/-20) months (range, 8 months-6 years; median, 26 months). None of the patients developed granulocytopenia secondary to chemotherapy, and none suffered significant nausea or vomiting. One patient with malignant transformation died 12 months after diagnosis and initial treatment. CONCLUSIONS: Systemic chemotherapy with chlorambucil is a reasonable option in patients with orbital MALT lymphoma. It is associated with minimal to no side effects. Additionally, it may be well tolerated by elderly patients and also may treat subclinical disease elsewhere. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/16647129/Oral_chlorambucil_for_extranodal_marginal_zone_B_cell_lymphoma_of_mucosa_associated_lymphoid_tissue_of_the_orbit_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(06)00155-2 DB - PRIME DP - Unbound Medicine ER -