Benefits of combining aripiprazole to clozapine: three case reports.Prog Neuropsychopharmacol Biol Psychiatry. 2006 Aug 30; 30(6):1167-9.PN
A substantial number of patients treated with clozapine shows insufficient response. The author presents the results of adding aripiprazole in patients resistant to clozapine.
Three cases of individuals with psychotic symptoms despite clozapine use and with significant side effects that were treated via this combination are presented. Response was evaluated by clinical assessment.
Good clinical results were obtained in all three patients, with improvement of psychotic symptoms and of some of the side effects of clozapine.
The findings from this case series suggest that adjunctive therapy with aripiprazole can be of benefit for treating clozapine resistant schizophrenic patients.