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Benefits of combining aripiprazole to clozapine: three case reports.
Prog Neuropsychopharmacol Biol Psychiatry. 2006 Aug 30; 30(6):1167-9.PN

Abstract

OBJECTIVE

A substantial number of patients treated with clozapine shows insufficient response. The author presents the results of adding aripiprazole in patients resistant to clozapine.

METHOD

Three cases of individuals with psychotic symptoms despite clozapine use and with significant side effects that were treated via this combination are presented. Response was evaluated by clinical assessment.

RESULTS

Good clinical results were obtained in all three patients, with improvement of psychotic symptoms and of some of the side effects of clozapine.

CONCLUSION

The findings from this case series suggest that adjunctive therapy with aripiprazole can be of benefit for treating clozapine resistant schizophrenic patients.

Authors+Show Affiliations

Rocha FL
Rua dos Otoni, 106, Santa Efigênia, 30150.270, Belo Horizonte, MG, Brazil. rochafl@uol.com.br
Hara C
No affiliation info available

MeSH

AdultAntipsychotic AgentsAripiprazoleClozapineDrug ResistanceDrug Therapy, CombinationHumansMalePiperazinesPsychiatric Status Rating ScalesPsychotic DisordersQuinolonesSchizophrenia, DisorganizedSchizophrenia, Paranoid

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

16647796

Clinical Trial Links

Aripiprazole Augmentation for Clozapine-Treated Patients With Refractory Schizophrenia

Citation

Rocha, Fábio Lopes, and Cláudia Hara. "Benefits of Combining Aripiprazole to Clozapine: Three Case Reports." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 30, no. 6, 2006, pp. 1167-9.
Rocha FL, Hara C. Benefits of combining aripiprazole to clozapine: three case reports. Prog Neuropsychopharmacol Biol Psychiatry. 2006;30(6):1167-9.
Rocha, F. L., & Hara, C. (2006). Benefits of combining aripiprazole to clozapine: three case reports. Progress in Neuro-psychopharmacology & Biological Psychiatry, 30(6), 1167-9.
Rocha FL, Hara C. Benefits of Combining Aripiprazole to Clozapine: Three Case Reports. Prog Neuropsychopharmacol Biol Psychiatry. 2006 Aug 30;30(6):1167-9. PubMed PMID: 16647796.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Benefits of combining aripiprazole to clozapine: three case reports. AU - Rocha,Fábio Lopes, AU - Hara,Cláudia, Y1 - 2006/05/02/ PY - 2006/01/13/received PY - 2006/03/13/revised PY - 2006/03/14/accepted PY - 2006/5/2/pubmed PY - 2006/8/24/medline PY - 2006/5/2/entrez SP - 1167 EP - 9 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog Neuropsychopharmacol Biol Psychiatry VL - 30 IS - 6 N2 - OBJECTIVE: A substantial number of patients treated with clozapine shows insufficient response. The author presents the results of adding aripiprazole in patients resistant to clozapine. METHOD: Three cases of individuals with psychotic symptoms despite clozapine use and with significant side effects that were treated via this combination are presented. Response was evaluated by clinical assessment. RESULTS: Good clinical results were obtained in all three patients, with improvement of psychotic symptoms and of some of the side effects of clozapine. CONCLUSION: The findings from this case series suggest that adjunctive therapy with aripiprazole can be of benefit for treating clozapine resistant schizophrenic patients. SN - 0278-5846 UR - https://www.unboundmedicine.com/medline/citation/16647796/Benefits_of_combining_aripiprazole_to_clozapine:_three_case_reports_ DB - PRIME DP - Unbound Medicine ER -