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The effects of intravaginal clindamycin and metronidazole therapy on vaginal lactobacilli in patients with bacterial vaginosis.
Am J Obstet Gynecol. 2006 May; 194(5):1277-82.AJ

Abstract

OBJECTIVE

The purpose of this study was to determine the effects of 3 intravaginal antibacterial treatments on vaginal lactobacilli in patients with bacterial vaginosis (BV).

STUDY DESIGN

Retrospective analyses were performed on Lactobacillus scores from 3 similar studies evaluating 2 2% clindamycin vaginal creams and 0.75% metronidazole gel at baseline and at 21 to 30 days in 408 patients with BV. Scores were compared using a 1-way global F test and McNemar's test.

RESULTS

All groups had similar mean Lactobacillus scores at baseline (P = 0.37) and at 21 to 30 days (P = .71). The 3 groups were also comparable at both visits with respect to the distributions of scores within each group. In all groups, there was significant improvement in the percentages of patients with no lactobacilli present at 21 to 30 days compared with baseline (P < .0001 for all comparisons).

CONCLUSION

Clindamycin and metronidazole promoted similar levels of restoration of vaginal lactobacilli at 21 to 30 days.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Drexel University College of Medicine, Philadelphia, PA 19102, USA. pnyirjes@drexelmed.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16647910

Citation

Nyirjesy, Paul, et al. "The Effects of Intravaginal Clindamycin and Metronidazole Therapy On Vaginal Lactobacilli in Patients With Bacterial Vaginosis." American Journal of Obstetrics and Gynecology, vol. 194, no. 5, 2006, pp. 1277-82.
Nyirjesy P, McIntosh MJ, Gattermeir DJ, et al. The effects of intravaginal clindamycin and metronidazole therapy on vaginal lactobacilli in patients with bacterial vaginosis. Am J Obstet Gynecol. 2006;194(5):1277-82.
Nyirjesy, P., McIntosh, M. J., Gattermeir, D. J., Schumacher, R. J., Steinmetz, J. I., & Joffrion, J. L. (2006). The effects of intravaginal clindamycin and metronidazole therapy on vaginal lactobacilli in patients with bacterial vaginosis. American Journal of Obstetrics and Gynecology, 194(5), 1277-82.
Nyirjesy P, et al. The Effects of Intravaginal Clindamycin and Metronidazole Therapy On Vaginal Lactobacilli in Patients With Bacterial Vaginosis. Am J Obstet Gynecol. 2006;194(5):1277-82. PubMed PMID: 16647910.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of intravaginal clindamycin and metronidazole therapy on vaginal lactobacilli in patients with bacterial vaginosis. AU - Nyirjesy,Paul, AU - McIntosh,Matthew J, AU - Gattermeir,David J, AU - Schumacher,Robert J, AU - Steinmetz,Jana I, AU - Joffrion,James L, Y1 - 2006/04/21/ PY - 2005/07/10/received PY - 2005/10/23/revised PY - 2005/11/04/accepted PY - 2006/5/2/pubmed PY - 2006/6/2/medline PY - 2006/5/2/entrez SP - 1277 EP - 82 JF - American journal of obstetrics and gynecology JO - Am J Obstet Gynecol VL - 194 IS - 5 N2 - OBJECTIVE: The purpose of this study was to determine the effects of 3 intravaginal antibacterial treatments on vaginal lactobacilli in patients with bacterial vaginosis (BV). STUDY DESIGN: Retrospective analyses were performed on Lactobacillus scores from 3 similar studies evaluating 2 2% clindamycin vaginal creams and 0.75% metronidazole gel at baseline and at 21 to 30 days in 408 patients with BV. Scores were compared using a 1-way global F test and McNemar's test. RESULTS: All groups had similar mean Lactobacillus scores at baseline (P = 0.37) and at 21 to 30 days (P = .71). The 3 groups were also comparable at both visits with respect to the distributions of scores within each group. In all groups, there was significant improvement in the percentages of patients with no lactobacilli present at 21 to 30 days compared with baseline (P < .0001 for all comparisons). CONCLUSION: Clindamycin and metronidazole promoted similar levels of restoration of vaginal lactobacilli at 21 to 30 days. SN - 1097-6868 UR - https://www.unboundmedicine.com/medline/citation/16647910/The_effects_of_intravaginal_clindamycin_and_metronidazole_therapy_on_vaginal_lactobacilli_in_patients_with_bacterial_vaginosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9378(05)02451-8 DB - PRIME DP - Unbound Medicine ER -