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Prenatal exposure to maternal genital and reproductive infections and adult schizophrenia.
Am J Psychiatry 2006; 163(5):927-9AJ

Abstract

OBJECTIVE

In this birth cohort study, the authors examined the relation between prenatal exposure to maternal genital/reproductive (G/R) infections and schizophrenia in offspring.

METHOD

The birth cohort consisted of 7,794 offspring of pregnancies with prospectively acquired data on maternal G/R infections from obstetric records. The authors diagnosed 71 cases of schizophrenia and other schizophrenia spectrum disorders in this cohort. The relationship between maternal G/R infections and schizophrenia risk was modeled.

RESULTS

Exposure to G/R infections during the periconceptional period was associated with a significantly increased risk of schizophrenia and other schizophrenia spectrum disorders, with adjustment for maternal race, education, age, and mental illness.

CONCLUSIONS

Maternal G/R infection during periconception appears to increase the risk of schizophrenia in offspring.

Authors+Show Affiliations

New York State Psychiatric Institute, Columbia University, New York, NY 10032, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16648337

Citation

Babulas, Vicki, et al. "Prenatal Exposure to Maternal Genital and Reproductive Infections and Adult Schizophrenia." The American Journal of Psychiatry, vol. 163, no. 5, 2006, pp. 927-9.
Babulas V, Factor-Litvak P, Goetz R, et al. Prenatal exposure to maternal genital and reproductive infections and adult schizophrenia. Am J Psychiatry. 2006;163(5):927-9.
Babulas, V., Factor-Litvak, P., Goetz, R., Schaefer, C. A., & Brown, A. S. (2006). Prenatal exposure to maternal genital and reproductive infections and adult schizophrenia. The American Journal of Psychiatry, 163(5), pp. 927-9.
Babulas V, et al. Prenatal Exposure to Maternal Genital and Reproductive Infections and Adult Schizophrenia. Am J Psychiatry. 2006;163(5):927-9. PubMed PMID: 16648337.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prenatal exposure to maternal genital and reproductive infections and adult schizophrenia. AU - Babulas,Vicki, AU - Factor-Litvak,Pam, AU - Goetz,Raymond, AU - Schaefer,Catherine A, AU - Brown,Alan S, PY - 2006/5/2/pubmed PY - 2006/6/13/medline PY - 2006/5/2/entrez SP - 927 EP - 9 JF - The American journal of psychiatry JO - Am J Psychiatry VL - 163 IS - 5 N2 - OBJECTIVE: In this birth cohort study, the authors examined the relation between prenatal exposure to maternal genital/reproductive (G/R) infections and schizophrenia in offspring. METHOD: The birth cohort consisted of 7,794 offspring of pregnancies with prospectively acquired data on maternal G/R infections from obstetric records. The authors diagnosed 71 cases of schizophrenia and other schizophrenia spectrum disorders in this cohort. The relationship between maternal G/R infections and schizophrenia risk was modeled. RESULTS: Exposure to G/R infections during the periconceptional period was associated with a significantly increased risk of schizophrenia and other schizophrenia spectrum disorders, with adjustment for maternal race, education, age, and mental illness. CONCLUSIONS: Maternal G/R infection during periconception appears to increase the risk of schizophrenia in offspring. SN - 0002-953X UR - https://www.unboundmedicine.com/medline/citation/16648337/Prenatal_exposure_to_maternal_genital_and_reproductive_infections_and_adult_schizophrenia_ L2 - https://ajp.psychiatryonline.org/doi/full/10.1176/ajp.2006.163.5.927?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -