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Cancer-specific survival and predictors of prostate-specific antigen recurrence and survival in patients with seminal vesicle invasion after radical prostatectomy.
Cancer. 2006 Jun 01; 106(11):2369-75.C

Abstract

BACKGROUND

The objectives of the current study were to determine the long-term biochemical recurrence (BCR) and cancer-specific survival (CSS) rates for men with seminal vesicle invasion (SVI) and to identify risk factors for freedom from BCR and CSS in patients who received treatment in the prostate-specific antigen era and who had SVI identified at the time of radical prostatectomy (RP).

METHODS

Prospective clinical, pathologic, and outcome data were collected for 5377 men who underwent RP between June 1983 and August 2004. There were 936 patients who were excluded because they received treatment before RP. Multivariable analysis was used to identify the factors that predicted BCR and CSS.

RESULTS

Among 4441 eligible patients, 387 patients (8.7%) had SVI, and 91 of those 387 patients (24%) had lymph node involvement (LNI). In total, 210 patients experienced BCR. For patients without LNI, the 10-year and 15-year freedom from BCR rates were 36% and 32%, respectively, and the corresponding CSS rates were 89% and 81%, respectively. For the 91 men who had SVI and LNI, the 10-year BCR-free probability was 10%, but the 10-year CSS probability was 74%. By 10 years, patients with LNI were 3 times more likely to die from cancer than from other causes; nonetheless, 66% of patients were alive despite their advanced stage. The preoperative prostate-specific antigen level, extracapsular extension, LNI, and Gleason grade were associated independently with BCR. Gleason scores of 8 to 10 and LNI were significant predictors of CSS.

CONCLUSIONS

SVI does not invariably signal BCR or death from cancer in patients who undergo RP and pelvic lymph node dissection. Fifteen years later, approximately 33% of men with SVI and negative lymph nodes are expected remain free of BCR, and CSS was surprisingly good.

Authors+Show Affiliations

Secin FP
Department of Urology, Sidney Kimmel Center for Prostate and Urologic Cancers, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
Bianco FJ
No affiliation info available
Vickers AJ
No affiliation info available
Reuter V
No affiliation info available
Wheeler T
No affiliation info available
Fearn PA
No affiliation info available
Eastham JA
No affiliation info available
Scardino PT
No affiliation info available

MeSH

AgedDisease-Free SurvivalHumansMaleMiddle AgedNeoplasm InvasivenessNeoplasm Recurrence, LocalNeoplasm StagingPrognosisProstate-Specific AntigenProstatectomyProstatic NeoplasmsSeminal VesiclesSurvival Rate

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16649221

Citation

Secin, Fernando P., et al. "Cancer-specific Survival and Predictors of Prostate-specific Antigen Recurrence and Survival in Patients With Seminal Vesicle Invasion After Radical Prostatectomy." Cancer, vol. 106, no. 11, 2006, pp. 2369-75.
Secin FP, Bianco FJ, Vickers AJ, et al. Cancer-specific survival and predictors of prostate-specific antigen recurrence and survival in patients with seminal vesicle invasion after radical prostatectomy. Cancer. 2006;106(11):2369-75.
Secin, F. P., Bianco, F. J., Vickers, A. J., Reuter, V., Wheeler, T., Fearn, P. A., Eastham, J. A., & Scardino, P. T. (2006). Cancer-specific survival and predictors of prostate-specific antigen recurrence and survival in patients with seminal vesicle invasion after radical prostatectomy. Cancer, 106(11), 2369-75.
Secin FP, et al. Cancer-specific Survival and Predictors of Prostate-specific Antigen Recurrence and Survival in Patients With Seminal Vesicle Invasion After Radical Prostatectomy. Cancer. 2006 Jun 1;106(11):2369-75. PubMed PMID: 16649221.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cancer-specific survival and predictors of prostate-specific antigen recurrence and survival in patients with seminal vesicle invasion after radical prostatectomy. AU - Secin,Fernando P, AU - Bianco,Fernando J,Jr AU - Vickers,Andrew J, AU - Reuter,Victor, AU - Wheeler,Thomas, AU - Fearn,Paul A, AU - Eastham,James A, AU - Scardino,Peter T, PY - 2006/5/2/pubmed PY - 2006/7/13/medline PY - 2006/5/2/entrez SP - 2369 EP - 75 JF - Cancer JO - Cancer VL - 106 IS - 11 N2 - BACKGROUND: The objectives of the current study were to determine the long-term biochemical recurrence (BCR) and cancer-specific survival (CSS) rates for men with seminal vesicle invasion (SVI) and to identify risk factors for freedom from BCR and CSS in patients who received treatment in the prostate-specific antigen era and who had SVI identified at the time of radical prostatectomy (RP). METHODS: Prospective clinical, pathologic, and outcome data were collected for 5377 men who underwent RP between June 1983 and August 2004. There were 936 patients who were excluded because they received treatment before RP. Multivariable analysis was used to identify the factors that predicted BCR and CSS. RESULTS: Among 4441 eligible patients, 387 patients (8.7%) had SVI, and 91 of those 387 patients (24%) had lymph node involvement (LNI). In total, 210 patients experienced BCR. For patients without LNI, the 10-year and 15-year freedom from BCR rates were 36% and 32%, respectively, and the corresponding CSS rates were 89% and 81%, respectively. For the 91 men who had SVI and LNI, the 10-year BCR-free probability was 10%, but the 10-year CSS probability was 74%. By 10 years, patients with LNI were 3 times more likely to die from cancer than from other causes; nonetheless, 66% of patients were alive despite their advanced stage. The preoperative prostate-specific antigen level, extracapsular extension, LNI, and Gleason grade were associated independently with BCR. Gleason scores of 8 to 10 and LNI were significant predictors of CSS. CONCLUSIONS: SVI does not invariably signal BCR or death from cancer in patients who undergo RP and pelvic lymph node dissection. Fifteen years later, approximately 33% of men with SVI and negative lymph nodes are expected remain free of BCR, and CSS was surprisingly good. SN - 0008-543X UR - https://www.unboundmedicine.com/medline/citation/16649221/Cancer_specific_survival_and_predictors_of_prostate_specific_antigen_recurrence_and_survival_in_patients_with_seminal_vesicle_invasion_after_radical_prostatectomy_ DB - PRIME DP - Unbound Medicine ER -