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The prevalence of hypovitaminosis D and secondary hyperparathyroidism in obese Black Americans.
Clin Endocrinol (Oxf). 2006 May; 64(5):523-9.CE

Abstract

CONTEXT

Both obesity (body mass index, BMI > or = 30 kg/m2) and Black race are associated with a higher risk of vitamin D deficiency and secondary hyperparathyroidism. We hypothesized the risk of hypovitaminosis D would therefore be extraordinarily high in obese Black adults.

OBJECTIVE

To study the effects of race and adiposity on 25-hydroxyvitamin D [25(OH)D] and parathyroid hormone (iPTH).

DESIGN, SETTING AND PARTICIPANTS

Cross-sectional study of 379 Black and White adults from the Washington D.C. area. BMI ranged from 19.9 to 58.2 kg/m2.

MAIN OUTCOME MEASURES

Prevalence of hypovitaminosis D [25(OH)D < 37.5 nmol/l] and secondary hyperparathyroidism [25(OH)D < 37.5 nmol/l with iPTH > 4.2 pmol/l].

RESULTS

Obese Black subjects had lower mean 25(OH)D, 40.3 (SD, 20.3) nmol/l, compared with obese Whites, 64.5 (29.7), P < 0.001, nonobese Blacks, 53.3 (26.0), P = 0.0025 and nonobese Whites, 78.0 (33.5), P < 0.001. The prevalence of hypovitaminosis D increased with increasing BMI, and was greater (P < 0.001) in Blacks than Whites within all BMI categories examined. Among subjects with BMI > or = 35 kg/m2, 59% of Blacks vs 18% of Whites had hypovitaminosis D (odds ratio 6.5, 95% confidence interval 3.0-14.2). iPTH was negatively correlated with 25(OH)D (r = -0.31, P < 0.0001), suggesting those with hypovitaminosis D had clinically important vitamin D deficiency with secondary hyperparathyroidism. For secondary hyperparathyroidism 35.2% of Blacks met the criteria, compared to 9.7% of Whites (OR 3.6, CI 1.5-98.8).

CONCLUSIONS

Obese Black Americans are at particularly high risk for vitamin D deficiency and secondary hyperparathyroidism. Physicians should consider routinely supplementing such patients with vitamin D or screening them for hypovitaminosis D.

Authors+Show Affiliations

Unit on Growth and Obesity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-1103, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16649971

Citation

Yanoff, Lisa B., et al. "The Prevalence of Hypovitaminosis D and Secondary Hyperparathyroidism in Obese Black Americans." Clinical Endocrinology, vol. 64, no. 5, 2006, pp. 523-9.
Yanoff LB, Parikh SJ, Spitalnik A, et al. The prevalence of hypovitaminosis D and secondary hyperparathyroidism in obese Black Americans. Clin Endocrinol (Oxf). 2006;64(5):523-9.
Yanoff, L. B., Parikh, S. J., Spitalnik, A., Denkinger, B., Sebring, N. G., Slaughter, P., McHugh, T., Remaley, A. T., & Yanovski, J. A. (2006). The prevalence of hypovitaminosis D and secondary hyperparathyroidism in obese Black Americans. Clinical Endocrinology, 64(5), 523-9.
Yanoff LB, et al. The Prevalence of Hypovitaminosis D and Secondary Hyperparathyroidism in Obese Black Americans. Clin Endocrinol (Oxf). 2006;64(5):523-9. PubMed PMID: 16649971.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The prevalence of hypovitaminosis D and secondary hyperparathyroidism in obese Black Americans. AU - Yanoff,Lisa B, AU - Parikh,Shamik J, AU - Spitalnik,Amanda, AU - Denkinger,Blakeley, AU - Sebring,Nancy G, AU - Slaughter,Pamela, AU - McHugh,Theresa, AU - Remaley,Alan T, AU - Yanovski,Jack A, PY - 2006/5/3/pubmed PY - 2006/8/1/medline PY - 2006/5/3/entrez SP - 523 EP - 9 JF - Clinical endocrinology JO - Clin. Endocrinol. (Oxf) VL - 64 IS - 5 N2 - CONTEXT: Both obesity (body mass index, BMI > or = 30 kg/m2) and Black race are associated with a higher risk of vitamin D deficiency and secondary hyperparathyroidism. We hypothesized the risk of hypovitaminosis D would therefore be extraordinarily high in obese Black adults. OBJECTIVE: To study the effects of race and adiposity on 25-hydroxyvitamin D [25(OH)D] and parathyroid hormone (iPTH). DESIGN, SETTING AND PARTICIPANTS: Cross-sectional study of 379 Black and White adults from the Washington D.C. area. BMI ranged from 19.9 to 58.2 kg/m2. MAIN OUTCOME MEASURES: Prevalence of hypovitaminosis D [25(OH)D < 37.5 nmol/l] and secondary hyperparathyroidism [25(OH)D < 37.5 nmol/l with iPTH > 4.2 pmol/l]. RESULTS: Obese Black subjects had lower mean 25(OH)D, 40.3 (SD, 20.3) nmol/l, compared with obese Whites, 64.5 (29.7), P < 0.001, nonobese Blacks, 53.3 (26.0), P = 0.0025 and nonobese Whites, 78.0 (33.5), P < 0.001. The prevalence of hypovitaminosis D increased with increasing BMI, and was greater (P < 0.001) in Blacks than Whites within all BMI categories examined. Among subjects with BMI > or = 35 kg/m2, 59% of Blacks vs 18% of Whites had hypovitaminosis D (odds ratio 6.5, 95% confidence interval 3.0-14.2). iPTH was negatively correlated with 25(OH)D (r = -0.31, P < 0.0001), suggesting those with hypovitaminosis D had clinically important vitamin D deficiency with secondary hyperparathyroidism. For secondary hyperparathyroidism 35.2% of Blacks met the criteria, compared to 9.7% of Whites (OR 3.6, CI 1.5-98.8). CONCLUSIONS: Obese Black Americans are at particularly high risk for vitamin D deficiency and secondary hyperparathyroidism. Physicians should consider routinely supplementing such patients with vitamin D or screening them for hypovitaminosis D. SN - 0300-0664 UR - https://www.unboundmedicine.com/medline/citation/16649971/The_prevalence_of_hypovitaminosis_D_and_secondary_hyperparathyroidism_in_obese_Black_Americans_ L2 - https://doi.org/10.1111/j.1365-2265.2006.02502.x DB - PRIME DP - Unbound Medicine ER -