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Is the effect of probiotics on atopic dermatitis confined to food sensitized children?
Clin Exp Allergy. 2006 May; 36(5):629-33.CE

Abstract

BACKGROUND

Probiotics have previously been shown to reduce the severity of atopic dermatitis (AD) in infants and children.

OBJECTIVE

To examine the effect of two probiotics (Lactobacillus rhamnosus and Bifidobacteria lactis) on established AD in children.

SUBJECTS AND METHODS

Atopic children with current dermatitis received 2 x 10(10) colony forming units/g of probiotic (n=29) or placebo (n=30). Both were given daily as a powder mixed with food or water. SCORing Atopic Dermatitis (SCORAD; developed by the European Task Force on Atopic Dermatitis) a measure of the extent and severity of AD, was assessed at baseline, 2 and 12 weeks after starting treatment and 4 weeks after treatment was discontinued.

RESULTS

SCORAD geometric mean score at baseline was 26.0 (21.9-30.8) in the probiotic group and 35.1 (28.9-42.8) in the placebo group (P=0.02). After adjustment for these between-group baseline differences there was no significant improvement in AD at 12 weeks, SCORAD geometric mean ratio: 0.80 (95% confidence level (CI) 0.62-1.04, P=0.10). Among the food sensitized children, there was an improvement in those treated with probiotics, SCORAD geometric mean ratio: 0.73 (95% CI 0.54-1.00, P=0.047).

CONCLUSION

In this study a combination of Lactobacillus rhamnosus and Bifidobacteria lactis improved AD only in food sensitized children.

Authors+Show Affiliations

Wellington Asthma Research Group, Department of Medicine, School of Medicine and Health Sciences, Wellington, New Zealand.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16650048

Citation

Sistek, D, et al. "Is the Effect of Probiotics On Atopic Dermatitis Confined to Food Sensitized Children?" Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, vol. 36, no. 5, 2006, pp. 629-33.
Sistek D, Kelly R, Wickens K, et al. Is the effect of probiotics on atopic dermatitis confined to food sensitized children? Clin Exp Allergy. 2006;36(5):629-33.
Sistek, D., Kelly, R., Wickens, K., Stanley, T., Fitzharris, P., & Crane, J. (2006). Is the effect of probiotics on atopic dermatitis confined to food sensitized children? Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, 36(5), 629-33.
Sistek D, et al. Is the Effect of Probiotics On Atopic Dermatitis Confined to Food Sensitized Children. Clin Exp Allergy. 2006;36(5):629-33. PubMed PMID: 16650048.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is the effect of probiotics on atopic dermatitis confined to food sensitized children? AU - Sistek,D, AU - Kelly,R, AU - Wickens,K, AU - Stanley,T, AU - Fitzharris,P, AU - Crane,J, PY - 2006/5/3/pubmed PY - 2006/10/28/medline PY - 2006/5/3/entrez SP - 629 EP - 33 JF - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology JO - Clin. Exp. Allergy VL - 36 IS - 5 N2 - BACKGROUND: Probiotics have previously been shown to reduce the severity of atopic dermatitis (AD) in infants and children. OBJECTIVE: To examine the effect of two probiotics (Lactobacillus rhamnosus and Bifidobacteria lactis) on established AD in children. SUBJECTS AND METHODS: Atopic children with current dermatitis received 2 x 10(10) colony forming units/g of probiotic (n=29) or placebo (n=30). Both were given daily as a powder mixed with food or water. SCORing Atopic Dermatitis (SCORAD; developed by the European Task Force on Atopic Dermatitis) a measure of the extent and severity of AD, was assessed at baseline, 2 and 12 weeks after starting treatment and 4 weeks after treatment was discontinued. RESULTS: SCORAD geometric mean score at baseline was 26.0 (21.9-30.8) in the probiotic group and 35.1 (28.9-42.8) in the placebo group (P=0.02). After adjustment for these between-group baseline differences there was no significant improvement in AD at 12 weeks, SCORAD geometric mean ratio: 0.80 (95% confidence level (CI) 0.62-1.04, P=0.10). Among the food sensitized children, there was an improvement in those treated with probiotics, SCORAD geometric mean ratio: 0.73 (95% CI 0.54-1.00, P=0.047). CONCLUSION: In this study a combination of Lactobacillus rhamnosus and Bifidobacteria lactis improved AD only in food sensitized children. SN - 0954-7894 UR - https://www.unboundmedicine.com/medline/citation/16650048/Is_the_effect_of_probiotics_on_atopic_dermatitis_confined_to_food_sensitized_children L2 - https://doi.org/10.1111/j.1365-2222.2006.02485.x DB - PRIME DP - Unbound Medicine ER -