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Cutaneous phaeohyphomycosis caused by an Itraconazole and Amphoterecin B resistant strain of Veronaeae botryosa.
Int J Dermatol. 2006 Apr; 45(4):429-32.IJ

Abstract

BACKGROUND

Although the dematiaceous fungus Veronaea botryosa is rarely encountered clinically, it can be pathogenic.

METHODS

A patient with a history of diabetes mellitus, coronary artery disease, and Cushing's syndrome had recurrent multifocal, crusted, brownish-red noduloplaques on the right forearm, left upper limb, and right knee. A skin biopsy was obtained for histopathology and fungal cultures.

RESULTS

The histopathology showed brownish hyphae and yeast-like cells scattered in granulomatous infiltrates. Slide cultures revealed erect and straight conidiophores with two-celled cylindrical conidia, which have round tops and truncated bases. The fungus was identified as Veronaea botryosa. The disease slowly progressed despite a 6-month itraconazole regimen (200 mg daily). Subsequent use of Amphoterecin B produced only mild clinical improvements. Susceptibility tests showed resistance to both agents.

CONCLUSIONS

Cutaneous phaeohyphomycosis caused by V. botryosa is extremely rare. Antifungal susceptibility tests are important for choosing the appropriate drug and predicting the clinical outcome.

Authors+Show Affiliations

Chen YT
Department of Dermatology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
Lin HC
No affiliation info available
Huang CC
No affiliation info available
Lo YH
No affiliation info available

MeSH

AgedAmphotericin BAntifungal AgentsCoronary Artery DiseaseCushing SyndromeDermatomycosesDiabetes ComplicationsDrug Resistance, Multiple, FungalHumansItraconazoleMaleMitosporic Fungi

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

16650171

Citation

Chen, Yu-Ting, et al. "Cutaneous Phaeohyphomycosis Caused By an Itraconazole and Amphoterecin B Resistant Strain of Veronaeae Botryosa." International Journal of Dermatology, vol. 45, no. 4, 2006, pp. 429-32.
Chen YT, Lin HC, Huang CC, et al. Cutaneous phaeohyphomycosis caused by an Itraconazole and Amphoterecin B resistant strain of Veronaeae botryosa. Int J Dermatol. 2006;45(4):429-32.
Chen, Y. T., Lin, H. C., Huang, C. C., & Lo, Y. H. (2006). Cutaneous phaeohyphomycosis caused by an Itraconazole and Amphoterecin B resistant strain of Veronaeae botryosa. International Journal of Dermatology, 45(4), 429-32.
Chen YT, et al. Cutaneous Phaeohyphomycosis Caused By an Itraconazole and Amphoterecin B Resistant Strain of Veronaeae Botryosa. Int J Dermatol. 2006;45(4):429-32. PubMed PMID: 16650171.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cutaneous phaeohyphomycosis caused by an Itraconazole and Amphoterecin B resistant strain of Veronaeae botryosa. AU - Chen,Yu-Ting, AU - Lin,Hao-Chiung, AU - Huang,Chieh-Chen, AU - Lo,Yuan-Hsin, PY - 2006/5/3/pubmed PY - 2006/10/21/medline PY - 2006/5/3/entrez SP - 429 EP - 32 JF - International journal of dermatology JO - Int J Dermatol VL - 45 IS - 4 N2 - BACKGROUND: Although the dematiaceous fungus Veronaea botryosa is rarely encountered clinically, it can be pathogenic. METHODS: A patient with a history of diabetes mellitus, coronary artery disease, and Cushing's syndrome had recurrent multifocal, crusted, brownish-red noduloplaques on the right forearm, left upper limb, and right knee. A skin biopsy was obtained for histopathology and fungal cultures. RESULTS: The histopathology showed brownish hyphae and yeast-like cells scattered in granulomatous infiltrates. Slide cultures revealed erect and straight conidiophores with two-celled cylindrical conidia, which have round tops and truncated bases. The fungus was identified as Veronaea botryosa. The disease slowly progressed despite a 6-month itraconazole regimen (200 mg daily). Subsequent use of Amphoterecin B produced only mild clinical improvements. Susceptibility tests showed resistance to both agents. CONCLUSIONS: Cutaneous phaeohyphomycosis caused by V. botryosa is extremely rare. Antifungal susceptibility tests are important for choosing the appropriate drug and predicting the clinical outcome. SN - 0011-9059 UR - https://www.unboundmedicine.com/medline/citation/16650171/Cutaneous_phaeohyphomycosis_caused_by_an_Itraconazole_and_Amphoterecin_B_resistant_strain_of_Veronaeae_botryosa_ DB - PRIME DP - Unbound Medicine ER -