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Plasma metastin levels are negatively correlated with insulin resistance and free androgens in women with polycystic ovary syndrome.
Fertil Steril. 2006 Jun; 85(6):1778-83.FS

Abstract

OBJECTIVE

This study was designed to: [1] measure, for the first time, metastin (kisspeptin) levels in women with polycystic ovary syndrome (PCOS), a condition associated with hypersecretion of LH and hyperandrogenemia; and [2] investigate the possible correlations between metastin and PCOS-related reproductive and metabolic disturbances.

DESIGN

Clinical study.

SETTING

University hospital.

PATIENT(S)

Twenty-eight obese and overweight (body mass index [BMI] >25 kg/m2) women with PCOS, 28 normal weight (BMI <25 kg/m2) women with the syndrome, and 13 obese and overweight controls (ovulatory women without clinical or biochemical hyperandrogenemia) were selected.

INTERVENTION(S)

Blood samples were collected between day 3 and day 6 of a spontaneous bleeding episode in the PCOS groups and a menstrual cycle of the controls, at 9:00 AM, after an overnight fast.

MAIN OUTCOME MEASURE(S)

Circulating levels of LH, FSH, PRL, T, Delta4-androstenedione (A), DHEAS, 17alpha-OH-P, sex hormone-binding globulin (SHBG), insulin, glucose, and metastin were measured.

RESULT(S)

Both normal weight women with PCOS and obese controls were less insulin resistant and had significantly higher metastin levels, compared to obese and overweight women with the syndrome. Plasma kisspeptin levels were negatively correlated with BMI, free androgen index, and indices of insulin resistance.

CONCLUSION(S)

These results indicate that metastin is negatively associated with free androgen levels. The PCOS-associated insulin resistance and consequent hyperinsulinemia probably contribute to this effect by [1] stimulating androgen synthesis by the polycystic ovary (PCO) and [2] suppressing SHBG production in the liver.

Authors+Show Affiliations

Division of Endocrinology and Human Reproduction, Second Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16650418

Citation

Panidis, Dimitrios, et al. "Plasma Metastin Levels Are Negatively Correlated With Insulin Resistance and Free Androgens in Women With Polycystic Ovary Syndrome." Fertility and Sterility, vol. 85, no. 6, 2006, pp. 1778-83.
Panidis D, Rousso D, Koliakos G, et al. Plasma metastin levels are negatively correlated with insulin resistance and free androgens in women with polycystic ovary syndrome. Fertil Steril. 2006;85(6):1778-83.
Panidis, D., Rousso, D., Koliakos, G., Kourtis, A., Katsikis, I., Farmakiotis, D., Votsi, E., & Diamanti-Kandarakis, E. (2006). Plasma metastin levels are negatively correlated with insulin resistance and free androgens in women with polycystic ovary syndrome. Fertility and Sterility, 85(6), 1778-83.
Panidis D, et al. Plasma Metastin Levels Are Negatively Correlated With Insulin Resistance and Free Androgens in Women With Polycystic Ovary Syndrome. Fertil Steril. 2006;85(6):1778-83. PubMed PMID: 16650418.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma metastin levels are negatively correlated with insulin resistance and free androgens in women with polycystic ovary syndrome. AU - Panidis,Dimitrios, AU - Rousso,David, AU - Koliakos,George, AU - Kourtis,Anargyros, AU - Katsikis,Ilias, AU - Farmakiotis,Dimitrios, AU - Votsi,Elissavet, AU - Diamanti-Kandarakis,Evanthia, Y1 - 2006/05/02/ PY - 2005/03/24/received PY - 2005/11/06/revised PY - 2005/11/06/accepted PY - 2006/5/3/pubmed PY - 2006/6/28/medline PY - 2006/5/3/entrez SP - 1778 EP - 83 JF - Fertility and sterility JO - Fertil. Steril. VL - 85 IS - 6 N2 - OBJECTIVE: This study was designed to: [1] measure, for the first time, metastin (kisspeptin) levels in women with polycystic ovary syndrome (PCOS), a condition associated with hypersecretion of LH and hyperandrogenemia; and [2] investigate the possible correlations between metastin and PCOS-related reproductive and metabolic disturbances. DESIGN: Clinical study. SETTING: University hospital. PATIENT(S): Twenty-eight obese and overweight (body mass index [BMI] >25 kg/m2) women with PCOS, 28 normal weight (BMI <25 kg/m2) women with the syndrome, and 13 obese and overweight controls (ovulatory women without clinical or biochemical hyperandrogenemia) were selected. INTERVENTION(S): Blood samples were collected between day 3 and day 6 of a spontaneous bleeding episode in the PCOS groups and a menstrual cycle of the controls, at 9:00 AM, after an overnight fast. MAIN OUTCOME MEASURE(S): Circulating levels of LH, FSH, PRL, T, Delta4-androstenedione (A), DHEAS, 17alpha-OH-P, sex hormone-binding globulin (SHBG), insulin, glucose, and metastin were measured. RESULT(S): Both normal weight women with PCOS and obese controls were less insulin resistant and had significantly higher metastin levels, compared to obese and overweight women with the syndrome. Plasma kisspeptin levels were negatively correlated with BMI, free androgen index, and indices of insulin resistance. CONCLUSION(S): These results indicate that metastin is negatively associated with free androgen levels. The PCOS-associated insulin resistance and consequent hyperinsulinemia probably contribute to this effect by [1] stimulating androgen synthesis by the polycystic ovary (PCO) and [2] suppressing SHBG production in the liver. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/16650418/Plasma_metastin_levels_are_negatively_correlated_with_insulin_resistance_and_free_androgens_in_women_with_polycystic_ovary_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(06)00361-X DB - PRIME DP - Unbound Medicine ER -