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Objective cancer-related variables are not associated with depressive symptoms in women treated for early-stage breast cancer.
J Clin Oncol. 2006 Jun 01; 24(16):2420-7.JC

Abstract

PURPOSE

Women with breast cancer are thought to be vulnerable to depression for reasons associated with impact of diagnosis, treatment, and metabolic/endocrine changes. While the literature shows that most of these women do not become clinically depressed, 15% to 30% report elevated depressive symptoms that may be clinically important. The purpose was to identify and determine the relative importance of predictors of depressive symptoms in women treated for early-stage breast cancer.

PATIENTS AND METHODS

A total of 2,595 women (< or = 4 years following completion of initial treatment for early-stage breast cancer) provided data on cancer-related variables, personal characteristics, health behaviors, physical functioning/symptoms, and psychosocial variables. Participants were divided into high or low depressive groups using the Center for Epidemiologic Studies Depression Scale screening form.

RESULTS

Results of the binary logistic regression analysis were significant (overall R2 = 32.4%). Before entry of psychosocial variables, younger age, being unmarried, poorer physical functioning, and more vasomotor and gastrointestinal symptoms were significant risk factors for elevated depressive symptoms (R2 = 16.1%), but objective cancer-related variables were not. After inclusion of psychosocial variables in the model (DeltaR2 = 16.3%), none of the preceding variables remained significant. Greater risk for depressive symptoms was associated with stressful life events, less optimism, ambivalence over expressing negative emotions, sleep disturbance, and poorer social functioning.

CONCLUSION

Depressive symptoms in women treated for early-stage breast cancer are not associated with objective cancer-related factors. Rather, they are most strongly linked with many subjective psychosocial variables.

Authors+Show Affiliations

Department of Psychiatry, the Rebecca and John Moores University of California San Diego Cancer Center, La Jolla, CA 92093-0804, USA. wabardwell@ucsd.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16651649

Citation

Bardwell, Wayne A., et al. "Objective Cancer-related Variables Are Not Associated With Depressive Symptoms in Women Treated for Early-stage Breast Cancer." Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology, vol. 24, no. 16, 2006, pp. 2420-7.
Bardwell WA, Natarajan L, Dimsdale JE, et al. Objective cancer-related variables are not associated with depressive symptoms in women treated for early-stage breast cancer. J Clin Oncol. 2006;24(16):2420-7.
Bardwell, W. A., Natarajan, L., Dimsdale, J. E., Rock, C. L., Mortimer, J. E., Hollenbach, K., & Pierce, J. P. (2006). Objective cancer-related variables are not associated with depressive symptoms in women treated for early-stage breast cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology, 24(16), 2420-7.
Bardwell WA, et al. Objective Cancer-related Variables Are Not Associated With Depressive Symptoms in Women Treated for Early-stage Breast Cancer. J Clin Oncol. 2006 Jun 1;24(16):2420-7. PubMed PMID: 16651649.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Objective cancer-related variables are not associated with depressive symptoms in women treated for early-stage breast cancer. AU - Bardwell,Wayne A, AU - Natarajan,Loki, AU - Dimsdale,Joel E, AU - Rock,Cheryl L, AU - Mortimer,Joanne E, AU - Hollenbach,Kathy, AU - Pierce,John P, Y1 - 2006/05/01/ PY - 2006/5/3/pubmed PY - 2006/6/13/medline PY - 2006/5/3/entrez SP - 2420 EP - 7 JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology JO - J. Clin. Oncol. VL - 24 IS - 16 N2 - PURPOSE: Women with breast cancer are thought to be vulnerable to depression for reasons associated with impact of diagnosis, treatment, and metabolic/endocrine changes. While the literature shows that most of these women do not become clinically depressed, 15% to 30% report elevated depressive symptoms that may be clinically important. The purpose was to identify and determine the relative importance of predictors of depressive symptoms in women treated for early-stage breast cancer. PATIENTS AND METHODS: A total of 2,595 women (< or = 4 years following completion of initial treatment for early-stage breast cancer) provided data on cancer-related variables, personal characteristics, health behaviors, physical functioning/symptoms, and psychosocial variables. Participants were divided into high or low depressive groups using the Center for Epidemiologic Studies Depression Scale screening form. RESULTS: Results of the binary logistic regression analysis were significant (overall R2 = 32.4%). Before entry of psychosocial variables, younger age, being unmarried, poorer physical functioning, and more vasomotor and gastrointestinal symptoms were significant risk factors for elevated depressive symptoms (R2 = 16.1%), but objective cancer-related variables were not. After inclusion of psychosocial variables in the model (DeltaR2 = 16.3%), none of the preceding variables remained significant. Greater risk for depressive symptoms was associated with stressful life events, less optimism, ambivalence over expressing negative emotions, sleep disturbance, and poorer social functioning. CONCLUSION: Depressive symptoms in women treated for early-stage breast cancer are not associated with objective cancer-related factors. Rather, they are most strongly linked with many subjective psychosocial variables. SN - 1527-7755 UR - https://www.unboundmedicine.com/medline/citation/16651649/Objective_cancer_related_variables_are_not_associated_with_depressive_symptoms_in_women_treated_for_early_stage_breast_cancer_ L2 - http://ascopubs.org/doi/full/10.1200/JCO.2005.02.0081?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -