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Regional differences in abdominal fat loss.
Int J Obes (Lond). 2007 Jan; 31(1):147-52.IJ

Abstract

OBJECTIVE

This study determined if the magnetic resonance imaging (MRI) protocol used alters the estimation of change in abdominal fat with weight loss in obese type 2 diabetic women. This study also examined if there is a uniform fat loss across the abdomen.

METHODS AND PROCEDURES

Thirty-three obese postmenopausal women with type 2 diabetes (age 50-70 years, body mass index>30 kg/m(2)) had a total abdominal MRI scan pre- and post weight loss intervention. Three different MRI analysis protocols were used and compared: a single slice at L(2)-L(3) vs five slices (centered at L(4)-L(5)) vs all abdominal slices. In addition, the total abdominal scan was divided into four regions (four slices each) with region 3 (critical region) including the traditionally studied L(2)-L(3), and regions 1 and 2 superior and region 4 inferior to critical region 3. Analysis of variance (ANOVA) with repeated measures was used to compare the influence of weight loss on abdominal fat measured both regionally and using the varying number of MR slices.

RESULTS

At baseline, the ratio of visceral adipose tissue:subcutaneous adipose tissue (VAT:SAT) was significantly lower using the single-slice method compared to five slices and the total abdomen (P<0.01). Using the single-slice method, a lower %VAT was found than with the other methods (P<0.01). In regions 1, 2, 3, and 4, the absolute change in total fat was 122+/-50, 182+/-48, 182+/-55, and 155+/-40 cm(3), respectively. The regional difference in abdominal fat patterning revealed that the critical region (region 3) had a smaller VAT:SAT ratio than regions 1 and 2 (P<0.05), and the ratio at region 4 was smaller than region 3 (P<0.05). Weight loss resulted in a decrease in the VAT:SAT ratio (P<0.05) for regions 3 and 4 but not for regions 1 and 2.

CONCLUSIONS

The number of MR slices analyzed yields differential result in relative VAT distribution. Regional differences in abdominal fat loss occur with a greater relative VAT loss in the critical region, thus if only the critical region is analyzed the overall VAT loss induced by weight loss intervention may be overestimated.

Authors+Show Affiliations

Department of Exercise Science, Syracuse University, Syracuse, NY, USA. jakanale@syr.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16652124

Citation

Kanaley, J A., et al. "Regional Differences in Abdominal Fat Loss." International Journal of Obesity (2005), vol. 31, no. 1, 2007, pp. 147-52.
Kanaley JA, Giannopoulou I, Ploutz-Snyder LL. Regional differences in abdominal fat loss. Int J Obes (Lond). 2007;31(1):147-52.
Kanaley, J. A., Giannopoulou, I., & Ploutz-Snyder, L. L. (2007). Regional differences in abdominal fat loss. International Journal of Obesity (2005), 31(1), 147-52.
Kanaley JA, Giannopoulou I, Ploutz-Snyder LL. Regional Differences in Abdominal Fat Loss. Int J Obes (Lond). 2007;31(1):147-52. PubMed PMID: 16652124.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Regional differences in abdominal fat loss. AU - Kanaley,J A, AU - Giannopoulou,I, AU - Ploutz-Snyder,L L, Y1 - 2006/04/25/ PY - 2006/5/3/pubmed PY - 2007/3/16/medline PY - 2006/5/3/entrez SP - 147 EP - 52 JF - International journal of obesity (2005) JO - Int J Obes (Lond) VL - 31 IS - 1 N2 - OBJECTIVE: This study determined if the magnetic resonance imaging (MRI) protocol used alters the estimation of change in abdominal fat with weight loss in obese type 2 diabetic women. This study also examined if there is a uniform fat loss across the abdomen. METHODS AND PROCEDURES: Thirty-three obese postmenopausal women with type 2 diabetes (age 50-70 years, body mass index>30 kg/m(2)) had a total abdominal MRI scan pre- and post weight loss intervention. Three different MRI analysis protocols were used and compared: a single slice at L(2)-L(3) vs five slices (centered at L(4)-L(5)) vs all abdominal slices. In addition, the total abdominal scan was divided into four regions (four slices each) with region 3 (critical region) including the traditionally studied L(2)-L(3), and regions 1 and 2 superior and region 4 inferior to critical region 3. Analysis of variance (ANOVA) with repeated measures was used to compare the influence of weight loss on abdominal fat measured both regionally and using the varying number of MR slices. RESULTS: At baseline, the ratio of visceral adipose tissue:subcutaneous adipose tissue (VAT:SAT) was significantly lower using the single-slice method compared to five slices and the total abdomen (P<0.01). Using the single-slice method, a lower %VAT was found than with the other methods (P<0.01). In regions 1, 2, 3, and 4, the absolute change in total fat was 122+/-50, 182+/-48, 182+/-55, and 155+/-40 cm(3), respectively. The regional difference in abdominal fat patterning revealed that the critical region (region 3) had a smaller VAT:SAT ratio than regions 1 and 2 (P<0.05), and the ratio at region 4 was smaller than region 3 (P<0.05). Weight loss resulted in a decrease in the VAT:SAT ratio (P<0.05) for regions 3 and 4 but not for regions 1 and 2. CONCLUSIONS: The number of MR slices analyzed yields differential result in relative VAT distribution. Regional differences in abdominal fat loss occur with a greater relative VAT loss in the critical region, thus if only the critical region is analyzed the overall VAT loss induced by weight loss intervention may be overestimated. SN - 0307-0565 UR - https://www.unboundmedicine.com/medline/citation/16652124/Regional_differences_in_abdominal_fat_loss_ L2 - https://doi.org/10.1038/sj.ijo.0803359 DB - PRIME DP - Unbound Medicine ER -