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Molecular targets for the cancer preventive activity of tea polyphenols.
Mol Carcinog. 2006 Jun; 45(6):431-5.MC

Abstract

Inhibition of carcinogenesis by tea and tea polyphenols has been demonstrated in many animal models. The mechanisms of action have been extensively investigated mostly in cell culture systems with (-)-epigallocatechin-3-gallate (EGCG), the most active and major polyphenolic compound from green tea. However, the mechanisms of cancer preventive activity by tea and tea polyphenols are not clearly understood. This article discusses some of the reported mechanisms and possible targets for the action of EGCG. The difficulties and major issues in extrapolating data from studies in cancer cell lines to cancer prevention mechanisms are discussed. Activities observed in cell culture with high concentrations of EGCG may not be relevant because of the limited systemic bioavailability of EGCG. In addition, possible artifacts due to the auto-oxidation of EGCG may complicate this issue. Some recent studies revealed high-affinity EGCG binding proteins as possible direct targets for the action of EGCG. Validating the related cancer preventive mechanisms found in in vitro studies in animal models and human samples would be exciting.

Authors+Show Affiliations

Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

16652355

Citation

Yang, Chung S., et al. "Molecular Targets for the Cancer Preventive Activity of Tea Polyphenols." Molecular Carcinogenesis, vol. 45, no. 6, 2006, pp. 431-5.
Yang CS, Lambert JD, Hou Z, et al. Molecular targets for the cancer preventive activity of tea polyphenols. Mol Carcinog. 2006;45(6):431-5.
Yang, C. S., Lambert, J. D., Hou, Z., Ju, J., Lu, G., & Hao, X. (2006). Molecular targets for the cancer preventive activity of tea polyphenols. Molecular Carcinogenesis, 45(6), 431-5.
Yang CS, et al. Molecular Targets for the Cancer Preventive Activity of Tea Polyphenols. Mol Carcinog. 2006;45(6):431-5. PubMed PMID: 16652355.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Molecular targets for the cancer preventive activity of tea polyphenols. AU - Yang,Chung S, AU - Lambert,Joshua D, AU - Hou,Zhe, AU - Ju,Jihyeung, AU - Lu,Gang, AU - Hao,Xinpei, PY - 2006/5/3/pubmed PY - 2006/8/1/medline PY - 2006/5/3/entrez SP - 431 EP - 5 JF - Molecular carcinogenesis JO - Mol Carcinog VL - 45 IS - 6 N2 - Inhibition of carcinogenesis by tea and tea polyphenols has been demonstrated in many animal models. The mechanisms of action have been extensively investigated mostly in cell culture systems with (-)-epigallocatechin-3-gallate (EGCG), the most active and major polyphenolic compound from green tea. However, the mechanisms of cancer preventive activity by tea and tea polyphenols are not clearly understood. This article discusses some of the reported mechanisms and possible targets for the action of EGCG. The difficulties and major issues in extrapolating data from studies in cancer cell lines to cancer prevention mechanisms are discussed. Activities observed in cell culture with high concentrations of EGCG may not be relevant because of the limited systemic bioavailability of EGCG. In addition, possible artifacts due to the auto-oxidation of EGCG may complicate this issue. Some recent studies revealed high-affinity EGCG binding proteins as possible direct targets for the action of EGCG. Validating the related cancer preventive mechanisms found in in vitro studies in animal models and human samples would be exciting. SN - 0899-1987 UR - https://www.unboundmedicine.com/medline/citation/16652355/Molecular_targets_for_the_cancer_preventive_activity_of_tea_polyphenols_ L2 - https://doi.org/10.1002/mc.20228 DB - PRIME DP - Unbound Medicine ER -