Tags

Type your tag names separated by a space and hit enter

Cutting edge: CD1a+ antigen-presenting cells in human dermis respond rapidly to CCR7 ligands.
J Immunol. 2006 May 15; 176(10):5730-4.JI

Abstract

Recent data from murine models have confirmed that Langerhans cells are not the only population of APCs in the skin involved in initiating immune responses. In healthy human skin, we identify CD1a(+) dermal APCs located close to the lymphatic vessels in the upper layers of the dermis that are unequivocally distinct from migrating Langerhans cells but exhibit both potent allostimulatory capacity and a chemotactic response to CCR7 ligands. In contrast, CD14(+) dermal APCs are distributed throughout the dermis and lack a chemotactic response to CCR7 ligands. CD1a(+) dermal APCs therefore represent an APC population distinct from Langerhans cells that are capable of migrating to lymph nodes and stimulating naive T cells. In humans, CD1a(+) dermal APCs may fulfill some of the roles previously ascribed to Langerhans cells.

Authors+Show Affiliations

School of Biological Sciences, University of Auckland, 3a Symonds Street, Auckland, New Zealand.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16670277

Citation

Angel, Catherine E., et al. "Cutting Edge: CD1a+ Antigen-presenting Cells in Human Dermis Respond Rapidly to CCR7 Ligands." Journal of Immunology (Baltimore, Md. : 1950), vol. 176, no. 10, 2006, pp. 5730-4.
Angel CE, George E, Brooks AE, et al. Cutting edge: CD1a+ antigen-presenting cells in human dermis respond rapidly to CCR7 ligands. J Immunol. 2006;176(10):5730-4.
Angel, C. E., George, E., Brooks, A. E., Ostrovsky, L. L., Brown, T. L., & Dunbar, P. R. (2006). Cutting edge: CD1a+ antigen-presenting cells in human dermis respond rapidly to CCR7 ligands. Journal of Immunology (Baltimore, Md. : 1950), 176(10), 5730-4.
Angel CE, et al. Cutting Edge: CD1a+ Antigen-presenting Cells in Human Dermis Respond Rapidly to CCR7 Ligands. J Immunol. 2006 May 15;176(10):5730-4. PubMed PMID: 16670277.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cutting edge: CD1a+ antigen-presenting cells in human dermis respond rapidly to CCR7 ligands. AU - Angel,Catherine E, AU - George,Elizabeth, AU - Brooks,Anna E S, AU - Ostrovsky,Lena L, AU - Brown,Tim La H, AU - Dunbar,P Rod, PY - 2006/5/4/pubmed PY - 2006/6/23/medline PY - 2006/5/4/entrez SP - 5730 EP - 4 JF - Journal of immunology (Baltimore, Md. : 1950) JO - J Immunol VL - 176 IS - 10 N2 - Recent data from murine models have confirmed that Langerhans cells are not the only population of APCs in the skin involved in initiating immune responses. In healthy human skin, we identify CD1a(+) dermal APCs located close to the lymphatic vessels in the upper layers of the dermis that are unequivocally distinct from migrating Langerhans cells but exhibit both potent allostimulatory capacity and a chemotactic response to CCR7 ligands. In contrast, CD14(+) dermal APCs are distributed throughout the dermis and lack a chemotactic response to CCR7 ligands. CD1a(+) dermal APCs therefore represent an APC population distinct from Langerhans cells that are capable of migrating to lymph nodes and stimulating naive T cells. In humans, CD1a(+) dermal APCs may fulfill some of the roles previously ascribed to Langerhans cells. SN - 0022-1767 UR - https://www.unboundmedicine.com/medline/citation/16670277/Cutting_edge:_CD1a+_antigen_presenting_cells_in_human_dermis_respond_rapidly_to_CCR7_ligands_ L2 - http://www.jimmunol.org/cgi/pmidlookup?view=long&pmid=16670277 DB - PRIME DP - Unbound Medicine ER -