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Gastroesophageal reflux disease, colic and constipation in infants with food allergy.

Abstract

PURPOSE OF REVIEW

This review assesses the role of food allergy in the pathophysiology of gastroesophageal reflux disease, colic and constipation in infancy.

RECENT FINDINGS

Frequent regurgitation, persistent crying and constipation are common clinical problems in infancy. A subgroup of infants with these conditions may respond to hypoallergenic diets, but only few randomized clinical trials have been conducted. Skin prick testing and food-specific antibody levels are usually not elevated in these infants, whereas atopy patch testing may diagnostic. The mechanisms by which cow's milk and other food allergens induce gastrointestinal motility disorders are not understood. Apart from cell-mediated reactions, non-immunological effects of food constituents on gastrointestinal motility and gut microbiota may be involved in the pathogenesis. In the absence of reliable diagnostic tests, dietary elimination and re-challenge are usually required to confirm food allergy. A trial of amino acid-based formula or an oligoantigenic maternal elimination diet may be indicated in infants who have failed conventional medical treatment.

SUMMARY

Food allergy may contribute to gastroesophageal reflux disease, colic or constipation in infancy. Infants with these conditions often respond to hypoallergenic formula or a maternal elimination diet. Further research is needed to define the mechanisms and clinical markers of gastrointestinal food allergy in infancy.

Authors+Show Affiliations

Department of Allergy, Royal Children's Hospital, Parkville, Victoria, Australia. ralf.heine@rch.org.au

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16670518

Citation

Heine, Ralf G.. "Gastroesophageal Reflux Disease, Colic and Constipation in Infants With Food Allergy." Current Opinion in Allergy and Clinical Immunology, vol. 6, no. 3, 2006, pp. 220-5.
Heine RG. Gastroesophageal reflux disease, colic and constipation in infants with food allergy. Curr Opin Allergy Clin Immunol. 2006;6(3):220-5.
Heine, R. G. (2006). Gastroesophageal reflux disease, colic and constipation in infants with food allergy. Current Opinion in Allergy and Clinical Immunology, 6(3), pp. 220-5.
Heine RG. Gastroesophageal Reflux Disease, Colic and Constipation in Infants With Food Allergy. Curr Opin Allergy Clin Immunol. 2006;6(3):220-5. PubMed PMID: 16670518.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastroesophageal reflux disease, colic and constipation in infants with food allergy. A1 - Heine,Ralf G, PY - 2006/5/4/pubmed PY - 2006/7/6/medline PY - 2006/5/4/entrez SP - 220 EP - 5 JF - Current opinion in allergy and clinical immunology JO - Curr Opin Allergy Clin Immunol VL - 6 IS - 3 N2 - PURPOSE OF REVIEW: This review assesses the role of food allergy in the pathophysiology of gastroesophageal reflux disease, colic and constipation in infancy. RECENT FINDINGS: Frequent regurgitation, persistent crying and constipation are common clinical problems in infancy. A subgroup of infants with these conditions may respond to hypoallergenic diets, but only few randomized clinical trials have been conducted. Skin prick testing and food-specific antibody levels are usually not elevated in these infants, whereas atopy patch testing may diagnostic. The mechanisms by which cow's milk and other food allergens induce gastrointestinal motility disorders are not understood. Apart from cell-mediated reactions, non-immunological effects of food constituents on gastrointestinal motility and gut microbiota may be involved in the pathogenesis. In the absence of reliable diagnostic tests, dietary elimination and re-challenge are usually required to confirm food allergy. A trial of amino acid-based formula or an oligoantigenic maternal elimination diet may be indicated in infants who have failed conventional medical treatment. SUMMARY: Food allergy may contribute to gastroesophageal reflux disease, colic or constipation in infancy. Infants with these conditions often respond to hypoallergenic formula or a maternal elimination diet. Further research is needed to define the mechanisms and clinical markers of gastrointestinal food allergy in infancy. SN - 1528-4050 UR - https://www.unboundmedicine.com/medline/citation/16670518/Gastroesophageal_reflux_disease_colic_and_constipation_in_infants_with_food_allergy_ L2 - http://Insights.ovid.com/pubmed?pmid=16670518 DB - PRIME DP - Unbound Medicine ER -