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High-level Skp2 expression in pancreatic ductal adenocarcinoma: correlation with the extent of lymph node metastasis, higher histological grade, and poorer patient outcome.
Pancreas. 2006 May; 32(4):376-81.P

Abstract

OBJECTIVES

Recent studies have shown that overexpression of S-phase kinase-associated protein 2 (Skp2) occurs in many cancers at an advanced stage. We examined the clinicopathologic significance and prognostic implication of Skp2 expression in pancreatic invasive ductal carcinoma.

METHODS

Tissue samples from 46 pancreatic carcinomas were examined immunohistochemically for Skp2. The proportion of constituent tumor cells with Skp2 expression was analyzed and classified as high-level nuclear expression when more than 20% of the cancer cells were positive, or low-level nuclear expression otherwise.

RESULTS

High-level Skp2 overexpression was detected in 13 (28.3%) of the 46 tumors. The incidence of high-level Skp2 was correlated with higher histological grade (P = 0.0056), the extent of lymph node metastasis (P = 0.0086), the level of lymphatic permeation (P = 0.0024), and poorer patient outcome (P = 0.0189). Multivariate analysis showed that high-level Skp2 expression was an independent predictor of overall patient survival (P = 0.0140).

CONCLUSIONS

It is suggested that examination of Skp2 expression might be clinically useful for prognostication in patients with pancreatic carcinoma and that Skp2 protein might be a novel therapeutic molecular target.

Authors+Show Affiliations

Department of Surgery I, National Defense Medical College, Tokorozawa, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16670630

Citation

Einama, Takahiro, et al. "High-level Skp2 Expression in Pancreatic Ductal Adenocarcinoma: Correlation With the Extent of Lymph Node Metastasis, Higher Histological Grade, and Poorer Patient Outcome." Pancreas, vol. 32, no. 4, 2006, pp. 376-81.
Einama T, Kagata Y, Tsuda H, et al. High-level Skp2 expression in pancreatic ductal adenocarcinoma: correlation with the extent of lymph node metastasis, higher histological grade, and poorer patient outcome. Pancreas. 2006;32(4):376-81.
Einama, T., Kagata, Y., Tsuda, H., Morita, D., Ogata, S., Ueda, S., Takigawa, T., Kawarabayashi, N., Fukatsu, K., Sugiura, Y., Matsubara, O., & Hatsuse, K. (2006). High-level Skp2 expression in pancreatic ductal adenocarcinoma: correlation with the extent of lymph node metastasis, higher histological grade, and poorer patient outcome. Pancreas, 32(4), 376-81.
Einama T, et al. High-level Skp2 Expression in Pancreatic Ductal Adenocarcinoma: Correlation With the Extent of Lymph Node Metastasis, Higher Histological Grade, and Poorer Patient Outcome. Pancreas. 2006;32(4):376-81. PubMed PMID: 16670630.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High-level Skp2 expression in pancreatic ductal adenocarcinoma: correlation with the extent of lymph node metastasis, higher histological grade, and poorer patient outcome. AU - Einama,Takahiro, AU - Kagata,Yutaka, AU - Tsuda,Hitoshi, AU - Morita,Daisaku, AU - Ogata,Sho, AU - Ueda,Shigeto, AU - Takigawa,Toshimichi, AU - Kawarabayashi,Nobuaki, AU - Fukatsu,Kazuhiko, AU - Sugiura,Yoshiaki, AU - Matsubara,Osamu, AU - Hatsuse,Kazuo, PY - 2006/5/4/pubmed PY - 2006/5/26/medline PY - 2006/5/4/entrez SP - 376 EP - 81 JF - Pancreas JO - Pancreas VL - 32 IS - 4 N2 - OBJECTIVES: Recent studies have shown that overexpression of S-phase kinase-associated protein 2 (Skp2) occurs in many cancers at an advanced stage. We examined the clinicopathologic significance and prognostic implication of Skp2 expression in pancreatic invasive ductal carcinoma. METHODS: Tissue samples from 46 pancreatic carcinomas were examined immunohistochemically for Skp2. The proportion of constituent tumor cells with Skp2 expression was analyzed and classified as high-level nuclear expression when more than 20% of the cancer cells were positive, or low-level nuclear expression otherwise. RESULTS: High-level Skp2 overexpression was detected in 13 (28.3%) of the 46 tumors. The incidence of high-level Skp2 was correlated with higher histological grade (P = 0.0056), the extent of lymph node metastasis (P = 0.0086), the level of lymphatic permeation (P = 0.0024), and poorer patient outcome (P = 0.0189). Multivariate analysis showed that high-level Skp2 expression was an independent predictor of overall patient survival (P = 0.0140). CONCLUSIONS: It is suggested that examination of Skp2 expression might be clinically useful for prognostication in patients with pancreatic carcinoma and that Skp2 protein might be a novel therapeutic molecular target. SN - 1536-4828 UR - https://www.unboundmedicine.com/medline/citation/16670630/High_level_Skp2_expression_in_pancreatic_ductal_adenocarcinoma:_correlation_with_the_extent_of_lymph_node_metastasis_higher_histological_grade_and_poorer_patient_outcome_ L2 - https://doi.org/10.1097/01.mpa.0000220862.78248.c4 DB - PRIME DP - Unbound Medicine ER -