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Oxidative renal tubular injuries induced by aminocarboxylate-type iron (III) coordination compounds as candidate renal carcinogens.
Biometals. 2006 Dec; 19(6):675-83.B

Abstract

Oxidative renal tubular injuries and carcinogenesis induced by Fe(III)-nitrilotriacetate (NTA) and Fe(III)-ethylenediamine-N,N'-diacetate (EDDA) have been reported in rodent kidneys, but the identity of iron coordination structure essential for renal carcinogenesis, remains to be clarified. We compared renal tubular injuries caused by various low molecular weight aminocarboxylate type chelators with injuries due to NTA and EDDA. We found that Fe(III)-iminodiacetate (IDA), a novel iron-chelator, induced acute tubular injuries and lipid peroxidation to the same extent. We also prepared Fe(III)-IDA solutions at different pHs, and studied resultant oxidative injuries and physicochemical properties. The use of Fe(III)-IDA at pH 5.2, 6.2, and 7.2 resulted in renal tubular necrosis and apoptotic cell death, but neither tubular necrosis nor apoptosis was observed at pH 8.2. Spectrophotometric data suggested that Fe(III)-IDA had the same dimer structure from pH 6.2 to 7.2 as Fe(III)-NTA; but at a higher pH, iron polymerized and formed clusters. Fe(III)-IDA was crystallized, and this was confirmed by X-ray analysis and magnetic susceptibility measurements. These data indicated that Fe(III)-IDA possessed a linear mu-oxo bridged dinuclear iron (III) around neutral pH.

Authors+Show Affiliations

Department of Pathological Research, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama 700-8558, Japan. mzn@bronze.ocn.ne.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16670936

Citation

Mizuno, Ryuichiro, et al. "Oxidative Renal Tubular Injuries Induced By Aminocarboxylate-type Iron (III) Coordination Compounds as Candidate Renal Carcinogens." Biometals : an International Journal On the Role of Metal Ions in Biology, Biochemistry, and Medicine, vol. 19, no. 6, 2006, pp. 675-83.
Mizuno R, Kawabata T, Sutoh Y, et al. Oxidative renal tubular injuries induced by aminocarboxylate-type iron (III) coordination compounds as candidate renal carcinogens. Biometals. 2006;19(6):675-83.
Mizuno, R., Kawabata, T., Sutoh, Y., Nishida, Y., & Okada, S. (2006). Oxidative renal tubular injuries induced by aminocarboxylate-type iron (III) coordination compounds as candidate renal carcinogens. Biometals : an International Journal On the Role of Metal Ions in Biology, Biochemistry, and Medicine, 19(6), 675-83.
Mizuno R, et al. Oxidative Renal Tubular Injuries Induced By Aminocarboxylate-type Iron (III) Coordination Compounds as Candidate Renal Carcinogens. Biometals. 2006;19(6):675-83. PubMed PMID: 16670936.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidative renal tubular injuries induced by aminocarboxylate-type iron (III) coordination compounds as candidate renal carcinogens. AU - Mizuno,Ryuichiro, AU - Kawabata,Teruyuki, AU - Sutoh,Yuichi, AU - Nishida,Yuzo, AU - Okada,Shigeru, Y1 - 2006/05/03/ PY - 2005/09/07/received PY - 2006/03/10/accepted PY - 2006/5/4/pubmed PY - 2007/2/27/medline PY - 2006/5/4/entrez SP - 675 EP - 83 JF - Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine JO - Biometals VL - 19 IS - 6 N2 - Oxidative renal tubular injuries and carcinogenesis induced by Fe(III)-nitrilotriacetate (NTA) and Fe(III)-ethylenediamine-N,N'-diacetate (EDDA) have been reported in rodent kidneys, but the identity of iron coordination structure essential for renal carcinogenesis, remains to be clarified. We compared renal tubular injuries caused by various low molecular weight aminocarboxylate type chelators with injuries due to NTA and EDDA. We found that Fe(III)-iminodiacetate (IDA), a novel iron-chelator, induced acute tubular injuries and lipid peroxidation to the same extent. We also prepared Fe(III)-IDA solutions at different pHs, and studied resultant oxidative injuries and physicochemical properties. The use of Fe(III)-IDA at pH 5.2, 6.2, and 7.2 resulted in renal tubular necrosis and apoptotic cell death, but neither tubular necrosis nor apoptosis was observed at pH 8.2. Spectrophotometric data suggested that Fe(III)-IDA had the same dimer structure from pH 6.2 to 7.2 as Fe(III)-NTA; but at a higher pH, iron polymerized and formed clusters. Fe(III)-IDA was crystallized, and this was confirmed by X-ray analysis and magnetic susceptibility measurements. These data indicated that Fe(III)-IDA possessed a linear mu-oxo bridged dinuclear iron (III) around neutral pH. SN - 0966-0844 UR - https://www.unboundmedicine.com/medline/citation/16670936/Oxidative_renal_tubular_injuries_induced_by_aminocarboxylate_type_iron__III__coordination_compounds_as_candidate_renal_carcinogens_ L2 - https://doi.org/10.1007/s10534-006-9004-4 DB - PRIME DP - Unbound Medicine ER -