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Palladium asymmetric allylic alkylation of prochiral nucleophiles: horsfiline.
Org Lett. 2006 May 11; 8(10):2027-30.OL

Abstract

[reaction; see text] The asymmetric synthesis of the oxindole alkaloid horsfiline is described. A palladium-catalyzed asymmetric allylic alkylation (AAA) is used to set the spiro(pyrrolidine-oxindole) stereogenic center.

Links

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Authors+Show Affiliations

Trost BM
Department of Chemistry, Stanford University, California 94305, USA. bmtrost@stanford.edu
Brennan MK
No affiliation info available

MeSH

AlkaloidsAlkylationCatalysisIndolesMolecular StructurePalladiumSpiro CompoundsStereoisomerism

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

16671773

Citation

Trost, Barry M., and Megan K. Brennan. "Palladium Asymmetric Allylic Alkylation of Prochiral Nucleophiles: Horsfiline." Organic Letters, vol. 8, no. 10, 2006, pp. 2027-30.
Trost BM, Brennan MK. Palladium asymmetric allylic alkylation of prochiral nucleophiles: horsfiline. Org Lett. 2006;8(10):2027-30.
Trost, B. M., & Brennan, M. K. (2006). Palladium asymmetric allylic alkylation of prochiral nucleophiles: horsfiline. Organic Letters, 8(10), 2027-30.
Trost BM, Brennan MK. Palladium Asymmetric Allylic Alkylation of Prochiral Nucleophiles: Horsfiline. Org Lett. 2006 May 11;8(10):2027-30. PubMed PMID: 16671773.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Palladium asymmetric allylic alkylation of prochiral nucleophiles: horsfiline. AU - Trost,Barry M, AU - Brennan,Megan K, PY - 2006/5/5/pubmed PY - 2007/2/16/medline PY - 2006/5/5/entrez SP - 2027 EP - 30 JF - Organic letters JO - Org Lett VL - 8 IS - 10 N2 - [reaction; see text] The asymmetric synthesis of the oxindole alkaloid horsfiline is described. A palladium-catalyzed asymmetric allylic alkylation (AAA) is used to set the spiro(pyrrolidine-oxindole) stereogenic center. SN - 1523-7060 UR - https://www.unboundmedicine.com/medline/citation/16671773/Palladium_asymmetric_allylic_alkylation_of_prochiral_nucleophiles:_horsfiline_ DB - PRIME DP - Unbound Medicine ER -