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Feasibility of closed-loop titration of propofol guided by the Bispectral Index for general anaesthesia induction: a prospective randomized study.
Eur J Anaesthesiol. 2006 Jun; 23(6):465-9.EJ

Abstract

BACKGROUND

This study was designed to evaluate the feasibility of propofol infusion by a closed-loop system for the titration of anaesthetic induction guided by Bispectral Index.

METHODS

Forty patients were prospectively and randomly allocated into two groups: the target control infusion (TCI) group, where propofol titration was performed manually guided by the Bispectral Index using a commercial pharmacokinetic model (Diprifusor device) and the closed-loop group where titration was performed using a proportional differential algorithm. For both groups, the objective was to achieve a Bispectral Index of 50. Remifentanil TCI was infused at a target of 2 ng mL-1 and was maintained constant throughout the study. Feasibility of automatic induction was evaluated with performance error and haemodynamic data.

RESULTS

Bispectral Index overshoot (-9 +/- 13% vs. -16 +/- 20%, P = 0.035) and mean duration of induction (381 +/- 106 s vs. 490 +/- 131 s, P = 0.004) were lower in the closed-loop group than in the TCI group. Haemodynamic data were similar between groups with a similar use of ephedrine bolus.

CONCLUSION

The system was able to allow induction clinically for all patients. Automated titration guided by Bispectral Index for propofol infusion was feasible without increase in haemodynamic adverse effects.

Authors+Show Affiliations

Department of Anaesthesiology, Hôpital Foch, Suresnes, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16672092

Citation

Liu, N, et al. "Feasibility of Closed-loop Titration of Propofol Guided By the Bispectral Index for General Anaesthesia Induction: a Prospective Randomized Study." European Journal of Anaesthesiology, vol. 23, no. 6, 2006, pp. 465-9.
Liu N, Chazot T, Trillat B, et al. Feasibility of closed-loop titration of propofol guided by the Bispectral Index for general anaesthesia induction: a prospective randomized study. Eur J Anaesthesiol. 2006;23(6):465-9.
Liu, N., Chazot, T., Trillat, B., Pirracchio, R., Law-Koune, J. D., Barvais, L., & Fischler, M. (2006). Feasibility of closed-loop titration of propofol guided by the Bispectral Index for general anaesthesia induction: a prospective randomized study. European Journal of Anaesthesiology, 23(6), 465-9.
Liu N, et al. Feasibility of Closed-loop Titration of Propofol Guided By the Bispectral Index for General Anaesthesia Induction: a Prospective Randomized Study. Eur J Anaesthesiol. 2006;23(6):465-9. PubMed PMID: 16672092.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Feasibility of closed-loop titration of propofol guided by the Bispectral Index for general anaesthesia induction: a prospective randomized study. AU - Liu,N, AU - Chazot,T, AU - Trillat,B, AU - Pirracchio,R, AU - Law-Koune,J-D, AU - Barvais,L, AU - Fischler,M, PY - 2006/01/12/accepted PY - 2006/5/5/pubmed PY - 2006/12/9/medline PY - 2006/5/5/entrez SP - 465 EP - 9 JF - European journal of anaesthesiology JO - Eur J Anaesthesiol VL - 23 IS - 6 N2 - BACKGROUND: This study was designed to evaluate the feasibility of propofol infusion by a closed-loop system for the titration of anaesthetic induction guided by Bispectral Index. METHODS: Forty patients were prospectively and randomly allocated into two groups: the target control infusion (TCI) group, where propofol titration was performed manually guided by the Bispectral Index using a commercial pharmacokinetic model (Diprifusor device) and the closed-loop group where titration was performed using a proportional differential algorithm. For both groups, the objective was to achieve a Bispectral Index of 50. Remifentanil TCI was infused at a target of 2 ng mL-1 and was maintained constant throughout the study. Feasibility of automatic induction was evaluated with performance error and haemodynamic data. RESULTS: Bispectral Index overshoot (-9 +/- 13% vs. -16 +/- 20%, P = 0.035) and mean duration of induction (381 +/- 106 s vs. 490 +/- 131 s, P = 0.004) were lower in the closed-loop group than in the TCI group. Haemodynamic data were similar between groups with a similar use of ephedrine bolus. CONCLUSION: The system was able to allow induction clinically for all patients. Automated titration guided by Bispectral Index for propofol infusion was feasible without increase in haemodynamic adverse effects. SN - 0265-0215 UR - https://www.unboundmedicine.com/medline/citation/16672092/Feasibility_of_closed_loop_titration_of_propofol_guided_by_the_Bispectral_Index_for_general_anaesthesia_induction:_a_prospective_randomized_study_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=16672092.ui DB - PRIME DP - Unbound Medicine ER -