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Toward a better understanding of Klotho.
Sci Aging Knowledge Environ. 2006 May 03; 2006(8):pe11.SA

Abstract

klotho mutant mice were originally described as a short-lived mouse model with premature aging-like disorders. The klotho gene responsible for these phenotypes encodes a type I membrane protein with a considerable similarity to beta-glycosidase. klotho is predominantly expressed in tissues functioning in the regulation of calcium homeostasis. Suggested functions of Klotho are (i) a fundamental regulator of calcium homeostasis, namely, a cofactor for the fibroblast growth factor (FGF) receptor 1c in FGF23 signaling and a regulator of parathyroid hormone secretion; (ii) a hormone that interferes with the intracellular signaling of insulin and insulin-like growth factor-1; and (iii) a beta-glucuronidase that activates the transient receptor potential ion channel TRPV5 by trimming its sugar moiety. How can we reconcile these pleiotropic functions of Klotho? Is there any common mechanism? Further in vivo studies, and biochemical as well as physiological analyses, are required for a better understanding of the molecular aspects of Klotho.

Authors+Show Affiliations

Department of Pathology and Tumor Biology, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan. nabemr@lmls.med.kyoto-u.ac.jp

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16672727

Citation

Nabeshima, Yo-ichi. "Toward a Better Understanding of Klotho." Science of Aging Knowledge Environment : SAGE KE, vol. 2006, no. 8, 2006, pp. pe11.
Nabeshima Y. Toward a better understanding of Klotho. Sci Aging Knowledge Environ. 2006;2006(8):pe11.
Nabeshima, Y. (2006). Toward a better understanding of Klotho. Science of Aging Knowledge Environment : SAGE KE, 2006(8), pe11.
Nabeshima Y. Toward a Better Understanding of Klotho. Sci Aging Knowledge Environ. 2006 May 3;2006(8):pe11. PubMed PMID: 16672727.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Toward a better understanding of Klotho. A1 - Nabeshima,Yo-ichi, Y1 - 2006/05/03/ PY - 2006/5/5/pubmed PY - 2006/6/6/medline PY - 2006/5/5/entrez SP - pe11 EP - pe11 JF - Science of aging knowledge environment : SAGE KE JO - Sci Aging Knowledge Environ VL - 2006 IS - 8 N2 - klotho mutant mice were originally described as a short-lived mouse model with premature aging-like disorders. The klotho gene responsible for these phenotypes encodes a type I membrane protein with a considerable similarity to beta-glycosidase. klotho is predominantly expressed in tissues functioning in the regulation of calcium homeostasis. Suggested functions of Klotho are (i) a fundamental regulator of calcium homeostasis, namely, a cofactor for the fibroblast growth factor (FGF) receptor 1c in FGF23 signaling and a regulator of parathyroid hormone secretion; (ii) a hormone that interferes with the intracellular signaling of insulin and insulin-like growth factor-1; and (iii) a beta-glucuronidase that activates the transient receptor potential ion channel TRPV5 by trimming its sugar moiety. How can we reconcile these pleiotropic functions of Klotho? Is there any common mechanism? Further in vivo studies, and biochemical as well as physiological analyses, are required for a better understanding of the molecular aspects of Klotho. SN - 1539-6150 UR - https://www.unboundmedicine.com/medline/citation/16672727/Toward_a_better_understanding_of_Klotho_ L2 - http://sageke.sciencemag.org/cgi/pmidlookup?view=long&pmid=16672727 DB - PRIME DP - Unbound Medicine ER -