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Adiponectin and resistin in PCOS: a clinical, biochemical and molecular genetic study.
Hum Reprod 2006; 21(9):2257-65HR

Abstract

BACKGROUND

We conducted a cross-sectional case-control study to evaluate the possible involvement of adiponectin and resistin in the pathogenesis of polycystic ovary syndrome (PCOS).

METHODS

Seventy-six PCOS patients and 40 non-hyperandrogenic women matched for BMI and degree of obesity were included. Serum adiponectin and resistin levels, anthropometrical and hormonal variables, the 45 T-->G and 276 G-->T polymorphisms in the adiponectin gene, and the -420 C-->G variant in the resistin gene, were analysed.

RESULTS

Serum adiponectin concentrations were reduced in PCOS patients compared with controls (P = 0.038) irrespective of the degree of obesity, whereas serum resistin levels were increased in overweight and obese women compared with lean subjects (P = 0.016), irrespective of their PCOS or controls status. The adiponectin and resistin polymorphisms were not associated with PCOS and did not influence serum levels of adiponectin, resistin and other clinical and hormonal variables. In a multiple regression model, the waist-to-hip ratio, free testosterone levels and age, but not insulin resistance, were the major determinants of hypoadiponectinaemia.

CONCLUSIONS

PCOS patients present with hypoadiponectinaemia, in relation with abdominal adiposity and hyperandrogenism. Our present results suggest that hyperandrogenism and abdominal obesity, by reducing the serum levels of the insulin sensitizer adipokine adiponectin, might contribute to the insulin resistance of PCOS.

Authors+Show Affiliations

Department of Endocrinology, Hospital Universitario Ramón y Cajal, Madrid, Spain. hescobarm.hrc@salud.madrid.org

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16675483

Citation

Escobar-Morreale, H F., et al. "Adiponectin and Resistin in PCOS: a Clinical, Biochemical and Molecular Genetic Study." Human Reproduction (Oxford, England), vol. 21, no. 9, 2006, pp. 2257-65.
Escobar-Morreale HF, Villuendas G, Botella-Carretero JI, et al. Adiponectin and resistin in PCOS: a clinical, biochemical and molecular genetic study. Hum Reprod. 2006;21(9):2257-65.
Escobar-Morreale, H. F., Villuendas, G., Botella-Carretero, J. I., Alvarez-Blasco, F., Sanchón, R., Luque-Ramírez, M., & San Millán, J. L. (2006). Adiponectin and resistin in PCOS: a clinical, biochemical and molecular genetic study. Human Reproduction (Oxford, England), 21(9), pp. 2257-65.
Escobar-Morreale HF, et al. Adiponectin and Resistin in PCOS: a Clinical, Biochemical and Molecular Genetic Study. Hum Reprod. 2006;21(9):2257-65. PubMed PMID: 16675483.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adiponectin and resistin in PCOS: a clinical, biochemical and molecular genetic study. AU - Escobar-Morreale,H F, AU - Villuendas,G, AU - Botella-Carretero,J I, AU - Alvarez-Blasco,F, AU - Sanchón,R, AU - Luque-Ramírez,M, AU - San Millán,J L, Y1 - 2006/05/04/ PY - 2006/5/6/pubmed PY - 2007/1/31/medline PY - 2006/5/6/entrez SP - 2257 EP - 65 JF - Human reproduction (Oxford, England) JO - Hum. Reprod. VL - 21 IS - 9 N2 - BACKGROUND: We conducted a cross-sectional case-control study to evaluate the possible involvement of adiponectin and resistin in the pathogenesis of polycystic ovary syndrome (PCOS). METHODS: Seventy-six PCOS patients and 40 non-hyperandrogenic women matched for BMI and degree of obesity were included. Serum adiponectin and resistin levels, anthropometrical and hormonal variables, the 45 T-->G and 276 G-->T polymorphisms in the adiponectin gene, and the -420 C-->G variant in the resistin gene, were analysed. RESULTS: Serum adiponectin concentrations were reduced in PCOS patients compared with controls (P = 0.038) irrespective of the degree of obesity, whereas serum resistin levels were increased in overweight and obese women compared with lean subjects (P = 0.016), irrespective of their PCOS or controls status. The adiponectin and resistin polymorphisms were not associated with PCOS and did not influence serum levels of adiponectin, resistin and other clinical and hormonal variables. In a multiple regression model, the waist-to-hip ratio, free testosterone levels and age, but not insulin resistance, were the major determinants of hypoadiponectinaemia. CONCLUSIONS: PCOS patients present with hypoadiponectinaemia, in relation with abdominal adiposity and hyperandrogenism. Our present results suggest that hyperandrogenism and abdominal obesity, by reducing the serum levels of the insulin sensitizer adipokine adiponectin, might contribute to the insulin resistance of PCOS. SN - 0268-1161 UR - https://www.unboundmedicine.com/medline/citation/16675483/Adiponectin_and_resistin_in_PCOS:_a_clinical_biochemical_and_molecular_genetic_study_ L2 - https://academic.oup.com/humrep/article-lookup/doi/10.1093/humrep/del146 DB - PRIME DP - Unbound Medicine ER -