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Protection effect of piper betel leaf extract against carbon tetrachloride-induced liver fibrosis in rats.
Arch Toxicol 2007; 81(1):45-55AT

Abstract

Piper betel leaves (PBL) are used in Chinese folk medicine for the treatment of various disorders. PBL has the biological capabilities of detoxication, antioxidation, and antimutation. In this study, we evaluated the antihepatotoxic effect of PBL extract on the carbon tetrachloride (CCl(4))-induced liver injury in a rat model. Fibrosis and hepatic damage, as reveled by histology and the activities of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were induced in rats by an administration of CCl(4) (8%, 1 ml/kg body weight) thrice a week for 4 weeks. PBL extract significantly inhibited the elevated AST and ALT activities caused by CCl(4) intoxication. It also attenuated total glutathione S-transferase (GST) activity and GST alpha isoform activity, and on the other hand, enhanced superoxide dismutase (SOD) and catalase (CAT) activities. The histological examination showed the PBL extract protected liver from the damage induced by CCl(4) by decreasing alpha-smooth muscle actin (alpha-sma) expression, inducing active matrix metalloproteinase-2 (MMP2) expression though Ras/Erk pathway, and inhibiting TIMP2 level that consequently attenuated the fibrosis of liver. The data of this study support a chemopreventive potential of PBL against liver fibrosis.

Authors+Show Affiliations

Institute of Biochemistry and Biotechnology, Chung Shan Medical University, No. 110, Section 2, Chien Kauo N. Road, Taichung 402, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16676162

Citation

Young, Shun-Chieh, et al. "Protection Effect of Piper Betel Leaf Extract Against Carbon Tetrachloride-induced Liver Fibrosis in Rats." Archives of Toxicology, vol. 81, no. 1, 2007, pp. 45-55.
Young SC, Wang CJ, Lin JJ, et al. Protection effect of piper betel leaf extract against carbon tetrachloride-induced liver fibrosis in rats. Arch Toxicol. 2007;81(1):45-55.
Young, S. C., Wang, C. J., Lin, J. J., Peng, P. L., Hsu, J. L., & Chou, F. P. (2007). Protection effect of piper betel leaf extract against carbon tetrachloride-induced liver fibrosis in rats. Archives of Toxicology, 81(1), pp. 45-55.
Young SC, et al. Protection Effect of Piper Betel Leaf Extract Against Carbon Tetrachloride-induced Liver Fibrosis in Rats. Arch Toxicol. 2007;81(1):45-55. PubMed PMID: 16676162.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protection effect of piper betel leaf extract against carbon tetrachloride-induced liver fibrosis in rats. AU - Young,Shun-Chieh, AU - Wang,Chau-Jong, AU - Lin,Jing-Jing, AU - Peng,Pei-Ling, AU - Hsu,Jui-Ling, AU - Chou,Fen-Pi, Y1 - 2006/05/05/ PY - 2006/01/13/received PY - 2006/03/27/accepted PY - 2006/5/6/pubmed PY - 2007/10/25/medline PY - 2006/5/6/entrez SP - 45 EP - 55 JF - Archives of toxicology JO - Arch. Toxicol. VL - 81 IS - 1 N2 - Piper betel leaves (PBL) are used in Chinese folk medicine for the treatment of various disorders. PBL has the biological capabilities of detoxication, antioxidation, and antimutation. In this study, we evaluated the antihepatotoxic effect of PBL extract on the carbon tetrachloride (CCl(4))-induced liver injury in a rat model. Fibrosis and hepatic damage, as reveled by histology and the activities of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were induced in rats by an administration of CCl(4) (8%, 1 ml/kg body weight) thrice a week for 4 weeks. PBL extract significantly inhibited the elevated AST and ALT activities caused by CCl(4) intoxication. It also attenuated total glutathione S-transferase (GST) activity and GST alpha isoform activity, and on the other hand, enhanced superoxide dismutase (SOD) and catalase (CAT) activities. The histological examination showed the PBL extract protected liver from the damage induced by CCl(4) by decreasing alpha-smooth muscle actin (alpha-sma) expression, inducing active matrix metalloproteinase-2 (MMP2) expression though Ras/Erk pathway, and inhibiting TIMP2 level that consequently attenuated the fibrosis of liver. The data of this study support a chemopreventive potential of PBL against liver fibrosis. SN - 0340-5761 UR - https://www.unboundmedicine.com/medline/citation/16676162/Protection_effect_of_piper_betel_leaf_extract_against_carbon_tetrachloride_induced_liver_fibrosis_in_rats_ L2 - https://dx.doi.org/10.1007/s00204-006-0106-0 DB - PRIME DP - Unbound Medicine ER -