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[Vagal effects on inducibility of atrial fibrillation at different sites of pulmonary veins after autonomic denervation].
Zhonghua Yi Xue Za Zhi. 2006 Feb 07; 86(5):317-20.ZY

Abstract

OBJECTIVE

To investigate the vagal effects on the inducibility of atrial fibrillation (AF) at different sites of pulmonary vein after autonomic denervation.

METHODS

The bilateral cervical vagal trunks of 10 male mongrel dogs were isolated and decentralized. The ansae subclaviae were exposed, ligated, and cut. Needle electrodes were inserted into the subcutaneous tissue of the 4 extremities to record the myocardiogram. Right ventricle electrode was introduced via femoral vein and an electrode with 4 poles was sutured with the right appendage (RAA), left appendage (LAA), left atrium (LA), left superior pulmonary vein (LSPV), right superior pulmonary vein (RSPV), left inferior pulmonary vein (LIPV), and right inferior pulmonary vein (RIPV) respectively. Local burst stimulation (S1S1 = 80 ms, impulse duration = 0.5 ms) was performed on these sites to record the baseline AF inducibility. When sinus cardiac arrest for 2 s or complete atrio-ventricular block occurred programmed bilateral vagal nerves stimulation (VNS) was performed with the frequency of 12.5 Hz, impulse duration of 0.5 ms, and voltage of 5-8 V. Atropine 0.04 mg/kg was dripped intravenously. The changes of AV inducibility were observed.

RESULTS

In the baseline state, S1S1 programmed stimulation on all the sites evoked single or multiple atrial premature beats and short runs of atrial tachycardia, only a few sites induced AF. However, S1S1 programmed stimulation combined with VNS significantly increased the frequencies of induced AV at the sites of 4 PVs (P < 0.05, P < 0.01). When atropine was dripped the AV induction rates at all sites did not changed significantly (all P > 0.05).

CONCLUSION

Vagal nerve may play an important role in the initiation of AF originating from pulmonary veins.

Authors+Show Affiliations

Liu P
Department of Clinical Electrophysiology, People's Hospital, Beijing University, Beijing 100044, China.
Guo JH
No affiliation info available
Zhang HC
No affiliation info available
Sun JL
No affiliation info available
Yi Z
No affiliation info available
Liu G
No affiliation info available

MeSH

AnimalsAnti-Arrhythmia AgentsAtrial FibrillationAtropineAutonomic DenervationDisease Models, AnimalDogsMalePulmonary VeinsVagus Nerve

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

16677524

Citation

Liu, Peng, et al. "[Vagal Effects On Inducibility of Atrial Fibrillation at Different Sites of Pulmonary Veins After Autonomic Denervation]." Zhonghua Yi Xue Za Zhi, vol. 86, no. 5, 2006, pp. 317-20.
Liu P, Guo JH, Zhang HC, et al. [Vagal effects on inducibility of atrial fibrillation at different sites of pulmonary veins after autonomic denervation]. Zhonghua Yi Xue Za Zhi. 2006;86(5):317-20.
Liu, P., Guo, J. H., Zhang, H. C., Sun, J. L., Yi, Z., & Liu, G. (2006). [Vagal effects on inducibility of atrial fibrillation at different sites of pulmonary veins after autonomic denervation]. Zhonghua Yi Xue Za Zhi, 86(5), 317-20.
Liu P, et al. [Vagal Effects On Inducibility of Atrial Fibrillation at Different Sites of Pulmonary Veins After Autonomic Denervation]. Zhonghua Yi Xue Za Zhi. 2006 Feb 7;86(5):317-20. PubMed PMID: 16677524.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Vagal effects on inducibility of atrial fibrillation at different sites of pulmonary veins after autonomic denervation]. AU - Liu,Peng, AU - Guo,Ji-hong, AU - Zhang,Hai-cheng, AU - Sun,Jian-ling, AU - Yi,Zhong, AU - Liu,Gang, PY - 2006/5/9/pubmed PY - 2008/3/4/medline PY - 2006/5/9/entrez SP - 317 EP - 20 JF - Zhonghua yi xue za zhi JO - Zhonghua Yi Xue Za Zhi VL - 86 IS - 5 N2 - OBJECTIVE: To investigate the vagal effects on the inducibility of atrial fibrillation (AF) at different sites of pulmonary vein after autonomic denervation. METHODS: The bilateral cervical vagal trunks of 10 male mongrel dogs were isolated and decentralized. The ansae subclaviae were exposed, ligated, and cut. Needle electrodes were inserted into the subcutaneous tissue of the 4 extremities to record the myocardiogram. Right ventricle electrode was introduced via femoral vein and an electrode with 4 poles was sutured with the right appendage (RAA), left appendage (LAA), left atrium (LA), left superior pulmonary vein (LSPV), right superior pulmonary vein (RSPV), left inferior pulmonary vein (LIPV), and right inferior pulmonary vein (RIPV) respectively. Local burst stimulation (S1S1 = 80 ms, impulse duration = 0.5 ms) was performed on these sites to record the baseline AF inducibility. When sinus cardiac arrest for 2 s or complete atrio-ventricular block occurred programmed bilateral vagal nerves stimulation (VNS) was performed with the frequency of 12.5 Hz, impulse duration of 0.5 ms, and voltage of 5-8 V. Atropine 0.04 mg/kg was dripped intravenously. The changes of AV inducibility were observed. RESULTS: In the baseline state, S1S1 programmed stimulation on all the sites evoked single or multiple atrial premature beats and short runs of atrial tachycardia, only a few sites induced AF. However, S1S1 programmed stimulation combined with VNS significantly increased the frequencies of induced AV at the sites of 4 PVs (P < 0.05, P < 0.01). When atropine was dripped the AV induction rates at all sites did not changed significantly (all P > 0.05). CONCLUSION: Vagal nerve may play an important role in the initiation of AF originating from pulmonary veins. SN - 0376-2491 UR - https://www.unboundmedicine.com/medline/citation/16677524/[Vagal_effects_on_inducibility_of_atrial_fibrillation_at_different_sites_of_pulmonary_veins_after_autonomic_denervation]_ DB - PRIME DP - Unbound Medicine ER -