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Use of letrozole versus clomiphene citrate combined with gonadotropins in intrauterine insemination cycles: a pilot study.
Fertil Steril. 2006 Jun; 85(6):1774-7.FS

Abstract

OBJECTIVE

To compare the clinical outcomes between letrozole and clomiphene citrate (CC) in gonadotropin-combined intrauterine insemination (IUI) cycles.

DESIGN

Prospective pilot study.

SETTING

One university hospital and two private infertility clinics.

PATIENT(S)

Ninety-three infertile couples eligible for superovulation and IUI.

INTERVENTION(S)

A letrozole dose of 2.5 mg/day (n = 66) or a CC dose of 100 mg/day (n = 27) was given on day 3-7 of the menstrual cycle, combined with human menopausal gonadotropin (hMG) at a dose 150 IU every other day starting on day 5.

MAIN OUTCOME MEASURE(S)

The number of mature follicles, serum estradiol (E2) and progesterone (P) levels, endometrial thicknesses on the day of human chorionic gonadotropin (hCG), and clinical pregnancy rates.

RESULT(S)

The patients' clinical characteristics were comparable between the two groups. The number of mature follicles (3.2 +/- 1.7 vs. 5.6 +/- 2.4) and serum E2 levels on the day of hCG (231.0 +/- 179.8 vs. 1,371.7 +/- 750.5 pg/mL) were significantly lower in the letrozole group. No significant differences were found in endometrial thickness measured on the day of hCG or clinical pregnancy rates (18.2% vs. 25.9%). The rate of patients with serum P levels > 1.0 ng/mL on the day of hCG was significantly lower in the letrozole group (4.5% vs. 25.9%).

CONCLUSION(S)

Letrozole produced a comparable pregnancy rate vs. CC in gonadotropin-combined IUI cycles. Our results should be confirmed in larger populations with proper randomization.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

16677640

Citation

Jee, Byung Chul, et al. "Use of Letrozole Versus Clomiphene Citrate Combined With Gonadotropins in Intrauterine Insemination Cycles: a Pilot Study." Fertility and Sterility, vol. 85, no. 6, 2006, pp. 1774-7.
Jee BC, Ku SY, Suh CS, et al. Use of letrozole versus clomiphene citrate combined with gonadotropins in intrauterine insemination cycles: a pilot study. Fertil Steril. 2006;85(6):1774-7.
Jee, B. C., Ku, S. Y., Suh, C. S., Kim, K. C., Lee, W. D., & Kim, S. H. (2006). Use of letrozole versus clomiphene citrate combined with gonadotropins in intrauterine insemination cycles: a pilot study. Fertility and Sterility, 85(6), 1774-7.
Jee BC, et al. Use of Letrozole Versus Clomiphene Citrate Combined With Gonadotropins in Intrauterine Insemination Cycles: a Pilot Study. Fertil Steril. 2006;85(6):1774-7. PubMed PMID: 16677640.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Use of letrozole versus clomiphene citrate combined with gonadotropins in intrauterine insemination cycles: a pilot study. AU - Jee,Byung Chul, AU - Ku,Seung Yup, AU - Suh,Chang Suk, AU - Kim,Ki Chul, AU - Lee,Won Don, AU - Kim,Seok Hyun, Y1 - 2006/05/04/ PY - 2005/11/20/received PY - 2006/02/10/revised PY - 2006/02/10/accepted PY - 2006/5/9/pubmed PY - 2006/6/28/medline PY - 2006/5/9/entrez SP - 1774 EP - 7 JF - Fertility and sterility JO - Fertil. Steril. VL - 85 IS - 6 N2 - OBJECTIVE: To compare the clinical outcomes between letrozole and clomiphene citrate (CC) in gonadotropin-combined intrauterine insemination (IUI) cycles. DESIGN: Prospective pilot study. SETTING: One university hospital and two private infertility clinics. PATIENT(S): Ninety-three infertile couples eligible for superovulation and IUI. INTERVENTION(S): A letrozole dose of 2.5 mg/day (n = 66) or a CC dose of 100 mg/day (n = 27) was given on day 3-7 of the menstrual cycle, combined with human menopausal gonadotropin (hMG) at a dose 150 IU every other day starting on day 5. MAIN OUTCOME MEASURE(S): The number of mature follicles, serum estradiol (E2) and progesterone (P) levels, endometrial thicknesses on the day of human chorionic gonadotropin (hCG), and clinical pregnancy rates. RESULT(S): The patients' clinical characteristics were comparable between the two groups. The number of mature follicles (3.2 +/- 1.7 vs. 5.6 +/- 2.4) and serum E2 levels on the day of hCG (231.0 +/- 179.8 vs. 1,371.7 +/- 750.5 pg/mL) were significantly lower in the letrozole group. No significant differences were found in endometrial thickness measured on the day of hCG or clinical pregnancy rates (18.2% vs. 25.9%). The rate of patients with serum P levels > 1.0 ng/mL on the day of hCG was significantly lower in the letrozole group (4.5% vs. 25.9%). CONCLUSION(S): Letrozole produced a comparable pregnancy rate vs. CC in gonadotropin-combined IUI cycles. Our results should be confirmed in larger populations with proper randomization. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/16677640/Use_of_letrozole_versus_clomiphene_citrate_combined_with_gonadotropins_in_intrauterine_insemination_cycles:_a_pilot_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(06)00513-9 DB - PRIME DP - Unbound Medicine ER -