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Smoking and atherosclerotic cardiovascular disease in women with lower levels of serum cholesterol.
Atherosclerosis 2007; 190(2):306-12A

Abstract

This cohort study of Koreans examines the relationship between smoking on atherosclerotic cardiovascular disease (ASCVD) and whether serum levels of total cholesterol modify the impact of smoking on ASCVD. A 10-year prospective cohort study was carried out on 234,399 Korean women, ranging 40-69 years of age who received health insurance from the National Health Insurance Corporation and had a medical evaluation in 1993. The main outcome measures were hospital admissions and deaths from ischemic heart disease (IHD), cerebrovascular disease (CVD), and total ASCVD. At baseline, 13,696 (5.8%) were current smokers and 105,755 (45.1%) had a total cholesterol <200mg/dl. Between 1994 and 2003, 4534 IHD (176/100,000 person year), 7961 CVD (310/100,000 person year), and 2418 other ASCVD events (94/100,000 person year) occurred. In multivariate Cox proportional hazard models controlling for age, hypertension, hypercholesterolemia, diabetes and alcohol drinking, current smoking increased the risk of IHD [hazard ratio (HR)=1.7 (95% CI: 1.5-1.9)], CVD [HR=1.6 (95% CI: 1.5-1.6)], and total ASCVD events [HR=1.6 (95% CI: 1.5-1.7)]. Throughout the range of serum cholesterol levels, current smoking significantly increased the risk of myocardial infarction and CVD, but not angina pectoris. There was no evidence of an interaction between smoking and serum cholesterol (p for interaction=0.469, 0.612, and 0.905 for IHD, CVD, and total ASCVD, respectively). This study demonstrated that smoking was a major independent risk factor for IHD, CVD and ASCVD in Korean women. A low cholesterol level confers no protective benefit against smoking-related ASCVD.

Authors+Show Affiliations

Department of Epidemiology, Graduate School of Public Health, Yonsei University, Seoul, Republic of Korea. jsunha@yumc.yonsei.ac.krNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16677653

Citation

Jee, Sun Ha, et al. "Smoking and Atherosclerotic Cardiovascular Disease in Women With Lower Levels of Serum Cholesterol." Atherosclerosis, vol. 190, no. 2, 2007, pp. 306-12.
Jee SH, Park J, Jo I, et al. Smoking and atherosclerotic cardiovascular disease in women with lower levels of serum cholesterol. Atherosclerosis. 2007;190(2):306-12.
Jee, S. H., Park, J., Jo, I., Lee, J., Yun, S., Yun, J. E., & Jang, Y. (2007). Smoking and atherosclerotic cardiovascular disease in women with lower levels of serum cholesterol. Atherosclerosis, 190(2), pp. 306-12.
Jee SH, et al. Smoking and Atherosclerotic Cardiovascular Disease in Women With Lower Levels of Serum Cholesterol. Atherosclerosis. 2007;190(2):306-12. PubMed PMID: 16677653.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Smoking and atherosclerotic cardiovascular disease in women with lower levels of serum cholesterol. AU - Jee,Sun Ha, AU - Park,Jungyong, AU - Jo,Inho, AU - Lee,Jakyoung, AU - Yun,Soojin, AU - Yun,Ji-Eun, AU - Jang,Yangsu, Y1 - 2006/05/04/ PY - 2005/10/23/received PY - 2006/02/08/revised PY - 2006/03/14/accepted PY - 2006/5/9/pubmed PY - 2007/8/7/medline PY - 2006/5/9/entrez SP - 306 EP - 12 JF - Atherosclerosis JO - Atherosclerosis VL - 190 IS - 2 N2 - This cohort study of Koreans examines the relationship between smoking on atherosclerotic cardiovascular disease (ASCVD) and whether serum levels of total cholesterol modify the impact of smoking on ASCVD. A 10-year prospective cohort study was carried out on 234,399 Korean women, ranging 40-69 years of age who received health insurance from the National Health Insurance Corporation and had a medical evaluation in 1993. The main outcome measures were hospital admissions and deaths from ischemic heart disease (IHD), cerebrovascular disease (CVD), and total ASCVD. At baseline, 13,696 (5.8%) were current smokers and 105,755 (45.1%) had a total cholesterol <200mg/dl. Between 1994 and 2003, 4534 IHD (176/100,000 person year), 7961 CVD (310/100,000 person year), and 2418 other ASCVD events (94/100,000 person year) occurred. In multivariate Cox proportional hazard models controlling for age, hypertension, hypercholesterolemia, diabetes and alcohol drinking, current smoking increased the risk of IHD [hazard ratio (HR)=1.7 (95% CI: 1.5-1.9)], CVD [HR=1.6 (95% CI: 1.5-1.6)], and total ASCVD events [HR=1.6 (95% CI: 1.5-1.7)]. Throughout the range of serum cholesterol levels, current smoking significantly increased the risk of myocardial infarction and CVD, but not angina pectoris. There was no evidence of an interaction between smoking and serum cholesterol (p for interaction=0.469, 0.612, and 0.905 for IHD, CVD, and total ASCVD, respectively). This study demonstrated that smoking was a major independent risk factor for IHD, CVD and ASCVD in Korean women. A low cholesterol level confers no protective benefit against smoking-related ASCVD. SN - 0021-9150 UR - https://www.unboundmedicine.com/medline/citation/16677653/Smoking_and_atherosclerotic_cardiovascular_disease_in_women_with_lower_levels_of_serum_cholesterol_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9150(06)00166-3 DB - PRIME DP - Unbound Medicine ER -