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Effects of phencyclidine on spatial learning and memory: nitric oxide-dependent mechanisms.
Behav Brain Res. 2006 Jul 15; 171(1):147-53.BB

Abstract

Cognitive deficits of schizophrenia constitute a disabling part of the disease predicting treatment success as well as functional outcome. Phencyclidine (PCP), a non-competitive NMDA receptor antagonist was used to model schizophrenic cognitive dysfunctions of learning and memory using the Morris water maze paradigm for reference memory. In experiment 1 male Sprauge-Dawley rats were acutely administered PCP (0.5, 1.0 and 2.0 mg/kg s.c.) before the first swim session on each of the four acquisition days. Probe test for reference memory was performed 2 days after the last acquisition day; the first probe without drug treatment to assess reference memory and a second probe with prior drug treatment to control for state dependency effects of PCP. In experiment 2 the effects of pre-treatment (10 min before PCP) with the nitric oxide synthase inhibitor, L-NAME (10 mg/kg s.c.), on the PCP (2 mg/kg)-induced spatial memory deficit was evaluated in the Morris water maze paradigm for reference memory. The results showed that PCP in a dose of 2 mg/kg disrupts spatial learning as estimated by prolonged search time to find platform during acquisition as well as the reference memory test as measured by less time spent in target quadrant during probe trial. No state dependency effects of PCP were found. Pre-treatment with L-NAME completely reversed the PCP-induced disruption of acquisition learning. The reference memory disruption was, however, not completely restored as measured by probe trial.

Authors+Show Affiliations

Department of Pharmacology, The Sahlgrenska Academy at Göteborg University, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16677724

Citation

Wass, Caroline, et al. "Effects of Phencyclidine On Spatial Learning and Memory: Nitric Oxide-dependent Mechanisms." Behavioural Brain Research, vol. 171, no. 1, 2006, pp. 147-53.
Wass C, Archer T, Pålsson E, et al. Effects of phencyclidine on spatial learning and memory: nitric oxide-dependent mechanisms. Behav Brain Res. 2006;171(1):147-53.
Wass, C., Archer, T., Pålsson, E., Fejgin, K., Klamer, D., Engel, J. A., & Svensson, L. (2006). Effects of phencyclidine on spatial learning and memory: nitric oxide-dependent mechanisms. Behavioural Brain Research, 171(1), 147-53.
Wass C, et al. Effects of Phencyclidine On Spatial Learning and Memory: Nitric Oxide-dependent Mechanisms. Behav Brain Res. 2006 Jul 15;171(1):147-53. PubMed PMID: 16677724.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of phencyclidine on spatial learning and memory: nitric oxide-dependent mechanisms. AU - Wass,Caroline, AU - Archer,Trevor, AU - Pålsson,Erik, AU - Fejgin,Kim, AU - Klamer,Daniel, AU - Engel,Jörgen A, AU - Svensson,Lennart, Y1 - 2006/05/04/ PY - 2005/12/30/received PY - 2006/03/20/revised PY - 2006/03/27/accepted PY - 2006/5/9/pubmed PY - 2006/8/4/medline PY - 2006/5/9/entrez SP - 147 EP - 53 JF - Behavioural brain research JO - Behav Brain Res VL - 171 IS - 1 N2 - Cognitive deficits of schizophrenia constitute a disabling part of the disease predicting treatment success as well as functional outcome. Phencyclidine (PCP), a non-competitive NMDA receptor antagonist was used to model schizophrenic cognitive dysfunctions of learning and memory using the Morris water maze paradigm for reference memory. In experiment 1 male Sprauge-Dawley rats were acutely administered PCP (0.5, 1.0 and 2.0 mg/kg s.c.) before the first swim session on each of the four acquisition days. Probe test for reference memory was performed 2 days after the last acquisition day; the first probe without drug treatment to assess reference memory and a second probe with prior drug treatment to control for state dependency effects of PCP. In experiment 2 the effects of pre-treatment (10 min before PCP) with the nitric oxide synthase inhibitor, L-NAME (10 mg/kg s.c.), on the PCP (2 mg/kg)-induced spatial memory deficit was evaluated in the Morris water maze paradigm for reference memory. The results showed that PCP in a dose of 2 mg/kg disrupts spatial learning as estimated by prolonged search time to find platform during acquisition as well as the reference memory test as measured by less time spent in target quadrant during probe trial. No state dependency effects of PCP were found. Pre-treatment with L-NAME completely reversed the PCP-induced disruption of acquisition learning. The reference memory disruption was, however, not completely restored as measured by probe trial. SN - 0166-4328 UR - https://www.unboundmedicine.com/medline/citation/16677724/Effects_of_phencyclidine_on_spatial_learning_and_memory:_nitric_oxide_dependent_mechanisms_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(06)00194-X DB - PRIME DP - Unbound Medicine ER -