Tags

Type your tag names separated by a space and hit enter

Reduction of dopaminergic degeneration and oxidative stress by inhibition of angiotensin converting enzyme in a MPTP model of parkinsonism.
Neuropharmacology. 2006 Jul; 51(1):112-20.N

Abstract

There is growing evidence indicating that oxidative stress is a key contributor to the pathogenesis and progression of Parkinson's disease. The brain, and particularly the basal ganglia, possesses a local rennin-angiotensin system. Angiotensin activates NAD(P)H-dependent oxidases, which are a major intracellular source of superoxide, and angiotensin converting enzyme inhibitors (ACEIs) have shown antioxidant properties. We treated mice with MPTP and the ACEI captopril to study the possible neuroprotective and antioxidant effects of the latter on the dopaminergic system. Pre-treatment with captopril induced a significant reduction in the MPTP-induced loss of dopaminergic neurons in the substantia nigra and a significant reduction in the loss of dopaminergic terminals in the striatum. Furthermore, captopril reduced the MPTP-induced increase in the levels of major oxidative stress indicators (i.e. lipid peroxidation and protein oxidation) in the ventral midbrain and the striatum. Captopril did not reduce striatal MPP(+) levels, MAO-B activity or dopamine transporter activity, which may reduce MPTP neurotoxicity. Our results suggest that angiotensin-converting enzyme inhibitors may be useful for treatment of Parkinson's disease, and that further investigation should focus on the neuroprotective capacity of these compounds.

Authors+Show Affiliations

Laboratory of Neuroanatomy and Experimental Neurology, Department of Morphological Sciences, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16678218

Citation

Muñoz, Ana, et al. "Reduction of Dopaminergic Degeneration and Oxidative Stress By Inhibition of Angiotensin Converting Enzyme in a MPTP Model of Parkinsonism." Neuropharmacology, vol. 51, no. 1, 2006, pp. 112-20.
Muñoz A, Rey P, Guerra MJ, et al. Reduction of dopaminergic degeneration and oxidative stress by inhibition of angiotensin converting enzyme in a MPTP model of parkinsonism. Neuropharmacology. 2006;51(1):112-20.
Muñoz, A., Rey, P., Guerra, M. J., Mendez-Alvarez, E., Soto-Otero, R., & Labandeira-Garcia, J. L. (2006). Reduction of dopaminergic degeneration and oxidative stress by inhibition of angiotensin converting enzyme in a MPTP model of parkinsonism. Neuropharmacology, 51(1), 112-20.
Muñoz A, et al. Reduction of Dopaminergic Degeneration and Oxidative Stress By Inhibition of Angiotensin Converting Enzyme in a MPTP Model of Parkinsonism. Neuropharmacology. 2006;51(1):112-20. PubMed PMID: 16678218.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reduction of dopaminergic degeneration and oxidative stress by inhibition of angiotensin converting enzyme in a MPTP model of parkinsonism. AU - Muñoz,Ana, AU - Rey,Pablo, AU - Guerra,Maria J, AU - Mendez-Alvarez,Estefania, AU - Soto-Otero,Ramon, AU - Labandeira-Garcia,Jose L, Y1 - 2006/05/05/ PY - 2005/10/31/received PY - 2006/02/24/revised PY - 2006/03/07/accepted PY - 2006/5/9/pubmed PY - 2006/9/12/medline PY - 2006/5/9/entrez SP - 112 EP - 20 JF - Neuropharmacology JO - Neuropharmacology VL - 51 IS - 1 N2 - There is growing evidence indicating that oxidative stress is a key contributor to the pathogenesis and progression of Parkinson's disease. The brain, and particularly the basal ganglia, possesses a local rennin-angiotensin system. Angiotensin activates NAD(P)H-dependent oxidases, which are a major intracellular source of superoxide, and angiotensin converting enzyme inhibitors (ACEIs) have shown antioxidant properties. We treated mice with MPTP and the ACEI captopril to study the possible neuroprotective and antioxidant effects of the latter on the dopaminergic system. Pre-treatment with captopril induced a significant reduction in the MPTP-induced loss of dopaminergic neurons in the substantia nigra and a significant reduction in the loss of dopaminergic terminals in the striatum. Furthermore, captopril reduced the MPTP-induced increase in the levels of major oxidative stress indicators (i.e. lipid peroxidation and protein oxidation) in the ventral midbrain and the striatum. Captopril did not reduce striatal MPP(+) levels, MAO-B activity or dopamine transporter activity, which may reduce MPTP neurotoxicity. Our results suggest that angiotensin-converting enzyme inhibitors may be useful for treatment of Parkinson's disease, and that further investigation should focus on the neuroprotective capacity of these compounds. SN - 0028-3908 UR - https://www.unboundmedicine.com/medline/citation/16678218/Reduction_of_dopaminergic_degeneration_and_oxidative_stress_by_inhibition_of_angiotensin_converting_enzyme_in_a_MPTP_model_of_parkinsonism_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0028-3908(06)00053-0 DB - PRIME DP - Unbound Medicine ER -