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In patients with Helicobacter pylori gastritis and functional dyspepsia, a biopsy from the incisura angularis provides useful diagnostic information.
Pathol Res Pract. 2006; 202(6):405-13.PR

Abstract

The aim of this study was to assess whether the taking of an additional biopsy from the incisura angularis increases the chance of detecting maximal degrees of atrophy and intestinal metaplasia (IM) in patients with Helicobacter pylori gastritis and functional dyspepsia. At entry into a randomised trial, biopsies were taken from 328 patients (mean age 48 years), two from both the gastric antrum and corpus, and one from the incisura angularis, and comparative grading of gastritis variables was carried out. Biopsy material from the gastric antrum, corpus, and the incisura angularis revealed no notable differences in atrophy or an incidence of IM and mucosa-associated lymphatic tissue. However, when the incisura biopsies were classified histologically, 58% contained antral mucosa (AM), 18% corpus mucosa (CM), and 24% intermediate zone mucosa. AM at the incisura was associated with considerably more severe gastritis in both the incisura and antrum (14% atrophy, 20% IM) than in CM of incisura (2% atrophy, 6% IM). Corpus atrophy and IM were rare in the AM group and absent from the CM group. Incisura angularis biopsy in patients with H. pylori gastritis and functional dyspepsia does give additional information regarding the severity of gastritis expected in the corpus and antrum. Antral-type mucosa in the incisura angularis region seems to indicate an increased risk for the development of atrophy and/or IM.

Authors+Show Affiliations

Institute of Pathology, Klinikum Bayreuth, Germany. pathologie.klinikum-bayreuth@t-online.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

16678357

Citation

Stolte, Manfred, et al. "In Patients With Helicobacter Pylori Gastritis and Functional Dyspepsia, a Biopsy From the Incisura Angularis Provides Useful Diagnostic Information." Pathology, Research and Practice, vol. 202, no. 6, 2006, pp. 405-13.
Stolte M, Müller H, Talley NJ, et al. In patients with Helicobacter pylori gastritis and functional dyspepsia, a biopsy from the incisura angularis provides useful diagnostic information. Pathol Res Pract. 2006;202(6):405-13.
Stolte, M., Müller, H., Talley, N. J., O'morain, C., Bolling-Sternevald, E., Sundin, M., Eriksson, S., & Blum, A. (2006). In patients with Helicobacter pylori gastritis and functional dyspepsia, a biopsy from the incisura angularis provides useful diagnostic information. Pathology, Research and Practice, 202(6), 405-13.
Stolte M, et al. In Patients With Helicobacter Pylori Gastritis and Functional Dyspepsia, a Biopsy From the Incisura Angularis Provides Useful Diagnostic Information. Pathol Res Pract. 2006;202(6):405-13. PubMed PMID: 16678357.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In patients with Helicobacter pylori gastritis and functional dyspepsia, a biopsy from the incisura angularis provides useful diagnostic information. AU - Stolte,Manfred, AU - Müller,Heiko, AU - Talley,Nicholas J, AU - O'morain,Colm, AU - Bolling-Sternevald,Elisabeth, AU - Sundin,Marie, AU - Eriksson,Sven, AU - Blum,André, Y1 - 2006/05/05/ PY - 2005/11/09/received PY - 2006/01/27/accepted PY - 2006/5/9/pubmed PY - 2006/7/21/medline PY - 2006/5/9/entrez SP - 405 EP - 13 JF - Pathology, research and practice JO - Pathol Res Pract VL - 202 IS - 6 N2 - The aim of this study was to assess whether the taking of an additional biopsy from the incisura angularis increases the chance of detecting maximal degrees of atrophy and intestinal metaplasia (IM) in patients with Helicobacter pylori gastritis and functional dyspepsia. At entry into a randomised trial, biopsies were taken from 328 patients (mean age 48 years), two from both the gastric antrum and corpus, and one from the incisura angularis, and comparative grading of gastritis variables was carried out. Biopsy material from the gastric antrum, corpus, and the incisura angularis revealed no notable differences in atrophy or an incidence of IM and mucosa-associated lymphatic tissue. However, when the incisura biopsies were classified histologically, 58% contained antral mucosa (AM), 18% corpus mucosa (CM), and 24% intermediate zone mucosa. AM at the incisura was associated with considerably more severe gastritis in both the incisura and antrum (14% atrophy, 20% IM) than in CM of incisura (2% atrophy, 6% IM). Corpus atrophy and IM were rare in the AM group and absent from the CM group. Incisura angularis biopsy in patients with H. pylori gastritis and functional dyspepsia does give additional information regarding the severity of gastritis expected in the corpus and antrum. Antral-type mucosa in the incisura angularis region seems to indicate an increased risk for the development of atrophy and/or IM. SN - 0344-0338 UR - https://www.unboundmedicine.com/medline/citation/16678357/In_patients_with_Helicobacter_pylori_gastritis_and_functional_dyspepsia_a_biopsy_from_the_incisura_angularis_provides_useful_diagnostic_information_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0344-0338(06)00050-1 DB - PRIME DP - Unbound Medicine ER -