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Insulin resistance and impaired glucose tolerance in obese children and adolescents from Southern Italy.
Nutr Metab Cardiovasc Dis. 2006 May; 16(4):279-84.NM

Abstract

BACKGROUND AND AIM

Obesity in children may lead to insulin resistance and impaired glucose regulation over time. The aim of this study was to investigate the insulin resistance status and the frequency of impaired glucose regulation in obese children and adolescents from the Campania region (Southern Italy), where the prevalence of obesity is among the highest in Europe.

METHODS AND RESULTS

We studied 100 (62 male) Italian obese children and adolescents (mean age 10.1+/-2.7 years) and 50 (27 male) normal weight healthy subjects (mean age 10.2+/-2.7 years). Anthropometric measures and biochemical tests were performed in all subjects. In obese patients an oral glucose tolerance test was also performed. The estimate of insulin resistance was calculated by a homeostasis model assessment (HOMA) index. A cut-off HOMA level of >2.5 in children and >4.0 in adolescents was used to identify an insulin-resistance status. Insulin resistance was found in 40.8% of obese children and 41.2% of obese adolescents, whereas it was found in 3.0% of normal children and none of the 17 normal adolescents (p<0.0001 and p<0.002, respectively). None of the subjects had impaired fasting glucose or diabetes, while 4 obese patients had impaired glucose tolerance (4%).

CONCLUSIONS

Impaired glucose tolerance is still rare whereas insulin-resistance is already detectable in more than 40% of obese children and adolescents in Southern Italy. Our observations confirm that metabolic risk factors can be found at a very early age and strengthen the case for implementing programmes for prevention and treatment of childhood obesity.

Authors+Show Affiliations

School of Movement Sciences (DiSISTe), Parthenope University, via Acton 38, 80133 Naples, Italy. giuliana.valerio@uniparthenope.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16679220

Citation

Valerio, G, et al. "Insulin Resistance and Impaired Glucose Tolerance in Obese Children and Adolescents From Southern Italy." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 16, no. 4, 2006, pp. 279-84.
Valerio G, Licenziati MR, Iannuzzi A, et al. Insulin resistance and impaired glucose tolerance in obese children and adolescents from Southern Italy. Nutr Metab Cardiovasc Dis. 2006;16(4):279-84.
Valerio, G., Licenziati, M. R., Iannuzzi, A., Franzese, A., Siani, P., Riccardi, G., & Rubba, P. (2006). Insulin resistance and impaired glucose tolerance in obese children and adolescents from Southern Italy. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 16(4), 279-84.
Valerio G, et al. Insulin Resistance and Impaired Glucose Tolerance in Obese Children and Adolescents From Southern Italy. Nutr Metab Cardiovasc Dis. 2006;16(4):279-84. PubMed PMID: 16679220.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Insulin resistance and impaired glucose tolerance in obese children and adolescents from Southern Italy. AU - Valerio,G, AU - Licenziati,M R, AU - Iannuzzi,A, AU - Franzese,A, AU - Siani,P, AU - Riccardi,G, AU - Rubba,P, Y1 - 2006/03/20/ PY - 2005/09/07/received PY - 2005/11/22/revised PY - 2005/12/06/accepted PY - 2006/5/9/pubmed PY - 2006/8/29/medline PY - 2006/5/9/entrez SP - 279 EP - 84 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 16 IS - 4 N2 - BACKGROUND AND AIM: Obesity in children may lead to insulin resistance and impaired glucose regulation over time. The aim of this study was to investigate the insulin resistance status and the frequency of impaired glucose regulation in obese children and adolescents from the Campania region (Southern Italy), where the prevalence of obesity is among the highest in Europe. METHODS AND RESULTS: We studied 100 (62 male) Italian obese children and adolescents (mean age 10.1+/-2.7 years) and 50 (27 male) normal weight healthy subjects (mean age 10.2+/-2.7 years). Anthropometric measures and biochemical tests were performed in all subjects. In obese patients an oral glucose tolerance test was also performed. The estimate of insulin resistance was calculated by a homeostasis model assessment (HOMA) index. A cut-off HOMA level of >2.5 in children and >4.0 in adolescents was used to identify an insulin-resistance status. Insulin resistance was found in 40.8% of obese children and 41.2% of obese adolescents, whereas it was found in 3.0% of normal children and none of the 17 normal adolescents (p<0.0001 and p<0.002, respectively). None of the subjects had impaired fasting glucose or diabetes, while 4 obese patients had impaired glucose tolerance (4%). CONCLUSIONS: Impaired glucose tolerance is still rare whereas insulin-resistance is already detectable in more than 40% of obese children and adolescents in Southern Italy. Our observations confirm that metabolic risk factors can be found at a very early age and strengthen the case for implementing programmes for prevention and treatment of childhood obesity. SN - 0939-4753 UR - https://www.unboundmedicine.com/medline/citation/16679220/Insulin_resistance_and_impaired_glucose_tolerance_in_obese_children_and_adolescents_from_Southern_Italy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(06)00011-1 DB - PRIME DP - Unbound Medicine ER -