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[Inhibitors for protein tyrosine kinases, erbstatin, genistein and herbimycin A, induce differentiation of human neural tumor cell lines].
Nihon Geka Hokan. 1991 Mar 01; 60(2):113-21.NG

Abstract

Recent reports suggest that protein phosphorylation is involved in neural differentiation. We have found that specific inhibitors of protein phosphorylation at tyrosine residues, Erbstatin, Genistein, Herbimycin A, effectively induce neural differentiation in a human neuroblastoma cell line SK-N-DZ and a human medulloblastoma cell line Med-3, as indicated by the marked increase in the number of neurites/cell and in the expression of neurofilaments (160 k) detected by immunohistochemical studies. Possible involvement of protein phosphorylation at tyrosine residues in the differentiation of neural tumor cells was stressed.

Authors+Show Affiliations

Department of Neurosurgery, Kyoto University Medical School, Japan.

Pub Type(s)

English Abstract
Journal Article

Language

jpn

PubMed ID

1668058

Citation

Matsumoto, M. "[Inhibitors for Protein Tyrosine Kinases, Erbstatin, Genistein and Herbimycin A, Induce Differentiation of Human Neural Tumor Cell Lines]." Nihon Geka Hokan. Archiv Fur Japanische Chirurgie, vol. 60, no. 2, 1991, pp. 113-21.
Matsumoto M. [Inhibitors for protein tyrosine kinases, erbstatin, genistein and herbimycin A, induce differentiation of human neural tumor cell lines]. Nihon Geka Hokan. 1991;60(2):113-21.
Matsumoto, M. (1991). [Inhibitors for protein tyrosine kinases, erbstatin, genistein and herbimycin A, induce differentiation of human neural tumor cell lines]. Nihon Geka Hokan. Archiv Fur Japanische Chirurgie, 60(2), 113-21.
Matsumoto M. [Inhibitors for Protein Tyrosine Kinases, Erbstatin, Genistein and Herbimycin A, Induce Differentiation of Human Neural Tumor Cell Lines]. Nihon Geka Hokan. 1991 Mar 1;60(2):113-21. PubMed PMID: 1668058.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Inhibitors for protein tyrosine kinases, erbstatin, genistein and herbimycin A, induce differentiation of human neural tumor cell lines]. A1 - Matsumoto,M, PY - 1991/3/1/pubmed PY - 1991/3/1/medline PY - 1991/3/1/entrez SP - 113 EP - 21 JF - Nihon geka hokan. Archiv fur japanische Chirurgie JO - Nihon Geka Hokan VL - 60 IS - 2 N2 - Recent reports suggest that protein phosphorylation is involved in neural differentiation. We have found that specific inhibitors of protein phosphorylation at tyrosine residues, Erbstatin, Genistein, Herbimycin A, effectively induce neural differentiation in a human neuroblastoma cell line SK-N-DZ and a human medulloblastoma cell line Med-3, as indicated by the marked increase in the number of neurites/cell and in the expression of neurofilaments (160 k) detected by immunohistochemical studies. Possible involvement of protein phosphorylation at tyrosine residues in the differentiation of neural tumor cells was stressed. SN - 0003-9152 UR - https://www.unboundmedicine.com/medline/citation/1668058/[Inhibitors_for_protein_tyrosine_kinases_erbstatin_genistein_and_herbimycin_A_induce_differentiation_of_human_neural_tumor_cell_lines]_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:1668058 DB - PRIME DP - Unbound Medicine ER -