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Sildenafil citrate improves self-esteem, confidence, and relationships in men with erectile dysfunction: Results from an international, multi-center, double-blind, placebo-controlled trial.
J Sex Med. 2006 May; 3(3):521-9.JS

Abstract

INTRODUCTION

Erectile dysfunction (ED) can significantly impact a man's relationships and well-being.

AIM

We assessed changes in self-esteem, confidence, sexual relationship satisfaction, and overall relationship satisfaction in men with ED using the validated Self-Esteem And Relationship questionnaire (SEAR).

METHODS

This was a 12-week, double-blind, placebo-controlled, flexible-dose (25, 50, 100 mg, as needed) international study of sildenafil in men > or =18 years of age in Mexico, Brazil, Australia, and Japan.

MAIN OUTCOME MEASURES

The primary study outcome was change in self-esteem from baseline to the end of treatment. Secondary study measures were changes in other SEAR components, International Index of Erectile Function (IIEF) domains, percentage of intercourse attempts that were successful, and the response to a global efficacy question at the end of treatment.

RESULTS

Patients were well balanced for age and duration of ED (placebo = 149 and sildenafil = 151). Compared with placebo, sildenafil significantly improved self-esteem, confidence, sexual relationship satisfaction, and overall relationship satisfaction (P < 0.0001). The psychosocial measures of well-being assessed with the SEAR were positively correlated (range 0.60-0.86, P < 0.0001) with erectile function, the frequency of achieving erections that allowed satisfactory sexual intercourse, the percentage of successful sexual intercourse attempts, and global treatment efficacy.

CONCLUSIONS

Significant improvements in self-esteem, confidence, sexual relationship satisfaction, and overall relationship satisfaction after treatment of ED with sildenafil were consistent among countries. These data suggest a substantial cross-cultural improvement in well-being after successful treatment of ED with sildenafil.

Authors+Show Affiliations

Case Western Reserve University Medical School, West Palm Beach, FL33401, USA. sxa6@po.cwru.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

16681478

Citation

Althof, Stanley E., et al. "Sildenafil Citrate Improves Self-esteem, Confidence, and Relationships in Men With Erectile Dysfunction: Results From an International, Multi-center, Double-blind, Placebo-controlled Trial." The Journal of Sexual Medicine, vol. 3, no. 3, 2006, pp. 521-9.
Althof SE, O'leary MP, Cappelleri JC, et al. Sildenafil citrate improves self-esteem, confidence, and relationships in men with erectile dysfunction: Results from an international, multi-center, double-blind, placebo-controlled trial. J Sex Med. 2006;3(3):521-9.
Althof, S. E., O'leary, M. P., Cappelleri, J. C., Hvidsten, K., Stecher, V. J., Glina, S., King, R., & Siegel, R. L. (2006). Sildenafil citrate improves self-esteem, confidence, and relationships in men with erectile dysfunction: Results from an international, multi-center, double-blind, placebo-controlled trial. The Journal of Sexual Medicine, 3(3), 521-9.
Althof SE, et al. Sildenafil Citrate Improves Self-esteem, Confidence, and Relationships in Men With Erectile Dysfunction: Results From an International, Multi-center, Double-blind, Placebo-controlled Trial. J Sex Med. 2006;3(3):521-9. PubMed PMID: 16681478.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sildenafil citrate improves self-esteem, confidence, and relationships in men with erectile dysfunction: Results from an international, multi-center, double-blind, placebo-controlled trial. AU - Althof,Stanley E, AU - O'leary,Michael P, AU - Cappelleri,Joseph C, AU - Hvidsten,Kyle, AU - Stecher,Vera J, AU - Glina,Sidney, AU - King,Rosie, AU - Siegel,Richard L, AU - ,, PY - 2006/5/10/pubmed PY - 2006/8/3/medline PY - 2006/5/10/entrez SP - 521 EP - 9 JF - The journal of sexual medicine JO - J Sex Med VL - 3 IS - 3 N2 - INTRODUCTION: Erectile dysfunction (ED) can significantly impact a man's relationships and well-being. AIM: We assessed changes in self-esteem, confidence, sexual relationship satisfaction, and overall relationship satisfaction in men with ED using the validated Self-Esteem And Relationship questionnaire (SEAR). METHODS: This was a 12-week, double-blind, placebo-controlled, flexible-dose (25, 50, 100 mg, as needed) international study of sildenafil in men > or =18 years of age in Mexico, Brazil, Australia, and Japan. MAIN OUTCOME MEASURES: The primary study outcome was change in self-esteem from baseline to the end of treatment. Secondary study measures were changes in other SEAR components, International Index of Erectile Function (IIEF) domains, percentage of intercourse attempts that were successful, and the response to a global efficacy question at the end of treatment. RESULTS: Patients were well balanced for age and duration of ED (placebo = 149 and sildenafil = 151). Compared with placebo, sildenafil significantly improved self-esteem, confidence, sexual relationship satisfaction, and overall relationship satisfaction (P < 0.0001). The psychosocial measures of well-being assessed with the SEAR were positively correlated (range 0.60-0.86, P < 0.0001) with erectile function, the frequency of achieving erections that allowed satisfactory sexual intercourse, the percentage of successful sexual intercourse attempts, and global treatment efficacy. CONCLUSIONS: Significant improvements in self-esteem, confidence, sexual relationship satisfaction, and overall relationship satisfaction after treatment of ED with sildenafil were consistent among countries. These data suggest a substantial cross-cultural improvement in well-being after successful treatment of ED with sildenafil. SN - 1743-6095 UR - https://www.unboundmedicine.com/medline/citation/16681478/Sildenafil_citrate_improves_self_esteem_confidence_and_relationships_in_men_with_erectile_dysfunction:_Results_from_an_international_multi_center_double_blind_placebo_controlled_trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1743-6095(15)31343-6 DB - PRIME DP - Unbound Medicine ER -