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Is there a role for antileukotrienes in urticaria?
Clin Exp Dermatol. 2006 May; 31(3):327-34.CE

Abstract

In vitro and in vivo clinical and experimental data have suggested that leukotrienes play a key role in inflammatory reactions of the skin. Antileukotriene drugs, i.e. leukotriene receptor antagonists and synthesis inhibitors, are a new class of anti-inflammatory drugs that have shown clinical efficacy in the management of asthma. We searched the MedLine database and carried out a manual search on journals specializing in allergy and dermatology for the use of antileukotriene drugs in urticaria. Montelukast might be effective in chronic urticaria associated with aspirin or food additive hypersensitivity or with autoreactivity to intradermal serum injection when taken with an antihistamine but not in moderate chronic idiopathic urticaria. Evidence for the effectiveness of zafirlukast and the 5-lipoxygenase inhibitor, zileuton, in chronic urticaria is mainly anecdotal. In addition, there is anecdotal evidence of effectiveness of antileukotrienes in primary cold urticaria, delayed pressure urticaria and dermographism. No evidence exists for other physical urticarias, including cholinergic, solar and aquagenic urticarias, vibratory angio-oedema, and exercise-induced anaphylaxis.

Authors+Show Affiliations

Dipartimento di Medicina Clinica e Medicina Sperimentale, Università degli Studi di Verona, Italy. dilo601@unipa.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

16681569

Citation

Di Lorenzo, G, et al. "Is There a Role for Antileukotrienes in Urticaria?" Clinical and Experimental Dermatology, vol. 31, no. 3, 2006, pp. 327-34.
Di Lorenzo G, Pacor ML, Mansueto P, et al. Is there a role for antileukotrienes in urticaria? Clin Exp Dermatol. 2006;31(3):327-34.
Di Lorenzo, G., Pacor, M. L., Mansueto, P., Esposito-Pellitteri, M., Ditta, V., Lo Bianco, C., Leto-Barone, M. S., Di Fede, G., & Rini, G. B. (2006). Is there a role for antileukotrienes in urticaria? Clinical and Experimental Dermatology, 31(3), 327-34.
Di Lorenzo G, et al. Is There a Role for Antileukotrienes in Urticaria. Clin Exp Dermatol. 2006;31(3):327-34. PubMed PMID: 16681569.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is there a role for antileukotrienes in urticaria? AU - Di Lorenzo,G, AU - Pacor,M L, AU - Mansueto,P, AU - Esposito-Pellitteri,M, AU - Ditta,V, AU - Lo Bianco,C, AU - Leto-Barone,M S, AU - Di Fede,G, AU - Rini,G B, PY - 2006/5/10/pubmed PY - 2006/9/15/medline PY - 2006/5/10/entrez SP - 327 EP - 34 JF - Clinical and experimental dermatology JO - Clin Exp Dermatol VL - 31 IS - 3 N2 - In vitro and in vivo clinical and experimental data have suggested that leukotrienes play a key role in inflammatory reactions of the skin. Antileukotriene drugs, i.e. leukotriene receptor antagonists and synthesis inhibitors, are a new class of anti-inflammatory drugs that have shown clinical efficacy in the management of asthma. We searched the MedLine database and carried out a manual search on journals specializing in allergy and dermatology for the use of antileukotriene drugs in urticaria. Montelukast might be effective in chronic urticaria associated with aspirin or food additive hypersensitivity or with autoreactivity to intradermal serum injection when taken with an antihistamine but not in moderate chronic idiopathic urticaria. Evidence for the effectiveness of zafirlukast and the 5-lipoxygenase inhibitor, zileuton, in chronic urticaria is mainly anecdotal. In addition, there is anecdotal evidence of effectiveness of antileukotrienes in primary cold urticaria, delayed pressure urticaria and dermographism. No evidence exists for other physical urticarias, including cholinergic, solar and aquagenic urticarias, vibratory angio-oedema, and exercise-induced anaphylaxis. SN - 0307-6938 UR - https://www.unboundmedicine.com/medline/citation/16681569/Is_there_a_role_for_antileukotrienes_in_urticaria L2 - https://doi.org/10.1111/j.1365-2230.2006.02127.x DB - PRIME DP - Unbound Medicine ER -