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Effect of scopolamine on the hippocampal theta rhythm during an eight-arm radial maze task in rats.
Eur J Pharmacol. 2006 Jun 06; 539(1-2):76-80.EJ

Abstract

The changes in the hippocampal theta rhythm during an impairment of reference and working memory of radial maze task induced by scopolamine administration were studied. Intraperitoneal injection of scopolamine at doses of 0.5 and 1.0 mg/kg caused a significant increase in the number of total, reference memory and working memory errors. On the other hand, scopolamine significantly increased the hippocampal theta power (5-12 Hz) at doses (0.5 and 1.0 mg/kg) that caused an impairment of reference and working memory. A significant increase in the peak frequency of the hippocampal theta rhythm was also observed with scopolamine, even at a dose of 0.2 mg/kg. At doses of 0.2, 0.5 and 1.0 mg/kg, scopolamine caused a decrease in the locomotor activity during the radial maze task. From these results, it may be concluded that an increase in amplitude of the hippocampal theta rhythm induced by scopolamine is closely associated with memory/learning function of the eight-arm radial maze.

Authors+Show Affiliations

Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8530, Japan.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16682021

Citation

Masuoka, Takayoshi, et al. "Effect of Scopolamine On the Hippocampal Theta Rhythm During an Eight-arm Radial Maze Task in Rats." European Journal of Pharmacology, vol. 539, no. 1-2, 2006, pp. 76-80.
Masuoka T, Fujii Y, Kamei C. Effect of scopolamine on the hippocampal theta rhythm during an eight-arm radial maze task in rats. Eur J Pharmacol. 2006;539(1-2):76-80.
Masuoka, T., Fujii, Y., & Kamei, C. (2006). Effect of scopolamine on the hippocampal theta rhythm during an eight-arm radial maze task in rats. European Journal of Pharmacology, 539(1-2), 76-80.
Masuoka T, Fujii Y, Kamei C. Effect of Scopolamine On the Hippocampal Theta Rhythm During an Eight-arm Radial Maze Task in Rats. Eur J Pharmacol. 2006 Jun 6;539(1-2):76-80. PubMed PMID: 16682021.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of scopolamine on the hippocampal theta rhythm during an eight-arm radial maze task in rats. AU - Masuoka,Takayoshi, AU - Fujii,Yoko, AU - Kamei,Chiaki, Y1 - 2006/03/27/ PY - 2005/12/21/received PY - 2006/03/15/revised PY - 2006/03/17/accepted PY - 2006/5/10/pubmed PY - 2006/8/15/medline PY - 2006/5/10/entrez SP - 76 EP - 80 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 539 IS - 1-2 N2 - The changes in the hippocampal theta rhythm during an impairment of reference and working memory of radial maze task induced by scopolamine administration were studied. Intraperitoneal injection of scopolamine at doses of 0.5 and 1.0 mg/kg caused a significant increase in the number of total, reference memory and working memory errors. On the other hand, scopolamine significantly increased the hippocampal theta power (5-12 Hz) at doses (0.5 and 1.0 mg/kg) that caused an impairment of reference and working memory. A significant increase in the peak frequency of the hippocampal theta rhythm was also observed with scopolamine, even at a dose of 0.2 mg/kg. At doses of 0.2, 0.5 and 1.0 mg/kg, scopolamine caused a decrease in the locomotor activity during the radial maze task. From these results, it may be concluded that an increase in amplitude of the hippocampal theta rhythm induced by scopolamine is closely associated with memory/learning function of the eight-arm radial maze. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/16682021/Effect_of_scopolamine_on_the_hippocampal_theta_rhythm_during_an_eight_arm_radial_maze_task_in_rats_ DB - PRIME DP - Unbound Medicine ER -
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